Nathan Skene
@n_skene
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Neurogenomics lab @UKDRI at Imperial College. Integrating single-cell data with GWAS to gain insight into brain function and disease
London
Joined June 2009
Want to know which cell types underlie complex brain traits, including PD, Schiz, Alzh and BMI? We wanted to know the answer and that has lead to our latest preprint ( in a fun collaboration between myself, @JulienBryois, Pat Sullivan and @HjerlingLeffler.
biorxiv.org
Genome-wide association studies (GWAS) have discovered hundreds of loci associated with complex brain disorders, and provide the best current insights into the etiology of these idiopathic traits....
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RT @joe_pickrell: New blog post! . The implications of large sequencing studies have only partially registered in academia, and not at all….
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RT @Quillette: Since 2023, Gaza has been at the centre of repeated famine claims. Harrowing images circulate daily, and advocacy groups spe….
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RT @joe_pickrell: New project! . There's now a steady stream of discoveries of rare, high-impact genetic variants coming from resources lik….
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RT @anshulkundaje: Job Alert: A stealth startup focused on non-cancer diagnostics is keen to hire a deep learning for genomics/bio engineer….
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RT @LukasHeumos: I hate reference limits of journals so much. I'm sitting here trying to find a few more references to remove despite me kn….
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RT @thenormanlab: Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq….
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RT @NikoMcCarty: A new machine learning tool, ProDomino, can predict where two proteins are able to be “fused” together. This seems really….
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RT @eric_is_weird: "BBNs" have officially been given a government name: Frontier Research Contractors. The reason why: @ARIA_research has f….
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RT @IdoAmitLab: Stimulating perspective on neutrophil heterogeneity and function. A must-read from #ThePowerOfMany.
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RT @BernoulliDefect: Running back calculations on this, the one off stock gift to ARM employees would now have been worth $22B. Blocking th….
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RT @alysdenby: The City Bridge Foundation is an ancient fund with deep pockets whose specific purpose is to build and maintain London’s bri….
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RT @BellaWallerstei: Today the British government sent a clear message: massacre innocent civilians and get rewarded. Recognising Palestine….
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RT @anshulkundaje: Thanks to @riyavsinha in my lab, @igvteam browser will natively support dynseq (dynamic sequence tracks) in an upcoming….
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RT @MariosGeorgakis: Enriching polygenic risk scores with single-cell ATAC-seq about chromatin accessibility in disease-relevant cell types….
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RT @MariosGeorgakis: Probably the most promising use of proteomics in drug development is creating signatures that act as surrogates for ha….
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RT @drklly: I'm excited to share work on a research direction my team has been advancing: connecting machine learning derived genetic varia….
biorxiv.org
Genome-wide association studies (GWAS) have identified thousands of trait-associated loci. Prioritizing causal variants within these loci is critical for characterizing trait biology. Statistical...
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RT @MariosGeorgakis: While UK Biobank enabled access to population-based proteomics at scale, most omics studies in disease-focused cohorts….
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RT @anshulkundaje: IMO, medium scale combinatorial regulator perturb expts with diverse measurable stoichiometry are going to be far more i….
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RT @segal_eran: Excited to share a milestone published in @NatureMedicine from our decade-long effort to build The Human Phenotype Project,….
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