Pete Hendrickson
@pghendrickson
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Radiation oncologist @DukeRadOnc| DUX factors, embryonic genome activation, and cancer
Durham, NC
Joined May 2015
RT @DKirschMDPhD: Just in time for #CTOS2024: Thrilled to share SU2C-SARC032 (NCT03092323), a randomized trial of pembrolizumab in Stage 3….
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RT @SU2C: Your donation dollars in action! 🙌A #StandUpToCancer-funded #research team unveiled an exciting #clinicaltrial breakthrough that….
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Huge thanks to @ConquerCancerFd and @quadwfoundation for giving me this opportunity and for funding sarcoma research. Elated to join the growing network of QuadW researchers both near and far.
Congratulations to this year's class of Conquer Cancer Grant and Award recipients! We can't wait to celebrate with you at #ASCO24! Full list of recipients:
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RT @ControllingLMNT: Excited to share our work on chromatin landscape remodeling in cloned embryos! 🐄🐄We started off w/ simple question: ho….
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RT @thekevintu: (1/5) Our paper on pooled genetic screening of TERT-mutated #glioblastoma is out in @NaturePortfolio @oncogenejournal! We a….
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Most importantly, we learned that CDS (unlike Ewing sarcoma) can probably be modeled in mice, however, innovative approaches to prevent spontaneous recombination will be required. Stay tuned!.
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So what did we learn? Well, for starters, CIC-DUX4 is a very potent oncogene which seems to behave as a neomorphic transcriptional activator in line with prior findings.
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As it turns out, the problem wasn’t just leaky expression of the inserted fusion gene but spontaneous loxP recombination; a rare event in Cre-LoxP models that normally goes unnoticed.
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Sort of. Unfortunately, all of the tumors developed in our chimeric animals which had never been exposed to Cre recombinase. Worse yet, the burden of disease was so extensive that nearly all of the animals died before breeding age.
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Amazingly, all of the mice developed aggressive small round cell tumors which grew rapidly and metastasized early mimicking the disease course (and the appearance) of human CDS. So that’s good, right?
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We set out to make a genetically engineered mouse model of CDS using a somewhat conventional Cre-LoxP approach. One model tuned into three models but not for the reason you think…
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CIC-DUX4 fusion-gene driven sarcoma (CDS) is a devastating cancer that primarily affects kids and young adults. Because of its rarity, primary tissues are scarce and clinical trials are not feasible. Can we use mice instead? A thread….
Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse models #biorxiv_cancer.
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RT @ACKoongMDPhD: Physician-scientists are a dying breed going from 4.7% in '80s to ~1.5% today. Multiple factors contribute including fla….
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RT @ControllingLMNT: In SLC for Brad Cairns’ 25th lab anniversary. Was truly a humbling experience to be a part of great science with great….
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Thanks @HenningWillers for an energizing finish to a great night @DukeRadOnc research retreat
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So humbled and honored to receive this award. Thank you @ASTRO_org for recognizing our work and supporting my physician-scientist aspirations.
Pete Hendrickson, MD, PhD, has been selected to receive the 2022 @ASTRO_org Residents/Fellows in #RadOnc Seed Grant for his project "Ewing-like Sarcoma: Targeting the CIC-DUX4 oncogene through epigenetic regulators." @pghendrickson is mentored by @DKirschMDPhD – congrats to both!
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RT @ZhiyuanChen12: Very impressive work! What compensates Dux in mouse ZGA has puzzled me for ~4 years. I generated Obox1/2/5/7 QKO, but fa….
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Thanks @DukeRadOnc and @DKirschMDPhD for the incredible support and confidence. The environment @DukeHealth is optimal for physician-scientist trainees.
Congrats to @pghendrickson (RORS, NCI R38 scholar) and PI @DKirschMDPhD for their recently awarded DOD grant to investigate models, mechanisms and tx for CIC-DUX4 sarcoma; an extension of Dr. Hendrickson's PhD work that defined the role for DUX4 in embryonic development #RadOnc
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RT @biorxiv_genomic: Competition for H2A.Z between genes and repetitive elements establishes response to anti-viral immune activation http….
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