No time for Twitter these days, but here's my sidekick and me at the end of last year...sorting out revisions for a paper that has now been ACCEPTED! 🎉

Grateful to see our work featured in this insightful News & Views in @embojournal. An erudite and perceptive analysis on physiological mitophagy in the nervous system— crafted by the outstanding Vassiliki Nikoletopoulou @Lab_Vassiliki @unil. Read it here: https://t.co/uaUFmJU5Iz

Grateful to see our work featured in this insightful News & Views in @embojournal. An erudite and perceptive analysis on physiological mitophagy in the nervous system— crafted by the outstanding Vassiliki Nikoletopoulou @Lab_Vassiliki @unil. Read it here: https://t.co/uaUFmJU5Iz

Excited to share our latest study published in @embojournal!!! 🙌🎉 We conducted a longitudinal analysis of physiological #mitophagy in healthy brain #aging, providing a deeper look at #autophagy pathways across neural space + time 🧠🔬 https://t.co/qeVRjvoK8i #mitochondria

More to follow in due course. My first tweet in two years...will probably be that long again. E-mail me if something here interests you. If you made this far...thanks for reading! .🥂🔚

🤝We could not have done this without #teamwork and our talented colleagues, friends and collaborators: Helena Vihinen and @EJokitalo from the @HiLIFE_helsinki EM Unit, and Antti Hassinen (@FIMM_UH); Homa Ehsan and @fumi_suomi; help from the incredible Biomedicum Imaging Unit in

Here I would like to thank @embojournal for their consummate professionalism, as always. The editorial process (@DanielKlimmeck) and the peer reviewers made a meaningful contribution, and made our manuscript better as a result. 10/n 🙏

Does this mean that autophagy findings from other model systems are irrelevant? Absolutely not. We need knowledge from *all* systems. I started my scientific career in yeast genetics (cancer biology) and have since published studies with data from mice, flies, human cells and

Longer-lived mammals have evolved under different selection pressures 🐁🚶‍♀️🚶. Complex mammalian tissues face unique challenges and must maintain homeostasis over months and years (if you're a lab mouse) and even decades (humans). So variation is an expected feature, not a bug.

So - what does all this mean in the wider context? Well, there is a lot of evidence that autophagy pathways generally decrease over the lifespan in different models throughout life 🪰🪱🧫. We think this is true. To be clear, we have no issue with this assertion. However... 7/n

We hope our map of mitophagy and macroautophagy in the aging brain will prove of high utility to researchers in both academia and industry who are actively working on the therapeutic modulation of these pathways, and have intentions to target the CNS. 6/n

We also profiled mitophagy and macroautophagy in different neuronal populations in vivo (e.g. A9, A10 DA neurons) and regional niches of astrocytes + microglia and also the CSF-producing choroid plexus of the aging brain... but one of the most interesting surprises was inhibitory

Anna observed the emergence of double-positive autolysosome and mitolysome subpopulations in different cell types around midlife. These appear to be "differentially acidified lysosomes", which increase throughout aging. There are clear parallels between this subpopulation and the

Anna profiled brain tissue from our mitophagy and autophagy reporter mice from 3-26 months and observed some big surprises. The take home message: mitopagy seems to be maintained throughout healthy brain aging, but there *are* region and cell specific shifts. We see📈in

First ‼️ shoutout to Anna Rappe (doctoral researcher) for her remarkable drive, dedication, and ingenuity in her inaugural first-author paper. It has been a pleasure to witness this project transform from an MSc thesis into a mature and exciting PhD (@DPBrainMind). 🌟 🎉🎓Here is

Excited to share our latest study published in @embojournal!!! 🙌🎉 We conducted a longitudinal analysis of physiological #mitophagy in healthy brain #aging, providing a deeper look at #autophagy pathways across neural space + time 🧠🔬 https://t.co/qeVRjvoK8i #mitochondria

Pexophagy is the new mitophagy! So happy – HIF1 upregulates NIX, which independently localises to mitochondria and peroxisomes to mediate their autophagy. Great work from @LeaPwilhelm and our collaborators in the labs of @patricia_boya and @AshToye_Bristol

Hot off the press - our latest review on #mitophagy in the #aging #brain by Anna Rappe and me. Many thanks to the editors and reviewers for their constructive feedback in @FrontCellDevBio. Check it out! 🧠♻️📚 https://t.co/svD9pz6CX3 #neuroscience @HelsinkiUniMed

Congratulations to our amazing student Anna Rappe, who was awarded the top MSc #neuroscience project in Europe at @FENSorg Forum 2022!! 🥰🧠🔬We are so so proud of you!! #wearehelsinkiuni #womeninstem @HelsinkiUniMed @helsinkiuni @HelsinkiWils #MyFENS2022

Super proud (!) of my student Anna Rappe for being awarded a best poster prize at #FENS2022 - highlighting all her hard work, dedication and the start of an exciting research journey! 🥂🎉🙌🧠 #mitophagy #neuroscience

Also - hat tip to my fellow islander, favourite Welshman and almost namesake...@pete_the_teapot for recommending the SMC! Was extremely valuable for us.