Rafik Tadros
@rafik_tadros
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Cardiologist-Electrophysiologist. Director, Cardiovascular Genetics Center @ICMtl. Canada Research Chair in cardiogenetics. Director of MD-research @UMontreal
Montreal, Canada
Joined July 2016
The @SCC_CCS Clinical Practice Update on Hypertrophic Cardiomyopathy (#HCM) is now online @CJCJournals and summarized in this Tweetorial https://t.co/3D9td64oaZ
@acrean_at_UOHI @Christian_S_73 @DrLaksman @seema_mital @RuelMarc1
@HeartsInRhythm @chfalliance @CanadianSADS 1/9
onlinecjc.ca
Numerous guidelines on the diagnosis and management of hypertrophic cardiomyopathy (HCM) have been published, by learned societies, over the past decade. Although helpful they are often long and less...
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Mutations in the HCN4 gene may be the cause of incessant and inappropriate sinus tachycardia #AHAJournals #Epeeps
https://t.co/XaKO7pBMnn
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1/5 Pleased to share a review in @NatureRevGenet on Clinical Use of Polygenic Risk Scores: Current Status, Barriers & Future Directions Discusses PRSs in the context of the ACCE framework (analytic validity, clinical validity, clinical utility & ELSI) https://t.co/BK52kjAX4Q
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Importance of repeated EP studies in DM1 patients. Our latest paper in @JAMACardio
https://t.co/bCynXnhWTa
jamanetwork.com
This cohort study investigates if the identification of patients with myotonic dystrophy type 1 who are at risk for major bradyarrhythmic events and eligible for prophylactic pacing should be based...
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💊 Flecainide for the Treatment of Andersen-Tawil Syndrome @JACCJournals #Cardiology #CardioEd #Epeeps #Genetics
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Our new data on subclinical PA and MACE is out in Circulation! For the first time, we show that renin-independant aldosterone production is associated with an increased risk of MACE independently of BP, in people mostly normotensive with low CV risk. https://t.co/d1yBjfUQkY
ahajournals.org
BACKGROUND: Primary aldosteronism (PA), an overt form of renin-independent aldosterone production, leads to a disproportionately high rate of major adverse cardiovascular events (MACEs). Mounting...
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🔥 Our Nature paper just dropped! We built EchoNext—an AI model that reads ECGs to detect hidden structural heart disease (SHD) 💡 🔬 Trained on 1.2M ECG-echo pairs 🏥 Validated across 6 health systems 📈 AUROC 0.85 👀 Outperforms cardiologists 🚨 Finds undiagnosed SHD in 73%
🧵1/Today, we published a key milestone towards AI based cardiac screening in Nature. https://t.co/Lr3ymIrgz5 EchoNext outperformed cardiologists and found thousands of high-risk patients missed in routine care. We also made a version available to the world.
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📢New Algorithm for Estimating LV Filling Pressure by Echo: 🔴increase in the number of patients in whom LV filling pressure can be estimated 🟢only 2 cases of indeterminate LV filling pressure and the majority had a definitive LV filling pattern https://t.co/4yL751yFFo
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The TaRGET trial has opened up four new sites across Canada! There are now active sites in Montreal, Quebec City, Scarborough, and Victoria. To learn more about the trial and active sites, visit: https://t.co/JZJewRGE9Y
#Cardiomyopathy #ACM #ARVC #ClinicalTrial
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Aujourd’hui est un grand jour! Publication, pour la première fois, des lignes directrices d’Hypertension Canada en français! Merci à la Société québécoise d’hypertension artérielle pour le soutien à la traduction du guide et de ses annexes! https://t.co/fdpitrnZL0
cmaj.ca
Contexte: Le Canada a longtemps figuré parmi les leaders mondiaux de la prise en charge de l’hypertension artérielle (HTA), mais ses taux de traitement et de maîtrise de l’HTA ont régressé ces...
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Gene-specific insights are transforming ARVC diagnosis, risk prediction & therapy. Precision medicine is here: https://t.co/my3AMMQOTx
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Detecting ARVC from ECG? A Canadian-led deep learning model shows high accuracy, paving the way for earlier diagnosis: https://t.co/siYU3McI5G
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Cardiomyopathy symptoms can be subtle, like fatigue, dizziness or shortness of breath but knowing the signs and your family history could make all the difference. 🧬 It is often genetic. 🫀 It can lead to heart failure or sudden cardiac death if undiagnosed. 🗣️ If you feel
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In this #JACCBTS review, Dr. @JolandavanderV4, et al provide an overview of genetic #cvHCM models, including main HCM hallmarks such as impaired relaxation, hypertrophy, fibrosis, myocardial or sarcomere disarray, & ventricular/cellular arrhythmias https://t.co/oLkOZJqV1z
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📣New from Nicastro et al! 📄Bi-allelic variants in POPDC2 cause an autosomal recessive syndrome presenting with cardiac conduction defects and hypertrophic #cardiomyopathy
https://t.co/aKppPsbQkj
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Just out 📢 in @AJHGNews 🧬 Bi-allelic variants in POPDC2 identified in 4 families with sinus node dysfunction, AV conduction defects, and hypertrophic cardiomyopathy. 🫀Mechanism? Impaired cAMP-dependent regulation of TREK-1 potassium channels, disrupting cardiac pacemaking &
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Bi-allelic variants in POPDC2 cause an autosomal recessive syndrome presenting with cardiac conduction defects and hypertrophic cardiomyopathy - ScienceDirect
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🚨 Very happy to share our last article just published in @ESC_Journals 🇨🇵 Nationwide prospective data on catheter ablations ⚡ in patients with congenital heart disease 🫀 A huge thank to all investigators! https://t.co/QayHnBCI4g
@APHP #EPeeps
academic.oup.com
AbstractBackground and Aims. Current evidence on catheter ablation for patients with congenital heart disease (CHD) is derived from small, retrospective st
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Outcomes in Patients with Cardiac Amyloidosis Undergoing Catheter Ablation for Atrial Arrhythmias.
heartrhythmopen.com
Cardiac amyloidosis (CA) is characterized by atrial myopathy, which predisposes patients to atrial fibrillation (AF) and other atrial arrhythmias (AA). Although catheter ablation of AA is effective...
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Can Heart Rate Fragmentation predict AF in the general population aged 65+? 🔍 Risk stratification based on Heart Rate Variability enables smarter AF screening. 📷 https://t.co/3Ab6yYYJyr
@DrFuSiongNg @ivroca @aportasanchez @LluisMont2
#AFib #EPeeps #CardioTwitter
academic.oup.com
AbstractAims. Screening the general population aged 65 for atrial fibrillation (AF) has been proposed as a preventive measure against potential complicatio
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