Malachi Griffith
@malachigriffith
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Professor, Department of Medicine and McDonell Genome Institute @ Washington University. Specializing in Bioinformatics, Genomics, and Cancer.
Joined April 2011
Excited to announce Splam is now published in @GenomeBiology! Splam, trained on thousands of splice junctions from GTEx, is your go-to tool for scoring splice junctions from alignment or annotation files. @elapertea @StevenSalzberg1 @alan_mayonnaise
https://t.co/52pYjGhuRk
genomebiology.biomedcentral.com
The process of splicing messenger RNA to remove introns plays a central role in creating genes and gene variants. We describe Splam, a novel method for predicting splice junctions in DNA using deep...
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TCR constant region not exactly constant: "For TRBC1, ...83%...contained TRBC1∗03, 2 carried (11%) TRBC1∗01, and only a single haplotype carried TRBC1∗02. Lastly, for TRBC2, we identified 6 alleles, including 4 novel alleles..." https://t.co/pCImccSvAV
cell.com
Genetic variation within T cell receptor (TCR) genes influences the composition of the TCR repertoire and TCR-peptide-major histocompatibility complex interactions. Yet, diversity within human TCR...
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Our featured GCBR of the Week is CIViC, a community driven resource that improves the clinical interpretation of genetic variants in cancer. Click the link to find out more : https://t.co/05bQIVDYbd
@genome_gov
#globalbiodata
#openscience
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Applications are open for the Advanced Sequencing Technologies & Bioinformatics Analysis course @CSHL. This intense 2wk course will immerse you in genomics technologies and teach you the fundamental computational skills you need to analyze your own data. https://t.co/15oH5qhe4J
meetings.cshl.edu
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
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What's the fastest antigen-specific TCR discovery method that's practical (publicly available validated kit, <$5k per antigen, arbitrary HLA alleles)? What's better than just doing peptide+PBMC culture followed by 5'GEX+VDJ scRNA-seq?
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Anyone savvy CS x immunology x genomics looking for computational work?
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I am delighted to announce that I will be opening my lab on July 1 at Washington University in St Louis within the Division of Oncology, Department of Medicine, & Section of Computational Biology! @WUDeptMedicine @WashUFWIM 1/4
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If you are interested in this work, please consider applying here: https://t.co/X5mZYqUwAw ! 4/4
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A single-cell TCR-seq method for dogs suggests reannotation of some non-functional VJ genes and differentiates between diverse repertoires of healthy dogs and expanded repertoires in malignancies: https://t.co/Db5G1TpTO5
@obigriffith @WUDeptMedicine @malachigriffith
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Another opportunity that crossed my desk: https://t.co/4RQMXWsABa These folks are doing really cool stuff.
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Sharing this exciting opportunity for a colleague.
careers.ucalgary.ca
Assistant Professor in Cancer Biodiagnostics, Department of Biochemistry & Molecular Biology, Cumming School of Medicine in Calgary, AB, Canada
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So...is MALAT1 even a real thing? (it's so consistently the top hit in any expression analysis, I'm curious if any studies actually isolate its functionality rather than its pervasive correlation with *everything*)
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Such as: cloud computing, command line unix, bioinformatics tool installation, understanding NGS file formats, expression and DE analysis, pathway analysis, batch correction, R, IGV, etc. Some lectures with background principles, but a heavy emphasis on hands-on application.
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Highly recommend to take these two courses together as a 5-day intensive crash course in transcriptome analysis. Along the way we aim to teach fundamental bioinformatics skills with broad applicability.
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Registration is now open for CBW transcriptome and single cell transcriptome analysis workshops this summer in Toronto! https://t.co/4IruDtW1L1.
@Bioinfodotca
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If you are a PhD or Postdoc trainee or just getting your lab set up and you want to empower your own multi-omics data analysis, this course could be a great fit for you.
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For those who are not familiar. The course starts with a few days of introduction to sequencing technologies, both fundamentals and cutting edge developments. This is followed by an intensive and immersive crash course in bioinformatics.
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Only one week left to apply for the CSHL Advanced Sequencing Technologies & Bioinformatics Analysis course!
meetings.cshl.edu
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
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Want to expand your #bioinformatics toolkit by including #RNAseq or #scRNAseq? CBW is offering a pair of consecutive workshops in Toronto this July that will teach you how to investigate the transcriptome. Take one or both! https://t.co/4GcQh7ZuQP
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