Luciano A. Masullo
@l_masu
Followers
2K
Following
11K
Media
106
Statuses
1K
Physicist | single molecules, bioscience, biotech, nanotech, optics, fluorescence | Project Leader @JungmannLab @MPI_Biochem
Munich, Bavaria
Joined February 2011
ÅNGSTRÖM-RESOLUTION FLUORESCENCE MICROSCOPY. Can we do structural biology with an optical microscope? Yes! Check out how we resolved *single bases of DNA* and much more using fluorescence microscopy, out today in @Nature! https://t.co/i9bGl2Vq40
@JungmannLab @MPI_Biochem
30
381
1K
Three weeks ago, we welcomed the participants of the EMBO | EMBL Symposium 'Seeing is believing: imaging the molecular processes of life' 🔬🦠 Today, we're excited to announce the #EESImaging poster prize winners. The poster prize committee elected three winners. 👏 A big
0
1
6
Thread describing our work: https://t.co/WuKedsqitT
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
https://t.co/ukJcD7aZsE
0
1
7
Our article "Ångström-resolution imaging of cell-surface glycans" on the cover of Nature Nanotechnology! 🤩 @NatureNano
https://t.co/DHWKUV2Bmt
3
11
90
🔬📱 Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope. Our latest work published in Nature Communications. https://t.co/hxOZw7aNaE
nature.com
Nature Communications - Loretan and colleagues present a low-cost smartphone-based microscope capable of detecting single-molecule fluorescence. This approach opens doors to personalised and widely...
3
26
89
I am also very grateful to my previous mentors, Dr. Ralf Jungmann (@JungmannLab) and Dr. Fernando D. Stefani (@FerStefaniLab), and many other amazing colleagues who have supported me throughout my career.
0
0
7
I am very grateful to Dr. Gabriel A. Rabinovich (@gabyrabi) for his generous sponsorship and guidance throughout the application process, and I look forward to developing my research program within the stimulating environment of the Glycosciences Program at IBYME.
2
0
7
I’ll soon be looking for Master’s students, PhD students, and a postdoc to join the team—so if this sounds exciting to you, please don’t hesitate to reach out!
1
0
8
My research will focus on deciphering cell signaling at the molecular level by applying and developing cutting-edge super-resolution methods, with a particular emphasis on glycoimmune checkpoints, aiming to translate this knowledge into novel and improved therapies.
1
0
6
This grant gives me the opportunity to start building my own group, with support for setting up a state-of-the-art super-resolution microscopy lab.
1
0
9
Thrilled to announce some big news! I’ve been awarded a Wellcome Trust Early Career Award to establish my research as a Group Leader in the Glycosciences Program at the Institute of Biology and Experimental Medicine (IBYME) in Buenos Aires, Argentina, starting early 2026.
19
14
251
Within this neuronal atlas we can reveal the three synapse classes, excitatory, inhibitory and the recently discovered mixed synapse. Organelle imaging of Peroxisomes (Pmp70) and the Golgi Apparatus (Golga5) reveals rare contact sides and even fused particles. (5/6)
1
2
4
To show the power of the technique, we acquired a 13-plex 200 x 200 µm2 neuronal atlas in 3D. With this atlas, we map the interaction architecture of three neurons, resolving organelles, cytoskeleton, vesicles and synapses at single-protein resolution. (4/6)
1
1
2
We demonstrate speed-optimized left-handed DNA-PAINT by characterizing the sequence binding kinetics and resolving three main microscopy benchmarking targets, mitochondria, microtubules and nuclear pore complexes with < 5 nm localization precision. (3/6)
1
1
3
The mirrored design of left-handed oligonucleotides allows the extension of the common 6 speed-sequences R1-R6 with their analogs L1-L6, enabling 12 target multiplexing with a standard secondary label-free DNA-PAINT workflow. (2/6)
1
1
3
Highly efficient 12-color multiplexing with speed-optimized DNA-PAINT. We are excited to share our latest publication in @NatureComms, using left-handed DNA to extend speed-optimized DNA-PAINT to 12 targets in a simple and straightforward way! 🧬👈🚀 https://t.co/dIUn2CbxmI
nature.com
Nature Communications - By combining left- and right-handed DNA-PAINT probes, Unterauer et al. achieve simple, robust, and highly multiplexed super-resolution. They show 13-plex neuronal maps,...
1
24
99
Happy to share this article with my views on @EliSlenders and @VicidominiLab work and discussing current developments in single-molecule localization combining structured excitation and detection. So many exciting perspectives in the field! https://t.co/FQ5bz6LtJb
nature.com
Light: Science & Applications - Localization of single molecules with structured illumination and structured detection
1
4
21
Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes https://t.co/5ZpyA7EMKT
nature.com
Nature - Super-resolution technique works with off-the-shelf optical microscopes.
4
50
250
Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes https://t.co/pIlv9CsdLo
nature.com
Nature - Super-resolution technique works with off-the-shelf optical microscopes.
5
69
244
Now published in Nature Nanotechnology! 🤩 @NatureNano
https://t.co/FtSrLSHmf7
nature.com
Nature Nanotechnology - By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the...
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
https://t.co/ukJcD7aZsE
5
9
85
Now online: Ångström-resolution imaging of cell-surface glycans. The molecular organization of sugars in the native #glycocalyx has been resolved at 9 Å using bioorthogonal metabolic labeling & #superresolution imaging of DNA barcodes. #Glycotime
https://t.co/HmPzI6ghpa
nature.com
Nature Nanotechnology - By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the...
0
22
78