Dr Jo Jackson (jojacksonhere.bsky.social)
@jojacksonhere
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Group leader: synapse loss in AD | multi-'omics atlas project https://t.co/w27wMtBT8O | @UKDRI @imperialbrains | love brains, synapses and microscopes | views=mine
Joined December 2010
Our review is out, written by the team @LillyPadEU. Targeting the Synapse in Alzheimer’s Disease
frontiersin.org
Dynamic gain and loss of synapses is fundamental to healthy brain function. While Alzheimer’s Disease (AD) treatment strategies have largely focussed on beta...
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#AAIC25 Come and hear about synaptic proteomic changes over disease progression presented by the amazing Tatiana Georgiades in work funded by @alzheimerssoc
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Super proud of my PhD student, Tatiana, for being chosen as an @ISTAART Ambassador!
Delighted to welcome our new class of ISTAART Ambassadors! This year's 43 Ambassadors represent 27 countries across the globe. They'll work with us at #AAIC25 Toronto / online, and we'll be mentoring them over the next year! Meet them at https://t.co/Pb71EZPMpD!
@alzassociation
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Congratulations to my first Imperial PhD student @Eleonoreschneeg! It's been a pleasure supervising you with @FancyNurun and Paul Matthews. And thanks to the amazing examiners @sj_marzi and @petrouliet. Pretty much an all woman dream team 😍
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Today is the last day to apply for this postdoc position investigating a new chronotherapeutic approach to Alzheimer’s Disease. Please apply on the Imperial website, if interested! @UKDRI @UKDRI_ECR @SRBR_Outreach @EbrsOfficial
New postdoc position available to join our team at Imperial. Please feel free to get in touch if interested! Deadline 10th Feb https://t.co/p6MdYOKplF
@ImperialBrains @UKDRI @SRBR_Outreach @EbrsOfficial
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This opens up new synaptic targets and avenues for the therapeutic targeting of synapses in AD. This was a great team effort by @GriffithsJess94 joint with Seth Grant lab, @Eleonoreschneeg and the UKDRI MAP team. The end. 6/6
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Taken together, we believe we have derived a pseudotemporal profile of synaptic changes in human AD and shown that they are associated with changes in the astrocyte proteome, particularly that of PAPs. 5/6
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Alongside these synaptic changes, we found an astrocyte signature that was enriched for proteins at peri-synaptic astrocytic processes (PAPs). This astrocyte signature increased with pathology and was associated with reduced synaptic resilience. 4/6
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Mitochondrial proteomic changes dominated in the low pathology region, inhibitory changes in the mid pathology region and widespread synaptic transmission pathways were most prominant in the higher pathology region. 3/6
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We showed that there are synaptic proteomic changes in a region of low pathology before synapse loss and that synapse loss and proteomic changes increased in regions with higher pathology. 2/6
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Big week for the Jackson synaptics lab last week... 1st Imperial PhD thesis submitted, presented new data at Japan-UK neuroscience meeting and we have a new preprint out...a 🧵1/6
A synaptic-astrocytic proteomic signature associated with synaptopathy in Alzheimer's Disease https://t.co/cQRVf2lMRg
#biorxiv_neursci
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Pleased to play a small part in this study. Congrats to everyone involved!
13/ Big thank you to all co-authors including @VerenaZuber, @JulienBryois, @prashant1003, @AbouzeidMaya and many many more including important contributions from @DRI; @FancyNurun, @jojacksonhere and @nottalexi to name a few. Study conceived by Michael Johnson @ImperialBrains.
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was great to be interviewed for this book, can't wait to read it! (also nice to see that I've been promoted to Professor (I haven't btw) 🫠)
Featuring lots of interviews with Imperial Professors including @bowelsurgeon @gut_health @Mortdecai @gfrost59 @ProfDavidNutt @DrGaryFuller @jojacksonhere @SanchoShimizu
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*after many unofficial years 🤦🏼♀️
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One official year in (after many official years) of the Jackson lab and celebrated with a 'sip n paint' neon masterclass. Looking forward to the year ahead and pleased to have the best team on board. Watch this space for our synaptic multi-'omics work coming out in 2025
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Was a pleasure to chair the great session today...here's to many more fruitful conversations!
Very excited to be hosting the @EpilepsyInst and @UKDRI research roundtable on Dysregulation of Neuronal Activity in Dementia and Epilepsy today. Thank you to all of the researchers who contributed towards today's fantastic discussions
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Very proud to be working with @alzheimerssoc to fight this devastating disease
Around one million people are living with #DementiaBehindClosedDoors. We can change that when we act as one, loudly telling our stories to make people in power understand why dementia must be a priority. 1/3
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