Niño Posadas
@ndposadas
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Interested in host-microbe interactions and gene regulation | PhD student @CCB_Galway, Prev @mmbl_upmsi
Philippines
Joined April 2012
Happy to share our new paper on calcareous sponge stress response, finally out in @Ecol_Evol! Here we found that L. chagosensis activates both the adaptive and proapoptotic phases of the unfolded protein response (UPR) under thermo-acidic stress. https://t.co/aEZBBXk604
onlinelibrary.wiley.com
This study describes the gene regulatory networks that govern the stress response of a calcareous sponge under future ocean scenarios. We discovered that the sponge activates both adaptive and...
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✨Animal evolution fans, rejoice! CRISPR-Cas9 is now in Corallochytrium (Teretosporea, which includes Ichthyosporea), ready to unlock secrets of animal origins! 🔬Led by @PSuarezAra & Sebas Najle. https://t.co/SBIHZfGonq
@royalsociety #animalorigins #holozoans #protists
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I am looking for a new postdoc to join the lab. Interested in pluripotency, germ cells, and in investigating these in a genetically tractable cnidarian? Get in touch! We offer a long-term contract, excellent research environment, and a lovely city #Galway. https://t.co/2hLNLGNGxe
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Happy to have contributed to this celebration of my favourite protein CENP-A in Chromosome Research: https://t.co/5XlLWPSJav
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New Publication. Increasing evidence suggests that larval neuroendocrine signaling plays an important role in the settlement and metamorphosis of marine invertebrates. In this study, Keana and colleagues explored how neurotransmitters influence these processes in giant clams.
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My group is hiring a new Postdoc to work on gene regulation and chromatin in Nematostella. Please RT! For more information see here: https://t.co/vHA6sDoEMm
https://t.co/6gxsBDkYFh
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Very happy to have been awarded this grant along with 3 (yes 3) of my @CCB_Galway colleagues. This grant will allow me to start working on Nematostella again and I am actively looking for PhD students and Postdocs.
Amazing to see 4/5 @Researchirel Frontiers for the Future awards announced today for @uniofgalway coming to PIs in the CCB! Congratulations to all! @Galway_Research
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Elated to share our newly published paper that describes the potential link between prokaryotic microbiome dynamics and coral heat tolerance 🪸💪🏻🦠🔥 Yezz @jbquij 🍻 https://t.co/DrIzSeOV7G
enviromicro-journals.onlinelibrary.wiley.com
This study describes the link between thermotolerance and prokaryotic microbiome dynamics in the coral, Acropora cf. tenuis. At ambient temperature, coral colonies host similar microbial communitie...
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Fascinating work by @ColgrenJeffrey & @Pawel_Burkhardt reveals electrical signaling and coordinated behavior in #choanoflagellate colonies 🤩 Out now and featured on the cover of @ScienceAdvances 👏
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New in @ScienceAdvances @CurantzC et al. find that part of the #Hydractinia gonad acts a sexual organizer; it induces germ fate in pluripotent i-cells. Germ cells secrete the TGF-beta Gonadless to induce and maintain the gonad https://t.co/0wqEjksGlF
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Our work on coral stress response is finally out in @thePeerJ. We highlight how expansion and high constitutive expression of stress response genes contribute to ecological success of thermotolerant species.
Dive into this study here: https://t.co/B9YLXqD2lo
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SOX and POU are crucial Transcription Factors in animal development, believed to be innovations. We found them in unicellular relatives of animals. And hold tight, you can use a choanoflagellate 🦠 SOX gene to make a full chimeric 🐁 ! Read more here: https://t.co/oCmQjV3WIB 1/6
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Happy to share that the Gahan lab will be branching out (or more like returning) to working on Nematostella in the near future. Details will follow but for now if anyone is interested in doing a Postdoc or PhD in 2025 on chromatin in Nematostella drop me a message :)
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Today in @natchembio we share a new strategy to design fully synthetic “artificial” bZIP family transcription factors that directly block DNA binding of HIF1a and XBP1 to inhibit hypoxia-dependent oncogenic signaling in cells and in vivo. 1/n https://t.co/1xIyfjbw0O
nature.com
Nature Chemical Biology - Qiao and Nguyen et al. describe a strategy to block hypoxia-dependent gene expression in cell and mouse models of breast cancer through dual targeting of X-box-binding...
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How will marine life adapt to climate change? Duplication of genes and diversification of functions might be one strategy. Link to full paper: https://t.co/ntoqhMpOfg Photo courtesy of Niño Posadas
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Check out our new preprint on coral stress response!
Interspecies differences in the transcriptome response of corals to acute heat stress https://t.co/QZCIjNvcPd
#biorxiv_genomic
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🧵1/6 The second paper of my PhD is out now! Advanced access article here: https://t.co/Einx6WEP5H I’ll also be presenting these results at the ISME19 in Cape Town this week @MarineMicrobio @MolEcol_MPIMM
academic.oup.com
Abstract. Heterotrophic microbes are central to organic matter degradation and transformation in marine sediments. Currently, most investigations of benthi
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In investigating the unique body wall of the sea cucumber Stichopus cf. horrens or hanginan, scientists found potential for a new kind of smart bio-material. Link to full paper: https://t.co/oPOAEDWqzy Photo courtesy of Kim Sisican
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So its out @GenomeBiology: https://t.co/OIzQ8veSgW. All you need to know about DNA methylation in annelids🪱! This has been a great collaboration with the @Chema_MD lab, led by @k_guynes. One of the main findings is that the methylome erodes throughout development and beyond! 1/
genomebiology.biomedcentral.com
Background DNA methylation in the form of 5-methylcytosine (5mC) is the most abundant base modification in animals. However, 5mC levels vary widely across taxa. While vertebrate genomes are hyperme...
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Really happy that my PhD work done in Hiroshi Watanabe lab @OISTedu is finally out. Neuronal and non-neuronal functions of the synaptic cell adhesion molecule neurexin in Nematostella vectensis.
nature.com
Nature Communications - The evolutionary origin of neural synapses is unclear. Analysis of cnidarian neurexins provides clues as to when this synaptic hub molecule, which had an ancestral role in...
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It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇 https://t.co/I2j2pAel69
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