When funding for their current propaganda is withdrawn, @nature et al will pretend they never even heard of the political agenda they are now subserviently pushing.

Huge collaboration indeed. Initially challenging and eventually rewarding. From mundane data processing & curation (by me) to intricate somatic mutational pattern analysis and insightful interpretation (by @emauryg , @seplyarskiy).

Our article in @ScienceMagazine is out, first-authored by somatic mutation extraordinaire @emauryg, @seplyarskiy (Harvard) and me (ex-Sinai). What happens to the DNA in the some human fetal brains? How may that result in mental illness later in life? https://t.co/dnub6AzRXq

Dr Bertagnolli is the new NIH DEIrector. I made a transcript of her 4 min welcome message to the NIH community: …equity…equitable…equitable…diversity…equity…inclusion…accessibility…equity…

There are 4 main types of arguments activists use to undermine the sex binary: 1. Sex expansionism 2. Sex eliminationism 3. Sex as a cluster concept 4. Sex as a multi-level phenomenon Sex expansionists argue that there are more than two sexes, usually based on there being

Conclusion: Chen et al presents evidence that adolescents report improved life satisfaction & mental health within 2 years of GAH unless they died or detransitioned. But the study ignores morbidities and delayed regret. A weak evidence for benefits of GAH /12

Clearly, suicides and detransitions indicate drastic mental health decline, on which the affected subjects did not report. Still, the analysis of Chen et al assumed the missing data on these subjects were statistically no different from those who reported improvement. /11

Interestingly, they also report “Two participants died by suicide[...] and 6 participants withdrew from the study.” First, 2 suicides among only 315 subjects in just 2 years is quite alarming. Second, the 6 withdrawal may mean detransitions. /10

Neither the sophisticated statistical models nor the Discussion of Chen et al address the 2 major limitations I laid out above. /9

Question #2: What biases arise from adolescents self-reporting their mental health? How do we expect them to report anything but improvement after they underwent a difficult social transition & expensive, permanent body modifications? /8

My #1 question: How can a mere 2 year study address delayed onset mental health decline, when the relevant “Swedish study” (PLoS One. 2011; 6(2): e16885), which Chen et al fails to cite, spanned 30 years? /7

Besides self-reported mental health, Chen et al did not address the many known and unknown morbidities of GAH. But what about their claim of mental health benefits after 2 year GAH? /6

Chen et al describes a longitudinal, prospective study on self-reported mental health of adolescents (12-20 yo) after 2 years of GAH. They conclude “GAH improved appearance congruence and psychosocial functioning” /5

Still, no relevant conflict of interest was disclosed from any author. But let’s look at the science. /4

Also notable: 1st author D Chen is affiliated with the Pritzker Dept of Psychiatry and Behav. Health at U Chicago. The Pritzker billionaire family, including trans woman J Pritzker, funds and promotes medical and educational LGBTQ+ programs. /3

I first read the article shortly after its publication since it received broad and even mainstream coverage. Last author Johanna Olson-Kennedy MD disclosed no relevant conflict of interest yet she is director of USC’s pediatric gender clinic that profits from GAH & surgery. /2

Pleased to share the publication of our lipidomic profiling of Chorea-acanthocytosis (ChAc, VPS13A Disease). We found altered levels of sulfatides and other sphingo or phospholipids in brain areas affected by ChAc. https://t.co/QmsFXxSCjO

How to argue for gender affirming care: 1. Silently observe that once "reputable medical & mental health orgs" have been captured by gender ideology. 2. Pretend that those organizations endorsed the affirmative model based on a scientific consensus.

Incredible how scientific fields get polarized and how gender ideology and identity politics are helping the takeover of entire journals or even publishers. Unless Archives of Sexual Behavior pushes back like the NY Times did in a similar case a few months ago.

🧵 I'm tweeting the book I wrote— AUTOHETEROSEXUAL: Attracted to Being the Other Sex It's about the most common kind of trans 🏳️‍⚧️ Let's begin… 1/