And that’s a wrap! 🎉 The INEM 10-YR Anniversary Symposium was filled with inspiring talks, dynamic Flash Talks by young researchers, and engaging discussions. Thank you to everyone who joined us to celebrate science and collaboration! #INEM10YEARS #INEM2024

[PUBLICATION] New study with the Bharat lab @CellBiol_MRCLMB reveals the structure of the Neisseria meningitidis filamentous phage MDAΦ. Cryo-EM/ET show how phage bundling supports biofilm formation & pathogenesis. @MathieuCoureuil @PNASNews.

[PUBLICATION] PIK3CA mutations in Schwann cells trigger neuropathy by disrupting nearby healthy tissues. This non-cell autonomous effect shifts local metabolism toward aerobic glycolysis. Early alpelisib treatment is key | @PNASNews .🔗@CanaudLab

@ScienceMagazine @pontoglio_marco @FabiolaTerzi @IsnardPierre1 @Nico_BioloGeek @CanaudLab @turinsky47926 @NKuperwasser @MRabant @SfrNecker The study highlights how YAP hyperactivation in podocytes reprograms cell fate and triggers PEC proliferation, revealing CTGF and HB-EGF as key mediators, and therapeutic targets, in crescentic glomerulonephritis.

[PUBLICATION] Podocyte-specific YAP activation drives crescentic glomerulonephritis via cross-talk with parietal epithelial cells. 🌙.A study from the Terzi & Pontoglio labs now out in Science Translational Medicine @ScienceMagazine.

🗓️ Join us on July 4, for a #seminar with David Sabatini, group leader at @IOCBPrague. Dr. Sabatini will explore nutrient sensing by the mTOR pathway. Don’t miss it! @MarioPende

[PUBLICATION] mTORC1 governs multiciliated cell differentiation by favoring progression through a cell cycle variant without DNA replication and by acting on cytolinker proteins for centriole disjunction. 📖Read more: @MarioPende

[PUBLICATION] First report of successful pregnancies after treatment with alpelisib for PIK3CA-related overgrowth spectrum. ➡️Fertility preserved.➡️No embryotoxicity.➡️Disease remained responsive after treatment pause. 📖Details here:

🗓️ Join us on June 20, for a #seminar with Jean-Emmanuel Sarry @jeansarry, team leader at @crctoncopole. Dr. Sarry will explore Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia. Don’t miss it!

🚨 We're hiring at INEM!. The Immunity in Health and Disease team, led by @FillatreauSimon, is recruiting:. 🔬 Assistant Engineer.🧑‍💼 Horizon Europe Project Manager (ARTiDe project). More info & how to apply: . 🔗 🔗 @Inserm.

🗓️ Join us on June 13, for a #seminar with Han Li, Principal Investigator and leader of the cellular plasticity in age-related pathologies group at Institut Pasteur. Prof. Li will explore senescence induced-cellular plasticity in health & disease. Don’t miss it! @MarioPende

🗓️ Join us on Friday, June 6, for a #seminar with Elvira Mass, Head of the Department of Developmental Biology of the Immune System at @LIMES_Bonn. Prof. Mass will explore the developmental programming of tissue-resident macrophages. Don’t miss it!.@VenteclefNicol1 @ImmediabL

🚨 We're hiring! The @ImmediabL team is looking for:.🧪 1 Postdoc.🧬 1 Research Assistant / Bioinfo/ Tech.📍 Paris | Start Sept 2025.📄 Full details + apply: @DrFAlzaid

[PUBLICATION] Treating patients with somatic PIK3R1 mutations using alpelisib leads to clinical and radiological improvement. A promising step toward targeted therapy in PIK3R1-related disorders. 📄Read more: @CanaudLab @morin_gbrl @EmboMolMed

🗓️ Join us on Friday, May 16, for a #seminar with Chantal Desdouets, Head of the "Genomic Instability, Metabolism, Immunity and Liver Tumorigenesis" team at Centre de Recherche des Cordeliers. Dr. Desdouets will explore Polyploidy in chronic liver diseases. Don’t miss it!

🗓️ Join us for a special #seminar with Bing Su, Director of the Shanghai Institute of Immunology & Chair at Shanghai JiaoTong University School of Medicine. Prof. Su will explore Sin1-mTOR signaling in immune cell metabolism, growth & survival. Don't miss it! @ImmediabL @sjtu1896

🗓️ Join us on Monday, Apr 28, for a #seminar with Christopher Goodnow, Head of the Immunogenomics Lab at @GarvanInstitute. Prof. Goodnow will explore how B cell tolerance breaks and resists rituximab treatment. Don’t miss it!

🗓️ Join us on Friday, Apr 25, for a #seminar with Brendan Manning, Professor and Chair in the Department of Molecular Metabolism at the Harvard T.H. Chan School of Public Health. Prof. Manning will exlpore the TSC-mTOR pathway in growth and metabolism. Don’t miss it!

🚨 Postdoc Opportunity.Join the "Host-Pathogen Integrative Biology" team at INEM to study endothelial microparticles in cardiovascular dysfunctions during bacterial sepsis. 🌐More info & application: @MathieuCoureuil

🗓️ Join us on Friday, April 11, for a #seminar with Prof. Philippe Sansonetti (@institutpasteur) on Gut dysbiosis and colorectal cancer. Don’t miss this talk diving into how microbial imbalances shape cancer development — and how we move from observation to mechanistic insight.

🏆 Congrats to @JulianeDaGraca! Former PhD student at INEM, Juliane has been awarded the 2025 Thesis Prize of the Club Exocytose-Endocytose for her work on ER-endosome contact sites & autophagy regulation. 👏 Well done, Juliane! @MEMBRAMICS_lab