Gary Owens Lab UVA
@lab_owens
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UVA based cardiovascular research lab, SMC enthusiasts
Charlottesville, VA
Joined June 2018
Mouse Model of Spontaneous Heart Attack and Stroke @sohelszaman @beccadeaton @lab_owens @UVACVRC @AnitaSalamon_
https://t.co/JCSSYlArz9
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Excited to see our publication in press @CircAHA complete with a fantastic editorial by @Const_Delwarde @AikawaAikawaLab . Our study was featured in this week’s Circulation on the Run podcast. Congratulations @sohelszaman, @beccadeaton and co-authors!
ahajournals.org
BACKGROUND: Thromboembolic events, including myocardial infarction (MI) or stroke, caused by the rupture or erosion of unstable atherosclerotic plaques are the leading cause of death worldwide....
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Thanks for the excellent summary of our recent work @HaoYin20 ! Congratulations to @sohelszaman and @beccadeaton and all their coauthors for this fantastic study. @UVACVRC
A mouse model of #Atherosclerosis (SR-BI∆CT/∆CT;Ldlr−/− + #WesternDiet) mimics late-stage events of human disease😎 👉75% #MyocardialInfarction 👉38% #Stroke 👉31% #PlaqueRupture Similar lipid & liver enzyme profile to Ldlr-/-🐭except for 45% low HDL-C & body weight Does
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Congratulations to Dr. Karnewar and co-authors!
IL-1β promotes atherosclerosis but paradoxically is also required for diet-induced regression of advanced lesions and maintenance of a protective fibrous cap @InnovatieHester @gamze_b_bulut
@beccadeaton @DiezBenavente
https://t.co/7yD3gsezmt
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IL-1β promotes atherosclerosis but paradoxically is also required for diet-induced regression of advanced lesions and maintenance of a protective fibrous cap @InnovatieHester @gamze_b_bulut
@beccadeaton @DiezBenavente
https://t.co/7yD3gsezmt
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One of our two newly funded projects!
Gary Owens, PhD, was awarded a $3.2 million grant to study the role of IL-6 trans signaling in atherosclerosis development, which can cause heart attacks and strokes. @UVACVRC @uvahealthnews #UVASchoolofMedicine
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February Featured Article: A new autosomal Myh11-CreERT2 mouse allows inclusion of both sexes in SMC lineage-tracing and gene-knockout mouse studies @gamze_b_bulut @Anita_Salamon_
https://t.co/KJWZ8uFQT0
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Today we celebrate the amazing women in the Owens Lab in honor of International Day of Women and Girls in Science @Anita_Salamon_ , Victoria Milosek, @beccadeaton , Noelle Koo, Alex Krinsky, Rupa Tripathi, Laura Shankman #internationalwomenandgirlsinscienceday #whorunstheworld
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A new autosomal Myh11-CreERT2 mouse allows inclusion of both sexes in SMC lineage-tracing and gene-knockout mouse studies @gamze_b_bulut @Anita_Salamon_
https://t.co/sTQy98vqdr
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We are excited to share our new autosomal Myh11-CreERT2 mouse model to enable smooth muscle cell specific KO & lineage tracing in both MALE & FEMALE mice! (Previous 🐭 was Y-linked) @atvbahajournals @beccadeaton
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A new study led by Dr. Gary Owens (@lab_owens) at @MedicineUVA has determined the function of Lgals3-transitioned inflammatory smooth muscle cells in #atherosclerosis. 📌 Read more: https://t.co/KbvIc4fU1M
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🏆 Best of #NatMetab2021 | CITATIONS #18 Exploring the origins of myofibroblasts in atherosclerotic fibrous caps, @lab_owens (@UVA), @aacnewman13 (@nyulangone), @DrVladPhD, @ScientistBaylis find that smooth muscle cells are required for plaque stability. https://t.co/Xq2CoGVTfS
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Many heart attacks and strokes are caused by unstable atherosclerotic plaques, which accumulate in our arteries. Researchers believe they could strengthen the plaque's fibrous caps and prevent these conditions. https://t.co/KOoC5Fkjdg
@UVACVRC @AmericanHeartVA
uvahealth.com
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Big congratulations to @AlencarGF and @katieows and co-authors on their recent Circulation paper! #scRNAseq #SMCplasticity
https://t.co/of2BOvak5c
ahajournals.org
Background: Rupture and erosion of advanced atherosclerotic lesions with a resultant myocardial infarction or stroke are the leading worldwide cause of death. However, we have a limited understanding...
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It’s #CRISPR. Emmanuelle Charpentier and Jennifer Doudna ,who pioneered the revolutionary gene-editing technology, are the winners of this year’s #NobelPrize in Chemistry. #NobelPrize2020
https://t.co/I9uqEE41or
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