There's a progression of every lab leak argument -- because the evidence for lab leak is bad, the conspiracy has to grow.
I pointed out a flaw in the lab leak theory, by referencing a natural virus, Lyra11, found way back in 2011. So the theory changed to say that virus is fake.
@Bryce_Nickels
@jonatanpallesen
While responding to you, I literally just got 2 responses from people trying to sell ivermectin online.
That concerns me. Peter Hotez does not.
I tried simulating the early covid epidemic in Wuhan to better understand a few questions:
When did covid start?
Did it start with 2 introductions of the virus, or only one?
When I did my cost-benefit analysis of the Floyd protests, I did not take into account an explosion in the number of homicides of children.
But it's increasingly hard to ignore the likelihood that this was indeed a cost.
Over 4 yrs after being first to publicly release SARS-CoV-2 genome, Yong-Zhen Zhang just published large set of viral seqs from first stage of COVID-19 outbreak in China
He uses data to suggest scenarios re early outbreak & root of viral phylogenetic tree
@yashkaf
@Rootclaim
My calculation was basically, "if you can multiply 10 things for the lab side to make it 1 in 700 million, I can multiply 20 things for zoonosis".
And I spent a lot of the debate saying that the world isn't that simple, both politely and not so politely:
@BretWeinstein
@clairlemon
@mtaibbi
Bret, there's a lot you have to explain to make this convincing.
1. Why is the vaccine more dangerous than natural infection, with regards to ADE? Seems like reinfection should be similarly dangerous in either case.
Lab leak supporters aren't very good at understanding science or data, but they are really good at creating controversy.
The latest manufactured controversy involves a diagram I used in the Rootclaim debate which ended up in Scott Alexander's blog post:
@arguablywrong
@slatestarcodex
It gets worse. As evidence against an earlier introduction,
@slatestarcodex
presents a doctored version of Fig. 3E from Pekar et al.'s "Timing the SARS-CoV-2 index case in Hubei province", 2021.
But where does the 700 viruses number come from?
I thought this one would take a lot of effort to track down, but it turns out that Daszak already had a thread up 4 years ago, describing the same 700 sequences!
@BretWeinstein
@clairlemon
@mtaibbi
6. To eradicate covid, you need to get most of the US taking pills. Do you expect people who won't get 2 shots or even wear masks to all diligently take pills every week until the virus is gone? To give the pills to their kids?
Understanding the science can get complicated, but I think it can be easier to recognize patterns in how people tell stories.
Those patterns can often help you guess the right answer.
Anyways, that's all a bit complicated.
It took me a while to understand this stuff and I see a lot of confusion about it on Twitter.
I hope this thread sheds some light on the topic.
@mtaibbi
@clairlemon
The problem is that false claims spread faster than the rebuttals.
Like, Steve Kirsch has made a false claim that the vaccines killed 25,000 people.
I debunked it on twitter and wrote a blog post:
Avi debunked it in debate.
But it turns out that the paper was written and submitted in 2019.
It was submitted before any lab leak would have happened and before the lab would have anything to hide.
Anyways, I'm not a virologist, just a guy who's interested in covid misinformation.
I often find the way that people tell stories more interesting than the data itself.
@BradCLemley
@clairlemon
@BretWeinstein
HIV is up to 40 million cases and still 100% fatal without treatment. Transmits long before symptoms start, so there's no evolutionary pressure on lethality.
Covid also does some presymptomatic transmission. We have no idea if it will evolve to be more or less deadly.
Every time, there's a hook, a good story -- "look at this secret early data".
When level-headed scientists investigate it, it always turns out to not actually be early or important.
But the story often spreads faster than any careful analysis.
We also have a copy of the lab's database, from 2018. As part of an unpublished paper, the viruses were saved on a foreign server and released a few years later.
There was also no secret virus in that one.
The main reason I ended up rejecting the lab leak theory is that the evidence does not hold up -- the facts point away from the lab and towards zoonosis at a wet market.
But you can also get to the right conclusion just by noticing who's promoting the theory and what else they believe.
I.e. one of the big accounts promoting it is also a 9/11 truther who thinks HIV was caused by vaccines:
@BretWeinstein
@clairlemon
@mtaibbi
7. Some people will inevitably start to make videos telling us that the pills are toxic, or part of a plot to sterilize us all. Do you think YouTube should censor those?
We also know that those were collected over more than a decade, and many were published along the way.
So the most obvious explanation is that Daszak was referring to the same set of samples, not 15,000 secret samples that were collected over years and never mentioned.
@yashkaf
@Rootclaim
We actually considered you in our first round of judge ideas.
I proposed Scott, Zvi, Kelsey Piper, Julia Galef, and you as rationalists who'd be good for the role.
Saar said you were friends with him, so it wouldn't be a fair choice.
@thebadstats
@BretWeinstein
I thought the challenge was when he asked if you were a coward.
And then Bret already lost by refusing to have you on his show.
Covid origins sleuths used a FOIA request to get the original copy of the paper.
There was no secret virus in it, even DRASTIC members will tell you that:
The paper that Daszak is referencing in that thread (Latinne et al) wasn't published until mid 2020.
Of course you would think that the lab would try to cover up any sequence used to create SARS-CoV-2.
But learning about virology takes work and spotting misinformation is much easier.
If you're looking for shortcuts to figuring out the truth, it's a lot easier to focus on who's pushing the lab leak theory, why they're doing it, and whether they have any filter for truth --
Covid origins is a confusing topic, because the science is complicated and the media incentives are bad (lab leak stories always get more clicks than stories about the wildlife trade)
I did the debate to try to help communicate the science, and I'll keep writing about the issue
@BretWeinstein
@clairlemon
@mtaibbi
2. Wouldn't herd immunity via covid infection drive immune escape just like vaccination? Immunity via vaccines should just get us to the exact same place faster, with less deaths.
You can imagine some secret program where the lab did gain of function research on other viruses, separate from the viruses that they were sequencing and publishing, but that certainly doesn't seem likely to me.
The current market origin theory is that Lineage A and Lineage B are 2 spillovers from animals at the Huanan market.
That explains all the data we have, including why the genetic clock looks reversed -- even though A evolved first in the animal, B spilled over first:
I'd point out a few things here. Notice that they're including both CC and TT intermediates.
The original virus could only be one or the other, so these are mutually inconsistent claims.
The strategy here is very much, "throw things at the wall and see what sticks".
All the early covid genomes can be divided up into Lineage A and Lineage B.
This is my favorite visualization of the early genomes (up to mid February), from
@acritschristoph
.
A is the cluster in the upper left, B is the larger cluster, on the lower right:
Do they update their model when they see a contradiction or flaw in their theory?
Or do they just endorse a larger conspiracy theory to cover up the mistake?
Because that feature was found in nature, Ridley suggested that maybe the lab secretly had that virus.
That makes it hard to disprove the lab leak theory. As soon as some evidence is found in nature, the lab leak theory expands and says the lab had already found that evidence.
For those attached to the lab leak theory, this should make you wonder a little.
Many people think that China used a market outbreak to hide a lab leak.
But, if that was the goal, why would these errors all point in the wrong direction -- away from the market, not towards it?
This is the gimmick behind "bayesian reasoning".
If you arbitrarily assign high odds to the things you want to be important, and low odds to the things you don't want to be true, you can make your analysis support anything.
@BretWeinstein
@clairlemon
@mtaibbi
14. I do hope you're right that ivermectin works, and i do hope the world uses it for treatment if it does. The world desperately needs cheap and effective treatments. But it's not the least bit clear that we can get by without vaccination.
The other problem is that these proCov2 genomes were not found early. I labelled the red and blue dots from that previous diagram (and measured mutations relative to RATG-13)
The A+29095T genomes are purple, the A+18060T genomes are orange. Those weren't found until January.
Bloom is now promoting a new paper with data from Shanghai.
First off, it's not early data. It's from late January and beyond.
There may be some data in China from Nov or early Dec that would help solve the origins question, but late January data from another city will not.
The red line (all excess deaths) is above the black line (covid deaths) in all these countries except Sweden, and the gap is still growing in some.
Does this simply mean lockdowns killed more people than covid?
@DrJBhattacharya
?
Every case at the Huanan market which was sequenced had Lineage B.
Some people theorized that Lineage A started outside the market.
One theory said that A came from a different market in Wuhan.
Another theory said that A started at the lab and mutated to B at the market.
@BretWeinstein
@clairlemon
@mtaibbi
11. If you can't eradicate it, and we don't have antibodies, then we're all taking pills forever. If we stop, then 1 case can sweep the world in 6 months.
The virus was publicly known by the end of December.
But the Wuhan government didn't react until late January.
They let Chinese New Years celebrations happen.
People in Wuhan tried to set a record for largest potluck, with 40,000 families.
The second known lineage A case stayed at a hotel near the market for 5 days before getting sick.
The 3rd lineage A sample was taken at a stall at the Huanan market.
So, the only early places that Lineage A was found are at or near the market.
We don't have a lot of data on where lineage A was, in December 2019, as we only found 2 sequenced lineage A cases.
One of the two cases lived 2 km away from the market, and was found with an unbiased search:
(F in this map is for family infections)
It's also a question of which animals people farm and eat.
People in Texas farm different animals than in China.
(Like lots of cows, which are currently getting infected with H5N1, in a possible prelude to our next pandemic)
When I first heard the lab leak theory, in 2020, I didn't want to dismiss it without digging
Seemed possible for a lab to make a virus
If only a few people knew, maybe they could cover that up
But not the case when your conspiracy includes global scientists, corporations, etc.
In 2021, scientists found bat viruses in Laos, with almost the same RBD as SARS2.
That eliminated any need for a pangolin chimera theory.
For most scientists, that was a clear sign that this feature came naturally from bats.
All this evidence does make sense, though, for the natural hypothesis.
SARS-CoV-2 was able to jump from bats to intermediate host to humans, because it's one of the viruses with wide ACE2 binding.
It has some features of a respiratory virus in that intermediate host.
We can also look at other scientists and what they were doing, during that time.
The Wuhan scientists were acting normally the whole time, going to conferences, going out to dinner, hosting a camp for students at the WIV:
2⃣ On Jan 12-15 2020, the Wuhan Institute of Virology hosted a winter camp for college students; 55 took part!
Meanwhile, the virus was spreading in the city. You'd think they would have cancelled the event, had they known that SARS-CoV-2 had leaked from their facilities... ▫️4/
@BretWeinstein
@clairlemon
@mtaibbi
8. You need to eradicate covid around the world, as well. What's your plan for countries that haven't even been able to get rid of polio?
In January, everyone knows about the virus and he's still talking about infecting humanized mice with coronaviruses:
(He's referring to work done at UNC, not in Wuhan).
Some of these are actually from Wuhan, so at first I thought maybe they had discovered something important and new.
But then I looked up those genomes in GISAID and discovered... the Wuhan ones were also sequenced in Sichuan!
So it's the same problem.
This also isn't the first time that people have taken Daszak's words out of context.
Daszak tweeted about 50 SARS related viruses, back in November 2019:
Not true - we’ve made great progress with bat SARS-related CoVs, ID’ing >50 novel strains, sequencing spike protein genes, ID’ing ones that bind to human cells, using recombinant viruses/humanized mice to see SARS-like signs, and showing some don’t respond to MAbs, vaccines...
You can also get a feel for when the two lineages first started, just by looking at the viral diversity over time -- when each one first starts, the virus has no diversity.
As it infects more people, there are more mutations and more diversity:
@KimDotcom
@SamHarrisOrg
My firstborn child died in my arms. I felt his last heartbeat.
I have no mercy for anyone who would use the deaths of children for gain, politics or fame.
@RCAFDM
@sodhuxley
@Steve_Sailer
And no corresponding increases elsewhere in the world.
In Mexico, the murder rate went down by 3% in 2020. In Canada, up by 7%. In Brazil, up by 4%. In the UK, up by 7%. In Germany, up by 4%.
In the US, murders went up by 29%. And the rise was primarily in the black community.
As of 2021, there was a mystery -- Lineage A is 2 mutations closer to known bat viruses but Lineage B seemed to start earlier.
A review paper in 2021 used a bayesian analysis to estimate 96% odds that Lineage B came first.
But that's not everyone -- someone else in the lab leak community came up with a theory that BANAL-52 is fake.
And Matt Ridley, who previously said the BANAL viruses made the lab leak theory stronger, now said it was vitally important to consider that these might be fake:
That analysis would rule out most of the simple lab leak scenarios.
The lab can't just plug a furin cleavage site into a bat virus.
Now the lab needs to be working on some other animal, or they need to follow some complicated process to alter the bat virus.