Longhua Guo
@longhua_guo
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genetics | genomics | aging, regeneration and rejuvenation. Assistant Professor @ U of Michigan.
Joined July 2015
The summary: Aging, regeneration and whole-body rejuvenation in long-lived planarians.
nature.com
Nature Aging - We identified aging-associated changes in sexual strains of the extremely long-lived planarian Schmidtea mediterranea. Following amputation and regeneration in older animals,...
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RT @leo_jwu: Excited to share our new study in Cell—congrats to Daniel, co-authors, and our collaborators in the @PeterLyLab What began as….
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Planarians made the cover. Aging and Rejuvenation in planarians:
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RT @UM_CPOD: Join #CPOD, @TheSpenceLab & @longhua_guo tomorrow 5/20 at 4pm in Buhl 5915 for @KTsonis seminar!. #GoBlueMed #UmichMedScienc….
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RT @TheBaiLab: New publication from the lab @pnas . With the collaboration of Dr. Ping Kang @pingkang0, we uncovered how developmental NF-k….
pnas.org
Developmental time (or time to maturity) strongly correlates with an animal’s maximum lifespan, with late-maturing individuals often living longer....
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RT @ctmurphy1: C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1 | Science Advances https://t….
science.org
C. elegans’ TEI of learned pathogen avoidance is induced by a third bacterial small RNA, Pfs1, from P. fluorescens 15.
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RT @KevinMurachPhD: Chambers et al. w/@CoryDungan @Boehringer @prof_horvath @ClockFoundation @UKYCMB @UofA_ESRC @UARKHHPR @uacoehp @UArkRes….
onlinelibrary.wiley.com
Injury then recovery markedly rewires the DNA methylome in aged skeletal muscle.The addition of senolytics during muscle regeneration decelerates DNAmAGE more than regeneration alone as well as...
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RT @MicheleLabUM: Research from fellow Xiaoting Dai and the @longhua_guo lab in @UMPhysiology published in @NatureAging shows regeneration….
nature.com
Nature Aging - The freshwater planarian S. mediterranea is an important model organism for regeneration research but its use in aging research is little explored and S. mediterranea is commonly...
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RT @umichmedicine: Planarian worms can regenerate into a more youthful version of themselves, finds a new U-M study. Figuring out the secre….
michiganmedicine.org
Study finds planarian worms can regenerate into a more youthful version of themselves.
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The article: Regeneration leads to global tissue rejuvenation in aging sexual planarians.
nature.com
Nature Aging - The freshwater planarian S. mediterranea is an important model organism for regeneration research but its use in aging research is little explored and S. mediterranea is commonly...
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We identified aging-associated changes in sexual strains of the extremely long-lived planarian Schmidtea mediterranea. Following amputation and regeneration in older animals, aging-associated phenotypes were reversed to youthful states.
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Our work is now online at Nature Aging (, with exciting updates: comparison with mice/human aging; expanded number of samples for single cell analysis; molecular and cellular signatures of aging and rejuvenation; assay/discussion on global rejuvenation.
nature.com
Nature Aging - The freshwater planarian S. mediterranea is an important model organism for regeneration research but its use in aging research is little explored and S. mediterranea is commonly...
Our recent preprint addresses the challenges in studying aging in an "immortal" species, and found that the sexual planarians do get old. However, they have a way to reverse age, which is related to their whole body regenerative capacity.
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RT @TimePieChina: Planarian worms do not lose adult stem cells with age and can regenerate into a more youthful version of themselves, acco….
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RT @NatureAging: Online now! Dai et al. report age-associated physiological and molecular changes in the sexual lineage of S. mediterranea,….
nature.com
Nature Aging - The freshwater planarian S. mediterranea is an important model organism for regeneration research but its use in aging research is little explored and S. mediterranea is commonly...
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RT @PhysPlanaria: Excited to share our work on live imaging of the entire course of body regeneration in the marine flatworm Macrostomum us….
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RT @UM_CPOD: @UM_CPOD congratulates CPOD Members Sundeep Kalantry & @longhua_guo on their prestigious NIH awards! . Read more about their….
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