Merlin Lange
@Merlin_Lange
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Project Lead - Senior Staff Scientist at the Chan Zuckerberg Biohub (@czbiohub).
San Francisco, CA
Joined December 2018
We recently launched https://t.co/FP1UgRFjk5 a resource for exploring the complexities of #zebrafish #development with #scRNAseq and #lightsheet. As #biology enters the era of big-data, we're excited to make navigating it easier. Come explore with us https://t.co/3PSCl7DQLq 1/8
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So excited to start the year w/ our new paper @CellCellPress! #proteomics spatial map of human cells + dynamics using #organelle IP at scale. 🙌 to amazing teamwork @czbiohub and beyond. Check out portal https://t.co/Gb1TvlKcCH and paper https://t.co/YskVRBUqZi. 1/n
cell.com
Organelle proteomics defines the cellular landscape of protein localization and highlights the role of subcellular remodeling in driving responses to perturbations such as viral infections.
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I am excited to join the next cohort of Allen Distinguished Investigators and looking forward to parsing the role of organelle interactions with imaging and AI in partnership with @cohenlaboratory and @AssafZaritsky!
How do organelles change over the course of a stem cell’s life? @cohenlaboratory, @AssafZaritsky, and @mattersOfLight are using machine learning and cell engineering to study the impact of organelle-organelle interactions on stem cell differentiation. #FrontierScience
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Having a blast at #MetabolismInAction2024 and thanks @nigrelex for your awesome science illustrations!
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Individuality is fascinating. Check how to quantify variability among individuals by identifying long motor strategies during navigation on small 🐟! Check the latest @wyartlab work from Dr. Gautam Sridhar & @antoniocbscosta @InstitutCerveau @PNASNews: https://t.co/unp0QhU4QC
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Very impressive! Congrats to all the team
Today in @NatureBiotech we report on the use of base and prime editing for high throughput interrogation of genetic variants in cancer. Excellent work by first authors @olivier_belli & @k_karava. 🧵👇 https://t.co/SEomr7ubwR
@ETH_en @ETH_BSSE
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🦓 Introducing #Zebrahub: a new #zebrafish developmental atlas from Drs. @Merlin_Lange, @LoicARoyer, and a team at the @CZbiohub! Check out the @CellCellPress paper: https://t.co/huHDXSWw1j Listen to the discussion on this week's episode: https://t.co/shyk2b8b7X
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We’re thrilled to announce that registration is now open for the 6th edition (on March 2025) of the Paris School on All-Optical Neuronal Circuits Control with Optogeentics and Multiphoton Microscopy! Join us and explore the latest breakthroughs with an outstanding lineup of
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These are the nuclei of individual cells, tracked with precision as they move throughout development in a zebrafish embryo. Captured thanks to custom-built microscopes + analysis tools made by @Merlin_Lange, @LoicARoyer + team at the #CZBiohubSF 🤩 https://t.co/2JeU7PtN23
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Using an embryo-model to study Hoxb13 regulation and its impact on tail growth. Now @PNASNews 🙏Lucille, Joska, Celia, Hocine et al👍@EPFL @UNIGEnews @cdf1530 @the_Node #InHoxWeTrust
https://t.co/TM4a1qbCfK
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🎓 Join us for our Spring School in Quantitative Biology: "Cell Dynamics in Developmental Systems" ✨ Featuring renowned speakers and hands-on workshops! Learn more and register: https://t.co/TVx8HcB2L4
#QuantBio #DevBio #QLife @ParisSciencesLet #PSLuniversity
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📢We have a 3y postdoc position available in our interdisciplinary team @institut_curie #Paris Join us if you're interested in epithelial tissue morphogenesis using live imaging, quantitative biology & (opto)genetics. https://t.co/uNmshuk1YI Please RT!
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Very normal day at the microscope with @loicaroyer 😄 #zebrahub
Understanding how a single cell develops into an entire body is one of biology’s biggest mysteries. Today we celebrate @Merlin_Lange + @loicaroyer & the team at #CZBiohubSF for publishing Zebrahub, a resource that gets us closer to solving this puzzle 🎉 https://t.co/2JeU7PtN23
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Now online! A multimodal zebrafish developmental atlas reveals the state-transition dynamics of late-vertebrate pluripotent axial progenitors
cell.com
Zebrahub is a comprehensive web-based atlas integrating spatiotemporal and transcriptional data at single-cell resolution to elucidate developmental state transitions in zebrafish.
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Understanding how a single cell develops into an entire body is one of biology’s biggest mysteries. New in @CellCellPress: #Zebrahub, a “Google Earth” of embryology, is helping crack the code. Read➡️ https://t.co/WdN3DeQE0A 🎥 @loicaroyer & @merlin_lange of #CZBiohubSF explain:
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Thrilled to share this milestone! Zebrahub atlas live in #Cell. A powerful fusion of #scRNAseq and #lightsheet imaging to map zebrafish development in real-time. Exciting step towards decoding embryogenesis! 🐟 🔬🧬#zebrafish #imaging #developmentalbiology
🚨Big news! Five years in the making, our Zebrahub paper is now published in #Cell 🎉. We’ve built a timecourse atlas of zebrafish embryonic development, combining #scRNAseq data and #lightsheet live imaging, and delved deep into the dynamics of key progenitors.
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Thrilled to share our new "Zebrahub-Multiome: Uncovering Gene Regulatory Network Dynamics During Zebrafish Embryogenesis"! 🐟 https://t.co/wtcNLgdZ1k Great effort lead by @yangjoonkim. Check out @loicaroyer thread 👇and explore the interactive ressource
zebrahub.sf.czbiohub.org
A dynamic atlas of zebrafish embryonic development that combines scRNAseq time-course data with lightsheet live imaging.
📡🧵 Excited to release two #bioRxiv preprints! The first preprint is: "Zebrahub-Multiome: Uncovering Gene Regulatory Network Dynamics During Zebrafish Embryogenesis" https://t.co/Hawozs4s5d We present a comprehensive time-resolved single-cell multiomic atlas of zebrafish
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Whistle variability and social acoustic interactions in bottlenose dolphins https://t.co/UV8CRfERlS This is a dream came true. Our first manuscript on dolphin communication is out. This is the work of Faadil and Chiara, in collaboration with @dePolavieja
biorxiv.org
Bottlenose dolphins exhibit a sophisticated social structure, known as a fission-fusion society. To sustain this complex system, dolphins rely on a rich vocal repertoire: clicks exclusively used for...
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So happy that our protocol paper which optimizes obtaining great quality single cells from a single Zebrafish embryo is finally out! Thanks a lot @Merlin_Lange @loicaroyer @mikeborjatweets for all the help!!😊 https://t.co/rCxDUwTxEb Our application : https://t.co/o9cE6jgY1C
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