Kseniia Prokofeva
@ks_prokofeva
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Assistant Professor @sciencetokyo_en Kuroda Lab | Maternal and affiliative social behavior | PhD @UNIV_TSUKUBA_EN @WPI_IIIS | MD | She/her | Views my own | 💙💛
Japan
Joined February 2021
My first ever first author paper and PhD work is out in @SfNJournals ’ #JNeurosci! In this paper, we’ve discovered a new neuronal circuit governing sleep/wake behavior. 1/10 https://t.co/eBgkeS3Rr0
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Excited to present at #JNS2025 in Niigata tomorrow (7/26) as part of Science Tokyo @ Kuroda Lab! Sharing our work on adversity-overcoming infant rescue behavior in female mice and its neurobiology 🧠🛟 Looking forward to discussions!
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Our Nature Communications paper is out! We present CaliAli 🧠—a MATLAB toolbox for aligning & extracting neurons across 1p imaging sessions. Tracks signals across months using vasculature-based alignment. Open-source & documented. Paper:
nature.com
Nature Communications - Neural data analysis algorithms capable of tracking neuronal signals from one-photon functional imaging data longitudinally and reliably are still lacking. Here authors...
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家庭と科学大のWin-Winな関係を目指すアプリです。 スマートベビー家電への発展も開発中👇👇👇 東京科学大、乳児の睡眠と泣きの問題を科学的に支援する研究用スマートフォンアプリSciBabyを開発 - #日本経済新聞
nikkei.com
【プレスリリース】発表日:2025年02月27日乳児の泣き止みと寝かしつけをITで支援－ウェアラブル連携アプリSciBabyをリリース－【ポイント】○スマートフォンアプリSciBaby（サイベビー）は科学的根拠に基づき、効果的な抱き歩き・寝かしつけのタイミングを音声でサポートします。○腕時計型脈拍センサと連携して乳児の生理的状態を可視化し、乳児ごとに最適な寝かしつけタイミングをAIが
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Very proud of my former PhD supervisor Dr. Arisa Hirano on receiving the Tsukuba Encouragement Prize! She is an incredibly talented scientist and a fantastic mentor. Well deserved!
平野有沙助教が、第34回つくば奨励賞（若手研究者部門）を受賞しました。 平野助教は「概日時計の破綻による概日リズム障害発症メカニズムの解明と、その治療法の開発に資する研究」と題する研究が高く評価され、今回の受賞となりました。 🔗 https://t.co/7plrKBhL5y
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How do we form new social connections? 🧠✨ My PhD lab’s new study dives into the brain mechanism behind this fascinating process. Check out their findings.
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How mammalian #parenting has evolved, and how extended into complex affiliative social behaviors in 330 million years? We review these issues in "Parental Brain Through Time" published at Annals of the New York Academy of Sciences! Free download👉 https://t.co/GoFHi8XtAy
nyaspubs.onlinelibrary.wiley.com
This review explores the potential origins and subsequent evolution of mammalian parental care. The fundamental neural circuitry underlying mammalian parental care likely traces its roots to hypoth...
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Just found this great new fiber photometry primer and realized how much it could’ve spared me from suffering if it had existed when I was learning about FP almost through gossips and whispers or colleagues. Recommend to anyone approaching FP!
Santa came early for the nerds who asked for a Fiber Photometry Primer for Xmas! It’s been fab working across 9 time zones w/ Eleanor Simpson, Thomas Akam, @tpatriarchi , @MartaBlancoPozo ,@WaltonLabNeuro , @mohebial , & @StephCragg . https://t.co/aiqREnwLPH
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The #hypothalamus plays a large role in coordinating the array of neuronal signals that are responsible for keeping the body in a stable state. A special issue of Science unpacks this key brain region’s impact on physiological and behavioral homeostasis. https://t.co/TRJltFWmTF
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Thanks so much to my mentors @TakeshiSakurai and Dr. Arisa Hirano at @UNIV_TSUKUBA_EN ’s @WPI_IIIS , all members of Sakurai/Hirano lab, especially @clegyo , and all people involved!
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In summary, we provided a comprehensive and exhaustive histological background for further elucidation of components of the sleep/wake circuitry and showed a different insight into the physiological role of the VLPO→LHA neural pathway in the sleep/wakefulness regulation. 10/10
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Despite these optogenetics results being surprising, they are in align with the results of resent studies and overall suggest that VLPO contains a heterogeneous neuronal population and plays a more intricate role in the regulation of sleep/wake behavior than expected. 9/10
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However, similar photostimulation of axons of the GAL VLPO neurons in the LHA did not affect wakefulness. 8/10
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We next examined function of the GABA and GAL VLPO neurons projecting to the LHA by optogenetic stimulation of their axons in the LHA. Surprisingly, we found that stimulation of axons of the GABA VLPO neurons induced and transiently increased wakefulness! 7/10
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We also compared these input neurons using multidimensional scaling analysis and Spearman correlation. Big shout out to @pabloivg for these analyses. The results suggested that GABA and GAL VLPO neurons projecting to the LHA might be (partially) a single neuronal population! 6/10
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Next, we examined whole-brain input neurons of GABA and GAL VLPO neurons projecting to the LHA, using projection-specific rabies virus tracing, and found their inputs in functionally diverse brain areas regulating sleep/wake behavior, body temperature and other functions. 5/10
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We first identified that GABA (Vgat)- and GAL (Gal) VLPO neurons make direct synaptic inputs to orexin neurons in the LHA, using retrograde rabies virus tracing and in situ hybridization. It was especially exciting to find the connection between GAL VLPO and orexin neurons! 4/10
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We focused on deciphering of the structural and functional connection between these anatomical areas and their neuronal populations, and on a large-scale mapping of the sleep/wake circuitry from the perspective of this connection. 3/10
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GABA- and galanin (GAL)-producing neurons in the ventrolateral preoptic nucleus (VLPO) are known to participate in the initiation of sleep, while orexin (hypocretin)-producing neurons in the lateral hypothalamic area (LHA) are indispensable for consolidation of wakefulness. 2/10
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🧪🧠 Our latest #neuroscience paper presents #CaliAli, a game-changing neuron-tracking tool for one-photon calcium imaging! CaliAli excels at detecting weak signals & maximizes the number of trackable neurons. 🚀💡 @masanorisaka. 1/4 https://t.co/jXh4b8OIYP
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