Thilo Womelsdorf
@thiwomTO
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RT @KiaBanaie: GUI walkthrough & tutorial video here:.Code & install instructions on GitHub:
github.com
KIASORT: Knowledge-Integrated Automated Spike Sorting for Geometry-Free Neuron Tracking - banaiek/KIASORT
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RT @KiaBanaie: š šPreprint out now on bioRxiv!.āKIASORT: Knowledge-Integrated Automated Spike Sorting for Geometry-Free Neuron Trackingā. Bā¦.
biorxiv.org
Identifying single units from extracellularly recorded neural signals is critical for understanding brain circuit dynamics. With the advancements of large-scale recordings, efficient and precise...
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Notable: mental re-ordering (swapping) was more likely with better learning the initial sequence (=memory) (otherwise NHPs keep using serial chaining strategy) and correlates with working memory performance - kudos to Xuan, Adam and Seema for pulling this off ! 2 / 2.
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New paper shows how nonhuman primates learn (5-) object sequences and use context cues to mentally re-order objects within a learned sequence ā showing that NHPs form non-spatial cognitive maps 1 / 2
journals.plos.org
Compared to humans, non-human primates appear less able to mentally rearrange items to new, non-adjacent temporal positions. This study shows that macaques can learn to rearrange members of 5-object...
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Overall, the effects suggests that stimulation induced uncertainty in the ACC (with few exceptions) and in striatum boosted feature-specific credit assignment and updating of attentional priorities. Kudos to Louis, Kia, Charlie, Adam and Paul for pulling this off.
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Modeling suggests stimulation improved/impaired directed exploration/information gathering of relevant objects and the updating of feature values. Recordings showed ACC firing tracked feature uncertainty and error history, while striatum tracked stronger feature values of objects.
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New paper shows causal effects of gaze-contingent stimulation on learning feature-based attention: Treuting et al. (2025) Adaptive Reinforcement Learning is causally supported by Anterior Cingulate Cortex and Striatum. Neuron .1/2.
cell.com
Treuting et al. show that microstimulation in ACC and striatum causally affects the learning and updating of feature-based attention. ACC stimulation impairs exploring relevant objects, which is...
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RT @SAbbaspoor: Experience reorganizes content-specific memory traces in macaques šš§ . @perpl_lab @AymanAljishi .
biorxiv.org
Memory formation requires neural activity reorganization during experience that persists in sleep. How these processes promote learning while preserving established memories remains unclear. We...
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RT @perpl_lab: Humor me: Iām reactivating the latest preprint from the lab (itza ānewā trace) š¤.
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RT @ESI_Frankfurt: šØ New @ESI_Frankfurt paper out today inĀ Cell Reports! š§ Learn how PV+ & Sst+ interneurons shape Gamma Oscillations in viā¦.
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RT @perpl_lab: What makes memories lastādynamic ensembles or static synapses? | The Transmitter: Neuroscience News andā¦ .
thetransmitter.org
Teasing out how different subfields conceptualize central terms might help move this long-standing debate forward. I asked eight scientists to weigh in.
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RT @SAbbaspoor: Excited to share that the latest @perpl_lab paper is published in @CellReports. We describe the dynamics of superficial andā¦.
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RT @RudebeckLab: Led by Satoka Fujimoto and with @RussBEneuro and @HelenMaybergMD our first paper on the effects of deep brain stimulationā¦.
biorxiv.org
Deep brain stimulation (DBS) is an emerging therapeutic option for treatment resistant neurological and psychiatric disorders, most notably depression. Despite this, little is known about the...
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The conclusion is the ACC causally meta-adjusts learning strategies during periods of uncertainty to infer which objects to choose/attend/explore for best outcomes. kudos to @LTreuting44120 and the team with @KiaBanaie to pull this off!! 3/3.
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An adaptive RL/WM learning model suggests ACC-stimulation had primary effects: impairing integration of feature specific prediction errors over time; and secondary effects: impairing meta-adjustment of exploration-over-exploitation AND the use of working memory for learning. 2/3.
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If you are interested in how the Anterior Cingulate Cortex affects behavior: Brief ACC-stimulation when an object is fixated changes inferring the relevance of that object over other objects, i.e. ACC reduces uncertainty about the objects' value. 1/3.
biorxiv.org
Short Summary The anterior cingulate cortex encodes object-specific reward histories, but how this information contributes to behavior has remained unclear. This paper shows that micro-stimulating...
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RT @BastosLabNeuro: Group photo of inaugural Multi-Area, high-Density, Laminar Neurophysiology (MaDeLaNe) workshop @VanderbiltU. Thanks @maā¦.
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RT @SAbbaspoor: Check out our new paper on "state-dependent circuit dynamics of superficial and deep CA1 pyramidal cells in macaques" now aā¦.
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Demo of a new Multi-task cognitive profiling platform for NHP+humans at #SfN2023 (booth 120, brainsight) and poster XX37 wed 8-12: see also
biorxiv.org
Background Understanding the neurobiological substrates of psychiatric disorders requires comprehensive evaluations of cognitive and motivational functions in preclinical research settings. The...
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