Pedro Schwartzmann, MD, PhD, FESC 🇧🇷
            
            @pedschwartzmann
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              MD, PhD, father, Cardiologist #HeartFailure, Cardiac intensive care, Cardiomyopathies, Cardio-Onco, Cardiopulmonary Exercise Testing, Cardiac Rehab #GBCObrazil
              
              Ribeirão Preto, State of São Paulo, Brazil
            
            
              
              Joined April 2018
            
            
           Among hypertensive patients with high cardiovascular risk, lowering systolic blood pressure with a target of <120 mm Hg compared with <140 mm Hg has a favorable impact on retinal microvasculature.  https://t.co/LFNfJXzFjh 
            #GWICC #AHS2025 #ACCIntl #JACC #Hypertension
          
          
                
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             Currently live at #eSPACEHF2025! Plenary Session 4 – Managing Cardiomyopathy in Heart Failure is underway. Prof. Giuseppe Rosano and Dr. Pedro Schwartzmann, MD PhD opened with key clinical approaches to cardiomyopathies in HF. Prof. Maurizio Pieroni finished presenting on 
          
                
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             Session 4 Wrap-Up – Managing Cardiomyopathy in Heart Failure We just concluded Session 4 of #eSPACEHF2025, chaired by Prof. Giuseppe Rosano and Dr. Pedro Schwartzmann, focusing on the complexities of cardiomyopathies in HF. Prof. Maurizio Pieroni opened with Heart Failure in 
          
                
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             β-blockers safe pre-discharge in #HFrEF
            #COPERNICUS ☠️ benefit in recent decomp  https://t.co/RPAODKmbNj 
            #STRONGHF rapid uptritration ⬇️ events  https://t.co/2EGk0obyDg 
            #IMPACTHF ⬆️ Rx persistence  https://t.co/pc0wJkfY7U 
            #BCONVINCED stopping not helpful  https://t.co/GdMoEu5qr8 
          
           Heart failure colleagues. I would propose a new focus of emphasis Re the acute Rx of newly decompensated systolic failure. We should favor afterload reduction FIRST. Seminal Beta-blocker trials were in ambulatory outpts. Giving BB to decompensated failure is a mistake. IMO. 
          
                
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             🔥 New in @NatureMedicine How do you communicate lifetime benefits expected with HFpEF therapies? New data from 3 RCTs (#DELIVER #FINEARTS #PARAGON) estimate up to *5 years* of event-free survival w combination Rx #GDMT for HFpEF has finally arrived! 🔗  https://t.co/ozSx3UwkLN 
          
          
                
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             Transthyretin amyloid cardiomyopathy: from cause to novel treatments. Read this State-of-the-Art review just published in #EHJ 👉  https://t.co/xs8gK2WEW0 
            @RoccoMontone @ehj_ed #amyloidosis
          
          
                
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             Artificial Intelligence–Enabled Quantitative Coronary Plaque and Hemodynamic Analysis for Predicting Acute Coronary Syndrome AI-enabled plaque and hemodynamic quantification enhanced the predictability for ACS culprit lesions over the conventional coronary CTA analysis. 
          
                
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             New therapeutic targets in heart failure: the role of RNA-binding proteins: read the news in #EHJ! #heart #failure #therapy #EHJ #cardiotwitter @ESC_jorunals @escardio
             https://t.co/AL6qA93ZEV 
          
          
                
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             Albuminuria in Cardiovascular, Kidney, and Metabolic Disorders: A State-of-the-Art Review Urinary albumin-to-creatinine ratio is an attractive, unifying biomarker of cardiovascular, kidney, and metabolic conditions that may be useful for identifying and monitoring disease 
          
                
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             Exercise Training in Heart Failure: Clinical Benefits and Mechanisms  https://t.co/JGOzKPJY4n 
          
          
                
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             Strengthening the Case for Earlier LDL-C Lowering 1️⃣ Even with CAC = 0, higher LDL-C was linked to more non-calcified plaque and greater CHD risk. 2️⃣ Each 1 mmol/L (≈38.7 mg/dL) higher LDL-C raised the risk of MI by 26% and CHD events by 28%. 3️⃣ Findings reinforce the 
          
                
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             High blood pressure is the most prevalent and modifiable risk factor for the development of cardiovascular diseases, including coronary artery disease, heart failure, atrial fibrillation, stroke, dementia, chronic kidney disease, and all-cause mortality. This reflects several 
          
                
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             🎯 Precision Lipidology Enters the RNA Era Small interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs) are reshaping lipid management by targeting mRNA degradation at the source. 👉Inclisiran targets PCSK9 → ↓LDL-C 👉Volanesorsen, Olezarsen, Plozasiran target 
          
                
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             Aldosterone and Aldosterone Modulation in Cardio-Kidney Diseases Partial agonists of the MR and directly attenuating aldosterone production using selective aldosterone synthase inhibitors is an emerging approach for patients with HF, CKD, and uncontrolled and resistant arterial 
          
                
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             Wow, the game has changed! #SURPASSCVOT meets its primary & secondary endpoints in first *head-to-head* CV outcomes trial! Tirzepatide (dual GLP1/GIP agonist) vs Dulaglutide (GLP-1RA) including 16% lower risk of all cause mortality!  https://t.co/rUFYZVn41N 
          
          
                
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             🩺 Every hypertrophic wall has a story 💭🤔 ECG, echo, CMR & genetics can reveal: – HCM – Amyloidosis – Fabry – Mitochondrial or syndromic disease Red flags 🚩guide precision treatment. #Cardiology #HypertrophicCardiomyopathy #MedTwitter #StateOfTheArt
          
          
                
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             💊💥 New trial, new strategy: Dapagliflozin + spironolactone packs a bigger biomarker punch in #HFpEF. But what’s the trade-off? Kidney function takes a hit. The SOGALDI-PEF trial stirs up the combo therapy debate.  https://t.co/t7wF6f07ii 
            #HeartFailure #SGLT2i #NTproBNP #JACC
          
          
                
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             Primary Left Atrial Cardiopathy in Transthyretin Amyloidosis Cardiomyopathy by Multimodality Imaging: Implications for Thrombotic Events Primary LA cardiopathy seems to be associated with TEs in ATTR-CM, independently of AF, CHA2DS2-VASc, and LA dilatation, unlike other LVH 
          
                
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