Jocelyn Kaiser
@jocelynkaiser
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I'm a reporter covering NIH and biomedical research policy for Science magazine.
Joined February 2009
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WOW. Novartis is buying the gene therapy firm AveXis for $8.7 billion. Here's my 2017 story on how their treatment is saving babies with spinal muscular atrophy, a fatal neuromuscular disease.
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The office that polices research fraud in US-funded biomedical labs is in turmoil. Read our scoop
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Shutdown over, but a total of 19 NIH study sections delayed because of Federal Register snafu (backround )
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Why using CRISPR to repair broken genes in sick people won't be easy
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Gene therapy delivered into the blood saves kids with a deadly spinal disease. Next: muscle and brain diseases.
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Shocking, harrowing story of sexual harassment in Antarctica by my colleague
@meredithwadman
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Researchers have homed in on several common genes that may explain why some people become severely ill from covid-19--and that point to possible treatments
@kennethbaillie
@covid19_hgi
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@cristenw
@HeidiRehm
@merrymanlab
@skathire
@JACCJournals
@ACCinTouch
@NEJM
Hey
@ASAPbio_
and other preprint folks:
@nejm
has finally put its policy in writing (see correction notice here )
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Huge news today--first FDA-approved gene therapy for an inherited disease. I profiled the couple behind it back in 2009 (with editor
@laurahelmuth
)
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NIH says its All of Us health study is on track to recruit 1 million volunteers in 5-6 years. The bigger worry: keeping them from dropping out.
#AllofUs
,
@allofusresearch
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My story on Obama precision medicine plan: A genetic biobank on 1 million Americans.
http://t.co/J7Ls5nzdDu
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New data from
#datahound
show ongoing "cull" of NIH PIs
http://t.co/skbiYq1pZ3
http://t.co/VkipfQ06uM
http://t.co/2ZHVvIefoH
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Yesterday in Boston, President Biden spoke of cancer prevention vaccines and blood tests for early cancers. Read more about both here
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A star gene therapy researcher's's dark history of alleged sexual harassment in the lab is revealed in this meticulously reported story by
@meredithwadman
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Good news for AIDS community: Moderna will no longer exclude HIV positive people from its large covid-19 vaccine study. But that's just one company's trial.
Today, we are sharing an important update about our protocol for the Phase 3 COVE Study of mRNA-1273, our vaccine candidate against COVID-19.
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At Senate hearing,
@NIHDirector
just announced that NIH has suspended enrollment in controversial study of moderate alcohol consumption pending investigation. background:
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My story on the odd tale of a woman whose fractured chromosome cured her disease.
http://t.co/Mn0Q4NeBh0
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More than 1400 have signed petition protesting NIH plan to classify basic brain studies as clinical trials
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Because of COVID-19, NIH is urging that all large meeting held at NIH or organized by NIH be held virtually by video or postponed or cancelled. That includes study sections, as first reported by
@MedResJourno
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Scientists and now university groups protest new NIH clinical trials definition Background:
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Stops in September 2022
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Personalized cancer vaccines may help keep melanoma in check and shrink tumors in combo with checkpoint inhibitor.
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Just before covid stopped travel, I met with Costa Rica's rising stars in tropical biology who are coming home to study their country's rich biodiversity.
@AndreaGVincent
#UCR
@ICFJKnight
@PuntoyAparte_1
#ICFJ
@ICFJ
#UCR
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I went to Riyadh to learn how Saudi geneticists are striving to prevent rare diseases in their country. My story:
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Spurred by pandemic, U.S. government will revisit federal policies on risky virus research
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Tom Price, HHS nominee, says he will support science, "make sure factual information is conveyed"
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@BiophysicalFrog
@FORsymp
@NIHDirector
It's the Administrative Procedure Act--applies to HHS agencies but not NSF, apparently. See
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Watching webcast: Risks and Benefits of Gain-of-Function Research: A Symposium:
http://t.co/p6urtCvTr0
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Thanks to
@jorisveltman
and
@dgmacarthur
for their help with my story on human genetics in Saudi Arabia
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Does it matter that 19% of sample so far is from Arizona (2% of US pop) and 59% are women?
#AllOfUS
#allofus
is also well-positioned to examine whether differences in health outcomes reflect variable pathogenesis of disease X by group, or if they are largely driven by failings of the health care system in these communities. The policy implications of this would be massive.
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HHS Sec Price confirms at House hearing that indirect costs are target of Trump NIH budget: "about 30% of grant money" goes to indirects
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Good news for MERS researchers: NIH exempts animal model work from pause on risky virology studies
http://t.co/ZHIrFdUA3C
#GOF
,
#MERS
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Yes it may be. More on study here. and here
Far as I know this if the first large-scale implementation of a "liquid biopsy" screening test that looks for *many* cancers at once.
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An NIH question! Price says he supports efforts to boost funding for Alzheimer's research.
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Yesterday's
#NSABB
meeting: Last October's 1-year "pause" on risky virology studies will now last ~21 months.
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@katewbauer
@JasonSynaptic
@thebyrdlab
@Maratosflier
From my notes from the June 2018 ACD meeting, NIH is hoping to get to 1100 ESIs this year, up from 1040 in 2017 (so not a huge increase)
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Obama's $1B raise for NIH in 2016 boosts BRAIN initiative, Alzheimer's, vaccines, precision med, antibiotics
@ScienceInsider
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"The horror case," says Fineberg: high path, transmissibility in mammals, evasion to countermeasures. Subarrao says regs restrict.
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Two new studies from Reproducibility Project: Cancer Biology reproduced some, but not all original results. 9 (of 29) now out, just 4 fully replicated. background:
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@martinenserink
yes, one newsy tidbit: USG decision on paused studies put off to mid 2016
#NSABB
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Monthly FOIA logs--what a concept! How I wish
@NIH
did this
Things I enjoyed about this Tweet (in no particular order): 1) Wonky reg humor = comic gold; 2) I <3 students using mechanisms of govt transparency; 3) I enjoy discovering new (to me) public universities like
@letsgopeay
; 4) I have an excuse to hum
@SpongeBob
theme
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Senate subcommittee approves $2B increase for NIH in 2018. Details to come.
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NIH has corrected earlier figure--only 16 meetings rescheduled. NIDCD meetings did or will occur on schedule.
Shutdown over, but a total of 19 NIH study sections delayed because of Federal Register snafu (backround )
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Just back from a fantastic week in Costa Rica with
@ICFJKnight
journalism exchange. Many thanks to my excellent host, Silvia from
@PuntoyAparte_1
, and to the many journalists and scientists who met with me.
#ICFJ
@ICFJ
#UCR
#UNA
#ITCR
#SINAC
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Saw that study finding men get $40,000 more for their first NIH grant? We took a closer look.
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Puzzled by slamming of NIH award for oldsters to wind down labs. Isn't idea to make room for young?
http://t.co/VYEBzAMX1c
#emeritusNIHGrant
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NIAID's Kana Subbarao makes plea to lift funding pause for rodent studies and MERS, flu strains that emerged in 2014
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Price: evidence clear that HIV causes aids, abortions do not cause breast cancer. unfamiliar with claim that immigrants spread leprosy
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As expected, Trump 2018 budget plan slashes NIH overhead payments (indirect costs) to 10% (from current 30% avg)
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Doesn't sound too drastic
Does anyone know exactly what "Restructure NIH’s administrative functions to ensure operations are effective and efficient" means in terms of what will happen?
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Subbarao, Michael Imperiale: Need more precise term than "gain of function," which is too broad, covers routine virology studies
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Scientists question the usefulness and validation of a saliva-based genetic test for
#COVID19
severity now sold in the United States.
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That's right--corresponding authors are what bioRxiv gave us. But if you look at coauthors the list would be different--eg 50 for
@dalygene
@ClausWilke
@EricTopol
@jocelynkaiser
@erlichya
I think the article refers to most preprints as corresponding author
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Flu projects in limbo while NIH decides which must stop under gain of function moratorium. See the letters here.
http://t.co/qzbw3YVWM1
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Top U.S. Scientific Misconduct Official Quits in Frustration With Bureaucracy
http://t.co/Ih1ntQtB7y
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It was a delight to meet Evelyn, saved by gene therapy from the disease that took her big sister.
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Yes, NIH says they'll look at intramural too
.
@jocelynkaiser
Will grant limits affect
@IRPatNIH
vs
@NIHgrants
PIs equally? 50% intramural PIs have >$1.2M, yet < 6% extramural PI do.
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