Krauthammer Lab
@krauthammerlab
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Clinical and translational informatics news from the lab of Michael Krauthammer | @UZH_en and @Unispital_USZ Ran by KLab members π©βπ»π¨βπ»
Joined April 2013
Our latest study "Machine learning prediction of prime editing efficiency across diverse chromatin contexts" is out @NatureBiotech! Shout out to our awesome collaborators @nicopmat @schwanklab @bvansteensellab and all (co)-authors π https://t.co/G5C7CgpSQ5
@UZH_Science @DQBM_uzh
nature.com
Nature Biotechnology - A machine learning model for prime editing efficiency prediction takes into account chromatin context.
Our paper exploring the effect of chromatin on prime editing and diverse pegRNA designs was published today! π¨βπ»π§¬π https://t.co/hoygYAHbPH
https://t.co/xvSlhTJvNV
@UZH_Science @NatureBiotech @schwanklab @krauthammerlab @bvansteensellab π§΅
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Our preprint "TAMER: A Test-Time Adaptive MoE-Driven Framework for EHR Representation Learning" is out! A great work by @yhzhu99 @XiaochenZheng3 π Paper: https://t.co/8MDD76pJ4a
#MachineLearning #Healthcare @UZH_en @DQBM_uzh
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π Wrapping up 2024 with a bang! Check out our exciting ArXiv paper: "Explainable Multi-Modal Data Exploration in Natural Language via LLM Agent." π AI just got smarter and more accessible. Here's to 2025! π #Multimodality #AgenticAI #ExplainableAI #LLMs
https://t.co/RIjiWLHIhB
arxiv.org
International enterprises, organizations, or hospitals collect large amounts of multi-modal data stored in databases, text documents, images, and videos. While there has been recent progress in...
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Please RT and share widely! #MachineLearning #healthcare #phd #ArtificialIntelligence #biomedicine #oncology
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ππ
π°πΆππΆπ»π΄ π£π΅π π’π½π½πΌπΏπππ»πΆππ πΆπ» ππ π³πΌπΏ π£πΏπ²π°πΆππΆπΌπ» π’π»π°πΌπΉπΌπ΄π in Our Lab! Candidate will work on AI-driven precision oncology, developing solutions that could revolutionize how we approach cancer treatment. Apply π https://t.co/Oo7hSW62vF
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I am hiring a PhD student to join our team at the Medical Informatics at UZH and work on an exciting SNSF project starting early next year. SNF PhD position in Medical NLP Please share ππ... https://t.co/zh1DIfYS3n
#uzh, #krauthammerlab
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π«We are hiring a PhD student to join us and work on an exciting SNSF project starting early next year. "SNF PhD position in Medical Informatics with a Focus on Natural Language Processing" Please share π https://t.co/7DAJP9XcK6
@farhadnz
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Bridging genome editing, protein engineering, and applied machine learning in biology: Great to see our latest study, spearheaded by @marquark, out in @naturemethods. Check out the paper! π§¬π· https://t.co/hANtAKwFEm
@nicopmat @schwanklab @krauthammerlab
nature.com
Nature Methods - This work introduces engineered TnpBmax proteins with enhanced efficiency and an expanded targeting range. By leveraging an extensive dataset on editing efficiencies, it also...
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And read the Research Briefing on the work here: https://t.co/tfT2FyOl8a
.@schwanklab and colleagues describe TnpB variants with increased activity and a broader targeting range, along with a deep learning model to predict ΟRNA efficiency. @marquark @nicopmat @Amina_mollaysa @krauthammerlab
https://t.co/lakYFNn3ot
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.@schwanklab and colleagues describe TnpB variants with increased activity and a broader targeting range, along with a deep learning model to predict ΟRNA efficiency. @marquark @nicopmat @Amina_mollaysa @krauthammerlab
https://t.co/lakYFNn3ot
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If you're more of a visual learner, this explainer video is for you π
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Our TnpB story has been published in @naturemethods π Check out the thread by @schwanklab to dive right in.
Excited to share our latest study! Today in @naturemethods the @schwanklab and @krauthammerlab report in @marquark et al. 'Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ΟRNAs' (1/6) https://t.co/lqDc5Kn2Xw
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TnpB is much smaller than the well-known CRISPR-Cas "gene scissors". The tool for targeted modification of the genome has now been improved to such an extent that it could one day be used to treat a genetic defect that leads to a lifelong high cholesterol level.
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TnpB ist viel kleiner als die bekannte Β«GenschereΒ» CRISPR-Cas. Nun wurde das Tool zur gezielten VerΓ€nderung des Genoms so verbessert, dass es dereinst zur Behandlung eines Gendefekts eingesetzt werden kΓΆnnte, der zu einem lebenslang stark erhΓΆhten Cholesterinspiegel fΓΌhrt.
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Check the @naturemethods research briefing associated with our latest study on TnpB for effective genome editing https://t.co/zmIfUECkxo
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Our latest collab with @schwanklab is out today! "Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ΟRNAs" https://t.co/K5EfaMgOKB Congrats to all authors & collaborators!ππ @marquark @Amina_mollaysa @DQBM_uzh @Unispital_USZ @UZH_H2R
nature.com
Nature Methods - This work introduces engineered TnpBmax proteins with enhanced efficiency and an expanded targeting range. By leveraging an extensive dataset on editing efficiencies, it also...
Excited to share our latest study! Today in @naturemethods the @schwanklab and @krauthammerlab report in @marquark et al. 'Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ΟRNAs' (1/6) https://t.co/lqDc5Kn2Xw
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Bridging genome editing, protein engineering, and applied machine learning in biology: Great to see our latest study, spearheaded by @marquark, out today in @naturemethods. Check out the paper! π§¬π» @UZH_Science @schwanklab @krauthammerlab
nature.com
Nature Methods - This work introduces engineered TnpBmax proteins with enhanced efficiency and an expanded targeting range. By leveraging an extensive dataset on editing efficiencies, it also...
Excited to share our latest study! Today in @naturemethods the @schwanklab and @krauthammerlab report in @marquark et al. 'Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ΟRNAs' (1/6) https://t.co/lqDc5Kn2Xw
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Our work "Rethinking Molecular Design: Integrating Latent Variable and Auto-Regressive Models for Enhanced Goal Directed Generation" got accepted at the ICML 2024 Workshop AccMLBio! Great work by Arthur-Louis Heath and @Amina_mollaysa ππ! ποΈ https://t.co/sIFGryCcfa
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'Explainable deep learning for disease activity prediction in chronic inflammatory joint diseases' is now out in @PLOSDigiHealth @cecile_tt @CarolineOspelt ππ Paper:
Our preprint "Explainable deep learning for disease activity prediction in chronic inflammatory joint diseases" is out! A great work by @cecile_tt and all collaborators @CarolineOspelt at @Unispital_USZ ππ! Paper: https://t.co/CWiIURHPU1
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