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Luciano A. Masullo Profile
Luciano A. Masullo

@l_masu

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Physicist | single molecules, bioscience, biotech, nanotech, optics, fluorescence | Project Leader @JungmannLab @MPI_Biochem

Munich, Bavaria
Joined February 2011
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@l_masu
Luciano A. Masullo
2 years
ÅNGSTRÖM-RESOLUTION FLUORESCENCE MICROSCOPY. Can we do structural biology with an optical microscope? Yes! Check out how we resolved *single bases of DNA* and much more using fluorescence microscopy, out today in @Nature! https://t.co/i9bGl2Vq40 @JungmannLab @MPI_Biochem
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@EMBLEvents
EMBL Events
17 days
Three weeks ago, we welcomed the participants of the EMBO | EMBL Symposium 'Seeing is believing: imaging the molecular processes of life' 🔬🦠 Today, we're excited to announce the #EESImaging poster prize winners. The poster prize committee elected three winners. 👏 A big
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@l_masu
Luciano A. Masullo
29 days
Thread describing our work: https://t.co/WuKedsqitT
@JungmannLab
Jungmann Lab
9 months
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS  🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy https://t.co/ukJcD7aZsE
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@l_masu
Luciano A. Masullo
29 days
Our article "Ångström-resolution imaging of cell-surface glycans" on the cover of Nature Nanotechnology! 🤩 @NatureNano https://t.co/DHWKUV2Bmt
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@Guille_P_Acuna
Guillermo Acuña
1 month
🔬📱 Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope. Our latest work published in Nature Communications. https://t.co/hxOZw7aNaE
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nature.com
Nature Communications - Loretan and colleagues present a low-cost smartphone-based microscope capable of detecting single-molecule fluorescence. This approach opens doors to personalised and widely...
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@l_masu
Luciano A. Masullo
1 month
I am also very grateful to my previous mentors, Dr. Ralf Jungmann (@JungmannLab) and Dr. Fernando D. Stefani (@FerStefaniLab), and many other amazing colleagues who have supported me throughout my career.
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@l_masu
Luciano A. Masullo
1 month
I am very grateful to Dr. Gabriel A. Rabinovich (@gabyrabi) for his generous sponsorship and guidance throughout the application process, and I look forward to developing my research program within the stimulating environment of the Glycosciences Program at IBYME.
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@l_masu
Luciano A. Masullo
1 month
I’ll soon be looking for Master’s students, PhD students, and a postdoc to join the team—so if this sounds exciting to you, please don’t hesitate to reach out!
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@l_masu
Luciano A. Masullo
1 month
My research will focus on deciphering cell signaling at the molecular level by applying and developing cutting-edge super-resolution methods, with a particular emphasis on glycoimmune checkpoints, aiming to translate this knowledge into novel and improved therapies.
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@l_masu
Luciano A. Masullo
1 month
This grant gives me the opportunity to start building my own group, with support for setting up a state-of-the-art super-resolution microscopy lab.
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@l_masu
Luciano A. Masullo
1 month
Thrilled to announce some big news! I’ve been awarded a Wellcome Trust Early Career Award to establish my research as a Group Leader in the Glycosciences Program at the Institute of Biology and Experimental Medicine (IBYME) in Buenos Aires, Argentina, starting early 2026.
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@JungmannLab
Jungmann Lab
2 months
Within this neuronal atlas we can reveal the three synapse classes, excitatory, inhibitory and the recently discovered mixed synapse. Organelle imaging of Peroxisomes (Pmp70) and the Golgi Apparatus (Golga5) reveals rare contact sides and even fused particles. (5/6)
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@JungmannLab
Jungmann Lab
2 months
To show the power of the technique, we acquired a 13-plex 200 x 200 µm2 neuronal atlas in 3D. With this atlas, we map the interaction architecture of three neurons, resolving organelles, cytoskeleton, vesicles and synapses at single-protein resolution. (4/6)
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@JungmannLab
Jungmann Lab
2 months
We demonstrate speed-optimized left-handed DNA-PAINT by characterizing the sequence binding kinetics and resolving three main microscopy benchmarking targets, mitochondria, microtubules and nuclear pore complexes with < 5 nm localization precision. (3/6)
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@JungmannLab
Jungmann Lab
2 months
The mirrored design of left-handed oligonucleotides allows the extension of the common 6 speed-sequences R1-R6 with their analogs L1-L6, enabling 12 target multiplexing with a standard secondary label-free DNA-PAINT workflow. (2/6)
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@JungmannLab
Jungmann Lab
2 months
Highly efficient 12-color multiplexing with speed-optimized DNA-PAINT. We are excited to share our latest publication in @NatureComms, using left-handed DNA to extend speed-optimized DNA-PAINT to 12 targets in a simple and straightforward way! 🧬👈🚀 https://t.co/dIUn2CbxmI
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nature.com
Nature Communications - By combining left- and right-handed DNA-PAINT probes, Unterauer et al. achieve simple, robust, and highly multiplexed super-resolution. They show 13-plex neuronal maps,...
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@l_masu
Luciano A. Masullo
2 months
Happy to share this article with my views on @EliSlenders and @VicidominiLab work and discussing current developments in single-molecule localization combining structured excitation and detection. So many exciting perspectives in the field! https://t.co/FQ5bz6LtJb
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nature.com
Light: Science & Applications - Localization of single molecules with structured illumination and structured detection
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@Nature
nature
4 months
Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes https://t.co/5ZpyA7EMKT
nature.com
Nature - Super-resolution technique works with off-the-shelf optical microscopes.
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@Nature
nature
4 months
Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes https://t.co/pIlv9CsdLo
nature.com
Nature - Super-resolution technique works with off-the-shelf optical microscopes.
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@l_masu
Luciano A. Masullo
4 months
Now published in Nature Nanotechnology! 🤩 @NatureNano https://t.co/FtSrLSHmf7
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nature.com
Nature Nanotechnology - By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the...
@JungmannLab
Jungmann Lab
9 months
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS  🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy https://t.co/ukJcD7aZsE
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@NatureNano
Nature Nanotechnology
4 months
Now online: Ångström-resolution imaging of cell-surface glycans. The molecular organization of sugars in the native #glycocalyx has been resolved at 9 Å using bioorthogonal metabolic labeling & #superresolution imaging of DNA barcodes. #Glycotime https://t.co/HmPzI6ghpa
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nature.com
Nature Nanotechnology - By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the...
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