Jonathan Zuckerman MD PhD
@JZRenalPath
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Service Chief, Renal Pathology, UCLA Department of Pathology and Laboratory Medicine. Views are my own.
Los Angeles, CA
Joined July 2018
So many eosinophils in this case of tubulointerstitial nephritis secondary to recent antibiotic administration. Few tiny granulomas as well. Eos seen in EM as well. #renalpath #pathtwitter #nephrology
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The picture shows tissue submitted for routine immunofluorescence (fibrinogen stain is shown). Careful inspection confirms that this is an artery cross section which contains abnormal intraluminal tissue elements with numerous cleft-like spaces (see arrow). Although no immune
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Latest @Pathologists evidence-based guidelines for Laboratory Workup of Amyloidosis is out.
meridian.allenpress.com
Context.—. Treatments are available for common forms of systemic amyloidosis that show promise for extending and improving the quality of life for patients. Early diagnosis and accurate identificat...
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The paucity of tubular profiles in the renal medulla should raise the consideration of a hemoglobinopathy, especially in those with African ancestry, such as this patient. Notably, the cortex has much less tubular loss. RBC sickling occurs in the medulla where it's more hypoxic
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Granulomar IN: M, 18y, UP 1.5g, Scr 648umol/L, Hb77g/L, C3 0.8, increased IgG 22.7 (G1 14.8, G4 4.7), IgA 5.3. ANA-, ANCA-; no virus infection, no eye lesions, no related meds. LM: clear nodules mainly surrounding tubules, no giant cells, no caseous necrosis. Cause? #renalpath
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Unfortunate but not rare IgAN presentation. Pt in their 30's, no PMHx, presented with HTN emergency, CKD, hematuria, proteinuria. Advanced IgAN with severe IFTA, focal active crescents (M1 E1 S1 T2 C1). Wish we could catch these cases earlier. #renalpath #pathtwitter #nephrology
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#ASCP2025 Proud mentor moment! @cullen_lilley and @LJMiller_MD are taking the stage to show how pathology and the lab power every corner of healthcare. From quality to ethics to smart test use they are giving teams the playbook for better communication and real collaboration.
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The RPS is inviting you to a webinar Spectrum of Transplant Rejection: Towards the Implementation of Activity and Chronicity Indices Tuesday, December 2, 2025 8:00 AM PST / 11:00 AM EST / 5:00 PM CET For more info & to register: https://t.co/HrCbWI9yCr
#renalpath #PathTwitter
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One of my favorite biopsy artifacts. Displaced tubular epithelial cells in glomerular capillary loops mimicking a thrombus. #renalpath #pathwitter #nephrology.
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@JZRenalPath One of our fellows just presented an interesting MGMID case @ASNKidney Week
This was a really interesting MGMID case Young man with CML with no positive rheum serologies or paraproteinemia who developed proteinuria while on dasatinib Biopsy showed MGMID, switched the dasatanib to bosutinib with onc and proteinuria resolved #KidneyWk
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Unusual granular casts with annular appearance. Light chain, hemoglobin, myoglobin, chromogranin casts excluded. Patient on IV vancomycin. Suspicious for vancomycin cast nephropathy. https://t.co/WUG0cLnawH
#renalpath #pathtwitter #nephrology
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Typically occurs in young women with vague autoimmune history. Has not been associated with MGUS, plasma cell dyscrasias, or lymphomas. Deposits + for SAP. See references here: . https://t.co/CNa8qlPQkb
https://t.co/qN4wxgDJp3
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Diagnosis unmasked. Young F with 2g proteinuria, weak +dsDNA. Membranous pattern, IF with C3 dominant staining. Pronase IF --> IgG-k. Membranous-like glomerulopathy with masked monotypic IgG-k deposits. Considered to be autoimmune; not MGRS. #renalpath #pathtwitter #nephrology.
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BK nephropathy Clues: - Heavy but focal tubulointerstitial inflammation - Increased plasma cells - Viral cytopathic change - Features of CNI toxicity ->over immunosuppression (isometric vacuolization shown here) -SV40 IHC confirmatory #renalpath #pathtwitter #nephrology
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Linear staining in GBM, Bowman capsule, TBM in pt with heavy chain deposition disease. Granular/smudgy staining noted in mesangium
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Arteriole with features of a old recanalized thombus in a transplant kidney biopsy. Multiple slit like vascular spaces within the fibrotic lumen. Not a lesion I see often. Pt had clinically diagnosed TMA a few months prior. #renalpath #pathtwitter #nephrology
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NELL-1 IHC can also be tricky to interpret as there is significant podocyte cytoplasmic staining in the negative control. Must show granular capillary wall deposits which match deposits by IF and EM. #renalpath #pathwtitter #nephrology
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Illustrative example of a segmental membranous nephropathy pattern (segmental granular IgG staining) which is often seen with NELL-1+ (IHC) MN as in this case. Deposits present in only some loops by EM. #renalpath #pathtwitter #nephrology
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Dual-antigen MN - Clinical lab test of laser microdissection & mass spectrometry revealed 2 antigens in ~2.6% PLA2R negative MN - The antigens correspond to underlying disease - Further studies needed to study outcomes Dual-Antigen Membranous Nephropathy
kidney-international.org
Most newly discovered membranous nephropathy (MN) antigens have been mutually exclusive, but there are rare cases of dual antigen MN based on immunohistochemistry (IHC)/immunofluorescence (IF) or...
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