Anand Muthusamy
@mu_anand
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Science & Adventure. Research Fellow @Convergent_FROs. Prev: PhD @Caltech protein eng + neuro; chem bio @Penn, @HHMIJanelia; biotech VC.
Los Angeles, CA
Joined April 2015
We spend so much time behind computer screens that we forget that things feel different in person. Rothkos are supposed to fill your visual field. Think marine sunsets. Or why 2001: A Space Odyssey was supposed to be seen on Cinerama screens.
paul graham sees stuff like this and unironically believes it makes rational sense to pay more than like, $20 for it
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RT @eric_is_weird: "BBNs" have officially been given a government name: Frontier Research Contractors. The reason why: @ARIA_research has f….
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Discussion blurb:."Here, we demonstrate conclusively that although LD abundance in neurons is very low at steady state, in agreement with most previous literature observations, this is the result of a constant flux of FAs through the LD pathway.
nature.com
Nature Metabolism - Kumar et al. show that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function.
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100-year dogma says neurons don't use fat as fuel. ChatGPT and I would have agreed. Tim Ryan's lab says otherwise now! Good case for why we should study intact living systems, especially in the brain.
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Back then we had a prof in a freshman course ask us to estimate the amount of trace phosphorus to expect in their buffers. There was potentially enough there for the bugs to survive without incorporating arsenic. Good lesson in sanity checks.
Science finally retracts the Arsenic life paper
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RT @CorreaDan: Congrats @AdamMarblestone - federal policy is catching up!. The FRO model is well suited to a world of AI-accelerated scienc….
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Incredible ROI: "For the past several years, CASP has gotten around $639,000 from the National Institute of General Medical Sciences at the NIH, which supports two full-time employees. They coordinate the biennial international conference/competition. "
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Great review giving the nuts and bolts of wearable ultrasound devices. Appreciate the physical intuitions w/ numbers to back and grounded view of a ton of clinical apps. Congrats @XugroupUCSD and team!.
This article in @natrevbioeng offers a comprehensive overview of recent advances in wearable ultrasound technology across academia and industry. We did our best to cover the full landscape and are deeply grateful to the researchers whose work we reviewed. In the final section, we.
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But then how do we explain arthritis pain drug drip
Biotech is not considered cool.
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Yeah. the Rick Rubin posting is telling. The antidote to specialist FOMO is knowing that mastering one thing requires understanding many things. Anyway, here is the Angeles Forest at sunset yesterday.
I worry the pendulum has swung too far towards generalists over specialists, sacrificing wisdom for speed. Resulting in either boring consensus or unserious hype. There is such a thing as deep technical craft, but I’m not sure you can understand if you’ve never done it yourself.
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Engineer mindset W."It is the optimization of the whole system (drug, drug formulation and device) that is necessary for the successful development of inhalation therapies, both new and old. ".
Honestly, I don't think any VC predicted so many $Billions of equity value creation from nebulizers. $VRNA $INSM. Feels to be a VC should be investing in hand-held battery powered nebulizers.
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Very excited to see these tools come online! Hormones likely have a lot of interesting subcellular dynamics just waiting to be uncovered. cpGFP is just the gift that keeps on giving.
(1/3) Excited to introduce our new GRAB sensors for a series of steroid hormones! These tools enable real-time detection of steroid hormone dynamics in vivo🐭🧠.Happy to share these sensors and welcome any feedback!Please contact yulonglilab2018@gmail.com for information.
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Definitely underrated. Acknowledgments for the people map; chapter 1 for the concept map.
the more i read phd dissertations, the more i'm convinced they're often the best way to grok a given subject. maybe bc the author is a student and just went through the exp of learning the stuff fresh in their mind? derivations easy to follow, explanations intuitive, etc.
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"When next you hear 'More is better', just remember that Uncle Syd says 'The least is best.'" 🤌.
@StearnsLab @jboysen0 Relevant one: Sillycon Valley Fever.
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RT @srikosuri: OK. I posted a first attempt at spelling out some of my thoughts on the new race for virtual cell models. Overall, I'm excit….
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