What a year 2022 has been so far for the Mistriotis Lab @AuburnEngineers! Our lab has received the @NIGMS R35 MIRA ESI grant and the Career Development Award from the @AHAScience resulting in a total amount of $2.1M. 🧵

🎉 Excited to share that the Konstantopoulos Lab will be presenting our latest work at #BMES2025! Come check out our talks, spanning mechanobiology, cancer invasion, and bioengineering innovation. 🧠🔬 See details below 👇

Hope you’ll join us on Friday at 8:30 AM (room 28B) for this special session on #Mechanobiology and #Mechanomedicine! Looking forward to learning a lot while generating new ideas and collaborations! @BMESociety

Congratulations to the 2025 Young Innovators! Come see their talks on Friday, October 10 at #BMES2025. Apply to become a Young Innovator next year!

We have developed a new workflow to map whole human organs at single-cell resolution, while integrating spatial transcriptomics, proteomics, and metabolomics. We applied this workflow to map precancerous lesions of the fallopian tubes. More here: https://t.co/UoTgbRK93s

In our new paper, we produced a 3D single-cell reference map to guide the design and validation of a new multi-compartment assembloid that mimics the function and architecture of the human endometrial tissue, exhibiting stromal decidualization. More here: https://t.co/ABJrYxgVw2

Please spread the word about this foundation dedicated to dilated cardiomyopathy caused by mutations in the LMNA gene. It helps connect patients and provide them with resources and connections to clinicians and researchers.

To all our collaborators, Drs Stoletov, Lewis, Friedl, Gu, @GerechtLab, Martin and Wu: thank you for your support and contributions!

🎉After years in the making… our work, @KKLabJHU @AveryTTran, Dr Wisniewski & Dr Kalab, is out in Nature Materials! Anillin & Ect2, best known for their roles in cell division, are repurposed by cancer cells to drive confined migration and extravasation.

Check out our lab's latest review by @MFarisHazwan @MBIsg @BME_NUS in Current Opinion in Cell Biology @sciencedirect 🔗 https://t.co/e7UJmw6G3G We teamed up w/Brian Aguado @ucsdbe to highlight region- & sex-specificity of #ECM signaling in the aging heart!🫀 Hope you enjoy!

Thrilled that our newest work led by @AveryTTran, Dr. Wisniewski, and @mistrigr is out today in @NatureMaterials! We show how the cytokinesis proteins Anillin and Ect2 drive RhoA/ROCK/myosin-mediated invasion in confining spaces in vitro and in vivo. https://t.co/HXCOZmcXKv.

I'm pleased to announce that CMBE now has an impact factor of 5.0! And don't forget, there is no publishing fee.

There’s tons out there about fibroblast #mechanobiology in disease. In @ConfinementLab’s new review in @aplbioeng, Yeji gives you the who/what/where/when/how/why of mechanosensitive fibroblast activation, from CAFs to FAFs and nearly everything in between!

It’s been a long time coming but… so happy my Ph.D. work (part of) is now published on @NatureMaterials 🥳 I remember it all too well about this project, the serendipity and the exciting stories…🧵@nano_jenn @MBIsg @BME_NUS @NUSingapore https://t.co/pXrkADo42N

If your stack of images is full of defects, don't panic! InterpolaAI, a deep learning-based optical flow method, will fix issue tears, photobleaching and sticking artifacts for improved 3D imaging. Read our paper in Nature Methods: https://t.co/LIpzl3heoB

A must read paper from the Holle lab!

Fresh science! Check out our @ConfinementLab’s new paper on how confined migration can drive stem cell differentiation in @AdvPortfolio. Let’s do a thread! https://t.co/Ve5rWfy748 (1/n)

Immense congrats to my amazing postdoc @debanikch for winning the Best Poster Award at the 18th Nano-Bio Symposium at @INBT_JHU ! In just one year, he’s co-led a COCB article https://t.co/eH4TkeEZ7x…, a book chapter , and has several more in the pipeline. Well-deserved!

How do altered levels of lamins and other nuclear envelope proteins contribute to cancer metastasis, and how does this relate to #mechanobiology? Learn more in our recent review by @SarahHenretta now out in @Nature_NPJ - biological physics and mechanics ( https://t.co/k84fzeV5rt).

Excited to share our new publication https://t.co/j6Os9vlZNY , showing that viscoelastic matrix enhances cell plasticity and reprogramming efficiency. Congratulations and thanks to Yifan Wu, the team members, and collaborators!

Super excited to share the latest paper from my group published in @ScienceAdvances . "Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts" @JHUBME @JHU_ChemBE @INBT_JHU @HopkinsEngineer @JohnsHopkins https://t.co/ilfZ6HWbMo