Bas van Steensel lab
@bvansteensellab
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Chromatin Genomics lab at the Netherlands Cancer Institute. We study genome architecture, chromatin and gene regulation by means of new genomics methods.
Amsterdam, The Netherlands
Joined June 2018
If you did not abandon this platform yet (it really is time to go!): In addition to LinkedIn, you can now also find us on Bluesky: . @basvansteensellab.bsky.social.
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We are leaving Twitter/X and we will instead post our lab's news on Thanks for following us, we hope to see you there!.
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New preprint by our lab -- Revealing the functional landscape of a large genomic locus by highly multiplexed local hopping of a reporter: Even a 'simple' genomic locus such as the mouse Sox2 locus still holds surprises. .
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We generated a collection of new and optimised (and multiplexable) TF reporters for human and mouse cells:
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The first preprint of our PERICODE consortium: MPRA-trained deep learning provides insight into the regulatory logic of promoters and transcription factors.
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. and we used our platform of 19 chromatin-integrated pathway reporters to probe context-dependent effects of epigenetic drugs on Cas9 editing:
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We identified a complex network of proteins that regulate MMEJ:NHEJ repair pathway balance in a chromatin context-dependent manner. With impact on cancer genomes. Paper is finally out:
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See also Lise's explanation on our Open Science blog:
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New preprint from our lab: LAD scrambling to figure out how they interact with the nuclear lamina.
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New preprint from our lab: E-E-P massively parallel reporter assay to understand how signals from *two* enhancers are integrated by promoters:
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New preprint from our lab: Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements.
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NKI PhD program, this year with several positions focused on chromosome biology and gene regulation, is open for applications.
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Our lab has a postdoc position available! Several possible projects in functional genomics of gene regulation, using exciting new approaches. Computional, wet-lab or both. If you are interested: contact us at b.v.steensel@nki.nl.
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We have a position available for a Technician. Would you like to work on new genomics techniques and do you like to work in a team? See for info about our research. Please send your application letter + CV to b.v.steensel@nki.nl.
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We identified dozens of DNA double-strand break repair proteins that modulate MMEJ:NHEJ balance depending on the local chromatin context:
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Our paper on the impact of CTCF and cohesin on genome - lamina interactions is out: Our revised manuscript was parked on the editor/reviewer's desk for 24 weeks, but in the end it got accepted. Sometimes the publishing system does not work so well. .
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Two weeks left to apply for the NKI PhD program! Deadline Sept 30th.
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We wrote a review about sequencing-based techniques for studying DNA double-strand break repair. Free download until 15 Oct:
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