LMBLib
@LMB_Library
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NEW #LMBPublications FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology
pubmed.ncbi.nlm.nih.gov
Immunoglobulin G (IgG) is traditionally recognized as a plasma protein that neutralizes antigens for immune defense. However, our research demonstrates that IgG predominantly accumulates in adipose...
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NEW #LMBPublications Structural insights into a DNA polymerase reading the xeno nucleic acid HNA
pubmed.ncbi.nlm.nih.gov
Xeno nucleic acids (XNAs) are unnatural analogues of the natural nucleic acids in which the canonical ribose or deoxyribose rings are replaced with alternative sugars, congener structures or even...
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NEW #LMBPublications Efficient circular RNA synthesis for potent rolling circle translation
pubmed.ncbi.nlm.nih.gov
Circular RNA (circRNA) is a candidate for next-generation messenger RNA therapeutics owing to its remarkable stability. Here we describe trans-splicing-based methods for the synthesis of circRNAs...
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NEW #LMBPublications Modelling human brain development and disease with organoids
pubmed.ncbi.nlm.nih.gov
Organoids are systems derived from pluripotent stem cells at the interface between traditional monolayer cultures and in vivo animal models. The structural and functional characteristics of organoids...
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NEW #LMBPublications CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription
pubmed.ncbi.nlm.nih.gov
Control of RNA polymerase II (RNA Pol II) through ubiquitylation is essential for the DNA-damage response. Here, we reveal a distinct ubiquitylation pathway in human cells, mediated by CRL3ARMC5,...
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NEW #LMBPublications Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus
pubmed.ncbi.nlm.nih.gov
Type IV pili (T4Ps) are abundant in many bacterial and archaeal species, where they play important roles in both surface sensing and twitching motility, with implications for adhesion, biofilm...
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NEW #LMBPublications A framework for neural organoids, assembloids and transplantation studies
pubmed.ncbi.nlm.nih.gov
As the field of neural organoids and assembloids expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and...
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NEW #LMBPublications A finger that gets in the way: When binding isn't just about the bound state
pubmed.ncbi.nlm.nih.gov
In this issue of Structure, Viennet et al.1 report a study characterizing the DNA binding by a three-zinc-finger fragment from the transcription factor BCL11A, with the unusual feature that an...
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NEW #LMBPublications A cryo-electron tomography study of ciliary rootlet organization
pubmed.ncbi.nlm.nih.gov
Ciliary rootlets are striated bundles of filaments that connect the base of cilia to internal cellular structures. Rootlets are critical for the sensory and motile functions of cilia. However, the...
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NEW #LMBPublications Structure and methyl-lysine binding selectivity of the HUSH complex subunit MPP8
pubmed.ncbi.nlm.nih.gov
The Human Silencing Hub (HUSH) guards the genome from the pathogenic effects of retroelement expression. Composed of MPP8, TASOR, and Periphilin-1, HUSH recognizes actively transcribed retrotranspo...
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NEW #LMBPublications LXR regulation of adipose tissue inflammation during obesity is associated with dysregulated macrophage function
pubmed.ncbi.nlm.nih.gov
Our study highlights distinct roles for each LXR isoform in AT inflammation regulation, with LXRβ being crucial for maintaining the anti- and proinflammatory balance in ATMs. Thus, LXRβ holds...
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NEW #LMBPublications Improving macromolecular structure refinement with metal-coordination restraints
pubmed.ncbi.nlm.nih.gov
Metals are essential components for the structure and function of many proteins. However, accurate modelling of their coordination environments remains a challenge due to the complexity and diversity...
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NEW #LMBPublications RNA-Puzzles Round V: blind predictions of 23 RNA structures
pubmed.ncbi.nlm.nih.gov
RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA three-dimensional structure prediction. With agreement from structural biologists, RNA structures are predic...
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NEW #LMBPublications Identification of a factor that accelerates substrate release from the signal recognition particle
pubmed.ncbi.nlm.nih.gov
The eukaryotic signal recognition particle (SRP) cotranslationally recognizes the first hydrophobic segment of nascent secretory and membrane proteins and delivers them to a receptor at the endopla...
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NEW #LMBPublications Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge
pubmed.ncbi.nlm.nih.gov
A wide variety of systemic pathologies, including infectious and autoimmune diseases, are accompanied by joint pain or inflammation, often mediated by circulating immune complexes (ICs). How such...
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NEW #LMBPublications New players and targets in mannose 6-phosphate-dependent lysosomal sorting
pubmed.ncbi.nlm.nih.gov
The Golgi apparatus serves multiple crucial roles in the cell. These roles include the addition and subsequent modification of glycans, not only to newly-made proteins arriving from the endoplasmic...
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NEW #LMBPublications A physical model for M1-mediated influenza A virus assembly
pubmed.ncbi.nlm.nih.gov
Influenza A virus particles assemble at the plasma membrane of infected cells. During assembly all components of the virus come together in a coordinated manner to deform the membrane into a protru...
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NEW #LMBPublications Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease
pubmed.ncbi.nlm.nih.gov
The abnormal assembly of tau protein in neurons is a pathological hallmark of multiple neurodegenerative diseases, including Alzheimer's disease (AD). Assembled tau associates with extracellular...
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