Mike Mitchell
@MJMitchell_Lab
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Associate Professor of Bioengineering | Lipid Nanoparticles | mRNA Therapeutics & Vaccines | Drug Delivery | Biomaterials | Immunotherapy
Philadelphia, PA
Joined August 2011
Thrilled to share our latest in Nature Biomedical Engineering @natBME led by @MJMitchell_Lab Postdocs Ningqiang Gong @DongyoonKim5 on a Mannich reaction approach to create antioxidant lipid nanoparticles for safer and effective mRNA therapy! Free access: https://t.co/P5R9PEKz8F
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🎉 Huge congratulations to Dr. Jennifer Patten on passing her PhD defense! Jennifer holds the distinction of being the first PhD graduate from our lab, and she's on the market for Assistant Teaching Professor positions. Institutions looking for an exceptional one should reach out
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Unlock Asia's green growth opportunities and drive decarbonisation strategies from SG.
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Check out our latest collaborative work in @Biomaterials_ with @KaraSpillerLab @HannahGeisler_ @WeissmanLab on a new interleukin-4 mRNA lipid nanoparticle macrophage cell therapy to sustain a pro-reparative phenotype in inflammatory injuries! Open access: https://t.co/XeUJ3wX8yx
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Check out our latest news and views article in Nature Nanotechnology @NatureNano led by @MJMitchell_Lab Postdoc Zhangyi Luo on @BowenLi_Lab's modular mRNA LNP platform for programmable induction of tumor-specific immunogenic cell death! Free access: https://t.co/THqbqkpZOS
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Super exited to share our latest review in Cell Biomaterials @CellBiomat led by my PhD student Nei Li in collaboration with Profs. Ying Xu and Yinghui Wei on summarizing tools and delivery technologies for mitochondrial gene editing! Free access: https://t.co/DEhz5BvbCk
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The 2025 Limited First Edition Unity Bag has sold out within one week of launch. We are humbled and moved by the overwhelming response and love we have received. The Unity Bag was created as a quiet tribute to Fostering the Future and as a message of hope. It is the greatest
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Check out our latest in @BioconjChem led by Hannah "Coach" Safford @hannahsafford_ on emerging nucleic acid cargos for next-generation RNA vaccines and therapeutics! Lookout for exciting saRNA and circRNA LNP projects from @MJMitchell_Lab this year! Link: https://t.co/AOm61ZfZXV
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A huge thanks to @CHADNANO @DrMTeplensky for including us as part of this exciting PNAS special issue on structural immunotherapy:
pnas.org
The Structural Immunotherapy: Breakthroughs in Vaccine Development Fueled by Nanotechnology Special Feature highlights how nanoscience is revolutionizing vaccine design through structural immunothe...
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Excited to share our latest in PNAS @PNASNews led by @MJMitchell_Lab Postdocs @JinjinWang40973 @ShiQiangqiang on a drug loaded bispecific T cell nanoengager platform to overcome T cell exhaustion for potent cancer immunotherapy! Open access: https://t.co/8zRIGJ91PB
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Celebrate gaming’s biggest night with epic deals on award‑winning titles!
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This integrative approach represents a notable advance in LNP characterization, offering a more mechanistic understanding of how structural and biophysical attributes influence functional performance. - Another fantastic work by @MJMitchell_Lab and his team! @NatureBiotech
Research Briefing: Solution biophysics reveals the polydisperse structure of RNA lipid nanoparticles https://t.co/BpyiKnNvxF
https://t.co/c8RiMnLVG3
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Huge shout out to @WeiTaoLab for the kind words about our study!
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Check out our latest research briefing in @NatureBiotech led by @MJMitchell_Lab Postdoc Marshall Padilla showing how solution biophysics can reveal the polydisperse structure of RNA lipid nanoparticles! Briefing: https://t.co/3xbhbSdw5x Original Article: https://t.co/8enEoQW7t4
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Had a blast at our inaugural @Dan_A_Heller @MJMitchell_Lab joint lab apple picking event @TerhuneOrchards! Great team bonding and collaboration building. We look forward to making it an annual tradition!
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Insights Into Lipid Nanoparticle Structures Could Pave the Way to More Targeted Therapeutics Findings reveal that #LNPs come in a surprising variety of configurations. The differences correlate with their delivery capabilities @GuptaPenn @MJMitchell_Lab
https://t.co/o3Cy0RT0V0
genengnews.com
The findings reveal that LNPs come in a surprising variety of configurations and the differences correlate with their delivery capabilities.
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Elucidating lipid nanoparticle properties and structure through biophysical analyses https://t.co/TVq9PT9ja0
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Marshall is currently on the faculty job market, scoop him up while you can!
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Thrilled to share our latest in @NatureBiotech led by @MJMitchell_Lab Postdoc Marshall Padilla in collaboration w @GuptaPenn on elucidating mRNA lipid nanoparticle structure through biophysical analyses! LNPs can have crazy shapes, see below: Free access: https://t.co/Idkn6t7FZO
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A surprise bonus from COVID-19 vaccines: bolstering cancer treatment | Science | AAAS
science.org
Patients who got shots of mRNA before starting a type of cancer immunotherapy lived much longer
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Check out our latest in Nanoscale Horizons co-led by @MJMitchell_Lab Postdocs and PhD students Melgious Ang, Ann Metzloff, and @ASThatte2 on lipid nanoparticles for engineering next generation CAR T cell immunotherapy! https://t.co/6LKSYH66k3
pubs.rsc.org
Lipid nanoparticles are a burgeoning technology which has vast potential to improve chimeric antigen receptor (CAR) T cell immunotherapy. This focused review provides an overview of CAR T cell...
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Excited to give a talk at the @ALSTDI Summit on our work on systemic mRNA lipid nanoparticle delivery to the brain! Great opening address by CEO Fernando Vieira!
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The day wraps up with a panel discussion featuring all our symposium speakers reflecting on the future of nanoscience and where discovery goes next. #Nanoscience #IIN #Northwestern
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