Roshan Lal Shrestha
@rosh_lal
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Scientist @NCIResearchCtr, translational med, #chromosomal_instability, #cancer #aneuploidy, Founder @ChdsNepal, Adj Faculty @MAHE_Manipal @Cambridge_Uni alumni
Rockville. MD
Joined October 2019
RT @madamscientist: Pitt to pause PhD admissions, following Vanderbilt and USC, because of uncertainty of NIH funding to academic universit….
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Centromeres role in aging. Congratulations @sweta_sikder.
Exciting news! 🎉 After a long journey, my postdoctoral research is finally published! 🌟 While we often hear about telomere depletion with age, have you ever wondered what happens to our centromeres? 🤔 In this study, we show how centromeres weaken and ways to reactivate it !!.
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RT @tatsuofukagawa1: Our CENP-C paper is out. While we emphasized an importance of the CENP-T pathway, here we described how CENP-C pathway….
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Talk on CIN by the leader in the field David Pellman.
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RT @PeterLyLab: 🚨 Excited to share our latest paper in @CellCellPress identifying how under-replicated chromosomes in micronuclei become sh….
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We further showed that the CENP-A mislocalization in bTCP depleted cells was due to increased levels of.Mis18beta.
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In this paper we showed that depletion of bTRCP mislocalized endogenous CENP-A to non-centromeric regions and contributed to chromosome segregation defects.
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Here is our latest publication showing role of beta-TrCP in regulating Mis18 beta levels for preventing CENP-A mislocalization and chromosomal instability. @NCIResearchCtr.
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RT @gpsapkota: Targeted Dephosphorylation In Action!!.Two studies by @JinFengZhao1 and @kesslet345 from the @sapkota_mrcppu. Excellent coll….
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RT @GunjanM43894285: IIT Hyderabad is establishing a national facility for Single Molecule and Super Resolution Imaging. We are looking for….
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Validation of work by renowned scientists in the field motivates to move forward. Thank you @GAlmouzni for sharing your views on ours and work by other colleagues @NCIYaminiDalal @Foltz_Lab. @needfuzz @NCIResearchCtr .
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RT @gpsapkota: An excellent postdoctoral opportunity to join @sapkota_mrcppu to work on WNT signalling and colorectal cancer. We are lookin….
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a proteomics-based approach using immunoprecipitation coupled to label-free mass spectrometry (IP-MS) analysis revealed that loss of DNAJC9 promotes the association of CENP-A with H3–H4 nucleosome assembly pathways.
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We show that cells lacking DNAJC9 exhibit mislocalization of CENP-A throughout the genome, and induces chromosomal instability.
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We identified DNAJC9 and other regulators of CENP-A localization through the high throughput genome wide siRNA screen
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This was a multi institutional collaborative study between investigators from NCI, NCATS, Novo Nordisk Foundation, Frederick National Lab and University of Liverpool. @NCIResearchCtr, @ncats_nih_gov @novonordiskfond @BasraiMunira.
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