There is a kind of MCD, or a kind of MN, with sparse subepithelial deposits, but diffuse FPE. Acute disease onset, sensitive to steroids, but relapse or spontaneous remission. What would you categorize them under?#renalpath

The paucity of tubular profiles in the renal medulla should raise the consideration of a hemoglobinopathy, especially in those with African ancestry, such as this patient. Notably, the cortex has much less tubular loss. RBC sickling occurs in the medulla where it's more hypoxic

Granulomar IN: M, 18y, UP 1.5g, Scr 648umol/L, Hb77g/L, C3 0.8, increased IgG 22.7 (G1 14.8, G4 4.7), IgA 5.3. ANA-, ANCA-; no virus infection, no eye lesions, no related meds. LM: clear nodules mainly surrounding tubules, no giant cells, no caseous necrosis. Cause? #renalpath

Unusual granular casts with annular appearance. Light chain, hemoglobin, myoglobin, chromogranin casts excluded. Patient on IV vancomycin. Suspicious for vancomycin cast nephropathy. https://t.co/WUG0cLnawH #renalpath #pathtwitter #nephrology

One of my favorite biopsy artifacts. Displaced tubular epithelial cells in glomerular capillary loops mimicking a thrombus. #renalpath #pathwitter #nephrology.

Differential Dx of pauci-immune GN with "full house" mesangial staining from: https://t.co/l93PaUa8w9

This biopsy shows the characteristic features of uric acid nephropathy (commonly known as gout), which results from precipitation of uric acid in the kidney parenchyma. Tophi frequently occur in the medulla, and usually consist of central regions of acellular, granular material

C3 GN in 11 yo boy with proteinuria, hypertension, low C3 (normal C4). EM shows irregular thickening of glomerular capillary wall and mesangial expansion by electron dense deposits. The deposits are somewhat ill-defined with early sign of resorption.

AJKD Atlas of Renal Pathology: Crystalglobulin-Induced Nephropathy https://t.co/TyG5KPwziJ (FREE) @podocytes @AlpersCharles @AgnesFogo #RenalPath Image: Large bright eosinophilic crystals within glomerular capillaries (arrow, Jones silver stain)

Cryofibrinogen-associated nephropathy shows MPGN pattern with no Igs and complement staining. Unique tubular structure with central bores and multiple layers, larger than those in immunotactoid GN by EM

29y male，body builder, 1-1.7g proteinuria, Alb normal, Scr slightly increased (92.9-97.2-100.3) umol/L. LM: 2 glom with FSGS lesion, but what is the pie-like granular lesion in interstitium? #renalpath #askrenalpath

Happy Halloween! Dr. Bijol observed a ghoulish case of amyloid spicules by electron microscopy. #pathx #nephx #renalpath

Severe vascular rejection hiding in the IF tissue. Fibrinoid necrosis really pops on the H&E and further confirmed by fibrinogen IF. #renalpath #pathtwitter #nephrology

Complement- Kidney biopsy is grossly inadequate when it comes to complement: we stain for only C3/C1q! LMD/MS can: -determine complement pathways -determine burden of complement -Activated vs entrapped complement -Assess complement regulating proteins https://t.co/aGD0K0i1Dt

It's worth the trip for more friendships!

Numerous clinical associations of collapsing glomerulopathy - great overview by Dr. Kelly Smith at @GlomCon :

The 2nd East Asia Renal Pathology Conference has started! Beautiful case presentation was given from @shary_tang about Cryofibrinogen-associated glomerulonephritis with paraproteinemia - PubMed

Cholesterol emboli involving the kidney may manifest clinically as acute kidney injury, hematuria, proteinuria (both non-nephrotic and nephrotic range), and even new onset hypertension. This biopsy illustrates a rare example of glomerular involvement. Most emboli are identified

What Dr. Singh saw #UnderTheScope today: Plasma cell-rich interstitial nephritis in a patient with Sjogren's syndrome.  #kidneypath #renalpath #pathology #nephtwitter #pathx #nephx

What Dr. Singh saw #UnderTheScope today: GBM spicules "eyelashes" in a case of AL lambda amyloidosis. #renalpath #kidneypath #pathx #nephtwitter #nephx