Matthew Tierney
@tierney788
Followers
135
Following
522
Media
4
Statuses
157
@RockefellerUniv stem cell biologist, proud @UofR, @UTAustin and @SBPgradschool alum.
New York, NY
Joined June 2010
1. Thrilled to share my latest work in @ScienceMagazine with @ElaineFuchsLab @RockefellerUniv showing how retinoic acid availability helps control stem cell fate decisions in wounded skin! A thread:
science.org
Retinoic acid dictates whether and when bipotent adult hair follicle stem cells pursue one cell fate versus another.
9
39
149
Huge thanks to #ISSCR2024 for giving me a chance to speak about my work in beautiful Hamburg! Also enjoyed a wonderful talk by @ElaineFuchsLab as always 👏🏻
0
5
28
We are thrilled to announce that the 2024 NY SKIN CLUB will be held on Dec 2nd, 2024. We look forward to another great meeting that brings together the skin researchers of the tri-state and beyond! Mark your calendars and details to follow soon!
0
4
5
Paper alert! In our new @ImmunityCP paper with @YMphoenix we discovered how hair follicle stem cells use CD80 to expand extrathymic Tregs, facilitating wound healing https://t.co/K4PdSDxmKt
cell.com
In skin injury, the inflammatory environment can impact repair mediated by skin stem cells. Luan, Truong, Vuchkovska, et al. show that hair follicle stem cells migrate into the wound, activate...
0
22
61
Thrilled to announce that @SynRegLab is recruiting a postdoctoral fellow to investigate mammalian wound regeneration. Genomics experience is beneficial, but not required. Please RT. https://t.co/8UqWmKI5Zd
woappilab.com
Research Technician position in wound physiology We are looking for a talented and motivated research technician to lead our efforts in the development of in vivo and in vitro wound models and skin...
We are hiring! Fully funded postdoctoral position in cellular wound regeneration. Apply!! https://t.co/FwjvCOw9Pk
0
33
46
Featured on our latest episode: Dr. Matthew Tierney (@tierney788) and a team in Dr. @ElaineFuchsLab showed how retinoic acid availability helps control #StemCell fate decisions in wounded skin. 📎 @ScienceMagazine: https://t.co/KMBaN2eFBR 🎙️: https://t.co/zws3UvjES1
0
6
22
📢Latest published paper from @ElaineFuchsLab on essential role for Vitamin A in wound repair & #StemCell function! 📢 Dr. Elaine Fuchs was awarded a 2020 #GairdnerAwards for her studies on the role of tissue stem cells in homeostasis, wound repair, inflammation & cancer.
In case you missed it: our latest paper published last week in @ScienceMagazine unveils how vitamin A regulates the biology of hair follicle stem cells. Find the free access link here 👇🏼 https://t.co/ug7HwjEOtW And a summary of our discoveries below: https://t.co/WSkTeoKQHe
0
2
8
In case you missed it: our latest paper published last week in @ScienceMagazine unveils how vitamin A regulates the biology of hair follicle stem cells. Find the free access link here 👇🏼 https://t.co/ug7HwjEOtW And a summary of our discoveries below: https://t.co/WSkTeoKQHe
rockefeller.edu
The transcription factor SOX9 is overly active in lung, skin, head and neck, and bone cancer.
1
28
141
#VitaminA regulates lineage plasticity in mouse hair follicle #stemcells (HFSCs) during wound healing. 1: ⬇️ Vitamin A signaling confers plasticity to HFSCs. 2: ⬆️ signaling allows HFSC differentiation into skin and hair cells. @ElaineFuchsLab @tierney788
https://t.co/Z6jdZ2Mk9Y
0
3
14
In this week’s #SciencePodcast🎙️ with @MichaelPriceSci, @boron110, @mclean_ka, and Matthew Tierney: ▶️ A dive into the genetic history of India ▶️ The role of vitamin A in skin repair 🎧 Listen here: https://t.co/xMoxUFKSlu
1
6
27
Don't miss @tierney788 of @ElaineFuchsLab on this week's #SciencePodcast! He discusses his latest work showing how retinoic acid availability helps control stem cell fate decisions in wounded skin.
In this week’s #SciencePodcast🎙️ with @MichaelPriceSci, @boron110, @mclean_ka, and Matthew Tierney: ▶️ A dive into the genetic history of India ▶️ The role of vitamin A in skin repair 🎧 Listen here: https://t.co/xMoxUFKSlu
0
3
10
Many thanks to everyone who worked on this, including @EpiYang @mdenizabdusselamoglu @InwhaBaek, funders @NIH_NIAMS @AFARorg @HHMINEWS, and our amazing editor @SMHSci. Truly a labor of love that wouldn’t have been possible without you all!
0
0
4
It also defines the minimal requirements needed to form mature hair cell types from stem cells outside their niches, providing a foundation for the continued development of novel platforms able to interrogate hard-to-study aspects of hair biology.
1
0
1
Altogether, this study demonstrates the potency of targeting lineage plasticity to affect stem cell behavior under reparative forms of stress and could help us identify new therapies that treat non-healing wounds and cancer.
1
0
1
We also learned that by manipulating vitamin A signaling in a wound, we could influence the relative rates of epidermal repair and hair growth by redirecting stem cell fate switching to these lineages.
1
0
1
Back to lineage plasticity- we asked if resolving this state would permit more physiological behaviors and found we could layer on known growth factors that govern hair cycling to successfully map their differentiation trajectories into different hair cell types.
1
0
1
Quick side note- much more on how SOX9 acts as a pioneer factor to accomplish this from a more mechanistic perspective in wonderful work performed by @EpiYang @NickGenomics here!
nature.com
Nature Cell Biology - Yang, Gomez et al. show that the pioneer factor SOX9 regulates the switch from epidermal stem cell to hair follicle stem cell fate by binding and opening hair follicle...
1
0
2
Using a high-throughput screening approach, we identified the vitamin A metabolite retinoic acid, which acted upstream of a gene network led by SOX9 to return hair follicle stem cells to their original fate and silence other (e.g. epidermal) lineages.
1
0
1
…collectively showing that the molecular signatures of lineage plasticity were recapitulated by the same culture conditions developed by Howard Green in the 1970s (still in use!), setting up a much more tractable system for us to model and manipulate it.
cell.com
Stem cell lineage infidelity occurs transiently in wounds and persists in cancer, driving wound repair and malignancy.
1
0
2
So, what signals support or restrict lineage plasticity in wounded skin? Our starting point came into focus from outstanding work carried out by @yejingge and others in the lab…
1
0
1
These recruited stem cells enter a more flexible state of lineage plasticity to adopt new fates (e.g. hair to epidermis), but this can lead to chronic states of repair and even some types of cancer if left unresolved.
1
0
1