Sam Mestern
@smestern
Followers
192
Following
1K
Media
12
Statuses
206
Neuroscience @ Western U Studying Stress with Patch Clamp Electrophysiology. Inoue Lab. He/Him. Former Carleton U Raven!
Joined July 2020
NWB just turned 10 years old! Researchers worldwide have downloaded 1.9 PB of NWB data from the @DANDIArchive. This animation shows the reach of NWB, facilitating collaboration across the globe. What impact has open neurophysiology data had on your science? Share your stories! 🧠
0
5
15
#eNeuro | Calcium Dynamics in Hypothalamic Paraventricular Oxytocin Neurons and Astrocytes Associated with Social and Stress Stimuli https://t.co/FU1tWXNcsq
eneuro.org
Activation of hypothalamic paraventricular oxytocin (OXTPVN) neurons by social or stress stimuli triggers OXT release to promote social investigation and buffer adverse effects of stress, respectiv...
0
12
33
The Hypothalamus, a phylogenetically ancient brain region where action potentials and hormones interface to produce hybrid signalling cascades; ultimately enabling our responses to stress. Check Hiro's paper. Amazing work led by @NeuroStress_Lab.
biorxiv.org
The elevation of glucocorticoids is a hallmark of stress, arising from the integration of rapid neuronal signals into sustained hormonal outputs. A key interface for this neuroendocrine signal...
0
6
19
Check out our new perspective paper on metastability in neuroscience published @PhysRevE
https://t.co/HgSZpKS2Pf
0
1
5
Last week, I may have DEI’d too close to the sun and attracted anti-NIH folks to my profile who then claimed that my research is useless and a waste of time and money. I beg to differ! Allow me to explain in lay terms how my research in mice is relevant to human health: 🧵
My PhD work is out! How do mothers balance tending to their own needs, such as eating, and taking care of their offspring? We examined the link between feeding and parenting neural circuits and how they are modulated postpartum in mice 🧵 (1/9) PREPRINT: https://t.co/ICINJIAb5u
17
71
891
🚨 Exciting news! @NeuroStress_Lab & @Timothy_Bussey have received @CIHR_IRSC funding to explore the role of the prefrontal cortex in behavioral selection under stress. This research could unlock new insights into how stress impacts decision-making! 🧠💡#Neuroscience #Stress
0
2
6
Excited to share my latest work with @DiedrichsenJorn and @andpru. In this work, we ask whether motor sequence learning is motoric at all! Check out the 🧵version of the abstract: https://t.co/SfnqgzyR8e 1/n
biorxiv.org
Learning new sequential movements is a fundamental skill for many animals. Although the behavioral manifestations of sequence learning are clear, the underlying mechanisms remain poorly understood....
4
22
56
Evolution of the visual system has permeated the basic processing unit in the neocortex, the single neuron. A team effort @nxwm_network. Single neuron diversity supports area functional specialization along the visual cortical pathways | bioRxiv
biorxiv.org
Humans and other primates have specialized visual pathways composed of interconnected cortical areas. The input area V1 contains neurons that encode basic visual features, whereas downstream in the...
1
4
19
Congrats @smestern !! Awesome to see @NeuroCarleton alumni do great things!!
Congrats to @SMestern, Ph.D. student at @WesternU, for winning the MapMySpikes challenge! His tool, PatchOTDA, excelled in mapping electrophysiological data to molecular properties. 🧠🏆 More on his tool and the MapMySpikes challenge: https://t.co/Q46zWrFTwv
0
2
7
If you have any questions, want to impletment it yourself, or just want to talk about cool patch-clamp data & open science feel free to contact me!
1
0
2
I’m really excited to share this open-science side project I’ve been working on related to patch-clamp electrophysiology! If you’re into this or have some data you’d like to experiment with, I’d love for you to check it out. Big thanks to Allen Institute for the opportunity!
Congrats to @SMestern, Ph.D. student at @WesternU, for winning the MapMySpikes challenge! His tool, PatchOTDA, excelled in mapping electrophysiological data to molecular properties. 🧠🏆 More on his tool and the MapMySpikes challenge: https://t.co/Q46zWrFTwv
3
3
13
Congrats to @SMestern, Ph.D. student at @WesternU, for winning the MapMySpikes challenge! His tool, PatchOTDA, excelled in mapping electrophysiological data to molecular properties. 🧠🏆 More on his tool and the MapMySpikes challenge: https://t.co/Q46zWrFTwv
0
1
6
Our group @WesternU and @FieldsInstitute Lab for Network Science has postdoctoral and graduate research positions available. We are looking for scientists to bring together applied mathematics, neural data, and neural networks. Join our collaborative team!
2
13
28
I'm super excited to share this paper just preprinted by my group! We used a ton of post-mortem datasets (bulk RNAseq, snRNAseq, FISH, LCMseq) from PsychEncode cohorts to try to understand what's happening to GABAergic interneuron subtypes in human schizophrenia.
Cortical GABAergic neuron dysregulation in schizophrenia is age dependent https://t.co/nGWkj3mEYo
#medRxiv
3
16
92
We're at #SfN24! Come visit us at booth #1865 joint with @DANDIarchive and check out our showcase of NWB-integrated tools: NWB GUIDE, OpenEphys, AqNWB, HERD, NeuroSift, and MATLAB analyses. We also have several posters on Tues. See details below:
0
7
10
Beyond grateful to share two co-first author papers that came out in @Nature!! With @AmitVinograd, we provide causal evidence for a line attractor in the mammalian brain! And with @MengyuLiu96, we show that line attractors might be a common mechanism for emotions beyond anger!
7
31
186
Check out this preprint and 🧵 on mapping the "zone of uncertainty" using @HumanConnectome data and employing gradient-based🌈 and spectral clustering methods. Work led by @RoyHaast and @JasonKai. Comments/suggestions welcome!🧠🔬
0
7
35
My #AI4Neuro magnum opus: Discovery of spiking network model parameters constrained by neural recordings, using simulation-based inference & generative “AI”. (aka the answer to “how the f did you end up in Tübingen?”) Here's what we have in store: https://t.co/UpnjVaLp8G
10
54
209