Max Sosa
@maxbsosa
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JSPS Postdoctoral Fellow with Ikuro Abe | @MChangGroup + UC Berkeley alum | biosynthesis
Tokyo-to, Japan
Joined October 2018
RT @ScienceMagazine: New research in Science represents a notable step forward in designing enzymes from scratch. With a new approach, res….
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RT @EnzymeChemistry: Single-Enzyme Conversion of Tryptophan to Skatole and Cyanide Expands the Mechanistic Competence of Diiron Oxidases by….
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RT @TM81241003: JNP誌に第一著者のレビューが掲載されました!天然物の特殊アミノ酸生合成に関わるPLP依存置換反応をまとめました。
pubs.acs.org
Living organisms synthesize various nonproteinogenic amino acids (NPAAs) as the building blocks of natural products. These NPAAs are often biosynthesized by pyridoxal 5′-phosphate (PLP)-dependent...
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I'm ready to get back in the lab and continue to discover some interesting things about natural products and biosynthesis, as well as enjoy my new Tokyo life! 🧫🧬🧪👨🏻🔬🗼🏙️🗻.
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I'm very grateful to my PhD advisor @MChangGroup and a long-time mentor @hanzyduzit for their support in helping me get here! Of course, I'm grateful to Prof. Abe for taking this chance on me.
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I'm finally on my way! After a long, relaxing summer, I'm finally headed to Tokyo as a @jsps_sns Postdoctoral Fellowship. I'll spend the next few years working with Prof. Abe and the many talented scientists @UTokyo_News Lab of Natural Products Chemistry.
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RT @NirajMehta_chem: My PhD work studying the biosynthesis of medicinal natural products in plants is now published. Check it out!.
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RT @barra_lena: Very happy to share the final chapter of my postdoc time in the Abe group @UTokyo_News . Wondering how a PLP-dependent enzy….
nature.com
Nature Catalysis - Recently, the pyridoxal-5′-phosphate-dependent enzyme SbzP was reported to catalyse a [3+2]-annulation reaction yielding β-NAD-derived antibiotics. Now, cryo-electron...
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RT @LabSchulz: Unique highly hetero-substituted benzenes are defence compounds from tiny springtails. The minute amounts available needed t….
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RT @yanghaiBioChem: A Manic Monday? We are excited to bring you the first PLP enzyme catalyzing intermolecular Mannich reaction @J_A_C_S ht….
pubs.acs.org
α,β-Diamino acids are important structural motifs and building blocks for numerous bioactive natural products, peptidomimetics, and pharmaceuticals, yet efficient asymmetric synthesis to access these...
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Interesting how unrelated Fe-S clusters with different cluster geometries both facilitate LA-catalyzed DA reaction in biosynthesis. Would be cool to see how various ferredoxins fare against panels of inter/intramolecular DA substrates
nature.com
Nature Communications - Native enzymes using Lewis acid catalysis in intramolecular [4+2] cycloaddition remain unreported. Herein, the authors report the ferredoxins catalyzed [4+2] cycloaddition...
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RT @MChangGroup: Check out our review on the current state of biocatalysis. Congrats to the authors.
nature.com
Nature - This Review considers developments in enzymes, biosynthetic pathways and cellular engineering that enable their use in catalysis for new chemistry and beyond.
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What an unexpected strategy for making enediyne scaffolds!.
We are excited to finally publish the unprecedented biosynthetic origins of enediyne natural products: iodinated polyynes! This transformative discovery is a huge milestone for these clinical antitumor antibiotics. @Kalkreuter @guichun98 @nchembio .
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RT @MChangGroup: Big congratulations to our newly minted doctors, Dr. Max Sosa (@maxbsosa), Dr. Elijah Kissman, and Dr. Douglas Millar (@_P….
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Anyways, biology has so many unusual phenotypes and my favorite are chemical! Discovering interesting (bio)chemical phenotypes and how they interact with the world around them hopefully will lead me to long, exciting, and engaging career.
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And we began thinking about how these metabolites *could* facilitate plant-bacteria interactions! Much work is needed to make definitive claims, but I'm glad we could take even a small stab at the "raison d'etre" of this biochemical pathway, a too-often overlooked question.
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Thanks to the reviewers for helping us improve our paper and to @angew_chem throughout the editorial process. Overall, I think we were able to discover some interesting enzymatic reactivity and how we can manipulate a pathway for new molecule biosynthesis.
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We got the published version out! During review, we re-examined our stereochemical assignment of absolute configuration. Thanks to @biotools we were able to use vibrational circular dichroism to confidently assign the abs. config. of pazamide :).
Check out the published version in @angew_chem! .
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