Motoyuki Hattori (服部素之)
@HattoriLab
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Structural biology and associated tool development. Magnesium and ATP. Professor at Fudan Univ. Lab Plasmids: https://t.co/oqCZdgBcs8
Shanghai
Joined January 2022
The PDBs entries of the de novo designed proteins in our recent preprint were released in advance, including that of the unique beta-barrel structure containing two internal alpha-helices!.
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RT @yuki_sugi: Preprint posted:. We report diverse nucleoprotein complex structures, with and without RNA, from Borna disease virus 1, a vi….
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Excited to share our new preprint revealing a previously hidden “mini-N” subclass of the Mg²⁺ channel MgtE by genome mining and showing how an AI-designed de novo fusion protein enabled its purification for structural studies! Congrats to all authors!
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RT @Yoshi__Ichikawa: We have posted our new #preprint regarding the track recognition mechanism of dynein-2 that works in #cilia on bioRxiv….
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Featured in PREVIEW! Congratulations to all in the project!
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今年のノーベル賞にもなったAlphaFoldを活用して輸送体タンパク質の構造変化を予測し、各種機能解析で予測検証をした論文を発表しました。AlphaFoldを自分の研究に活用したいが具体的にどう使えばいいのかわからないという生命科学研究者にオススメです。京大三木研と復旦王研との共同研究になります。.
Happy to share our work on the AlphaFold-based analysis of the conformational dynamics of CNNM/CorC Mg2+ transporters. Great collaboration with Miki lab at Kyoto Univ and Wang lab at Fudan. Congrats to Ma and all others! Here is the downloadable link.
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RT @Structure_CP: Online now! AI-driven mechanistic analysis of conformational dynamics in CNNM/CorC Mg2+ transporters .
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Happy to share our work on the AlphaFold-based analysis of the conformational dynamics of CNNM/CorC Mg2+ transporters. Great collaboration with Miki lab at Kyoto Univ and Wang lab at Fudan. Congrats to Ma and all others! Here is the downloadable link.
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コラボのきっかけになったツイートです。元々は学生実習にde novo protein designをやろうと予備実験をしていたのですが、それが共同研究につながるというのは貴重な体験でした。.
We recently tested this notebook. The predicted and experimental structures are well consistent! We highly recommend this, as well as the one for RFdiffusion, as excellent options for everybody to start de novo protein design!
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共同研究論文がScience誌に。@chrisfrank662 @sokrypton @hendrik_dietz 先生らのde novo protein design手法開発です。おめでとうございます。当研究室は院生のZhaoさんが設計と構造解析の一部を担当。彼らのプレプリントをみて行った実験結果のツイートがコラボのきっかけに.
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RT @chrisfrank662: Finally, out in @ScienceMagazine today, our work on de novo protein design. Together with @HattoriLab , @sokrypton & @….
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RT @MemProtPDB: Cryo-EM structure of the zinc-activated channel (ZAC) in the Cys-loop receptor superfamily | PNAS . .
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The ZAC sample in amphipol showed a severe orientation bias, while the sample in nanodisc contained a different orientation but did not provide the high resolution map. We used both datasets to determine the structure. Here is a related-review article. 3/3
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Some technical notes. To screen the expression of ZAC orthologs with high expression level and stability, we previously developed FSEC-Nb, a nanobody-based FSEC derivative that does not require direct GFP fusion to target proteins. FSEC-Nb worked well! 2/3.
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Thrilled to share our work on the first cryo-EM structure of the zinc-activated channel (ZAC), the least characterized member in the Cys-loop receptor! @PNASNews Great collaboration with Wang lab at CPU. Congrats to Jin and all others in the team! 1/3.
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膜タンパク精製試料調製のためのFSEC法による発現スクリーニングの総説をJMB誌に正式発表しました。クライオ電顕時代のFSECの応用例の解説に加え、今年のノーベル賞にもなったAlphaFoldなどのAIベースの構造予測やタンパク質デザインへのFSEC法の応用についても議論しています。ご興味のある方は是非。
Our review article “Recent advances in expression screening and sample evaluation for structural studies of membrane proteins” is out in @JMolBiol. We discussed the recent advances and new applications of FSEC. Congrats to Huang and Zhang!.#OpenAccess.
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RT @NobelPrize: BREAKING NEWS.The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to….
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RT @Yoshi__Ichikawa: Collaborative work is now posted on bioRxiv! .Following our previous work in Science Advances ….
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Our review article “Recent advances in expression screening and sample evaluation for structural studies of membrane proteins” is out in @JMolBiol. We discussed the recent advances and new applications of FSEC. Congrats to Huang and Zhang!.#OpenAccess.
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