Delighted to share our new paper on 3D imaging of an intact organism via a distributed molecular network, now out in Nature Biotechnology: https://t.co/tbuhxnuoYB https://t.co/95BQtKc8CQ

A 3D map of mRNA transcripts in a zebrafish embryo. This video was not made using a microscope. Researchers tag nucleotides with barcodes, which then "link" together in the tissue. Sequencing those links can then be used to computationally infer the 3D positions of genes.

1. Finer detail – not quite at organism-wide cellular resolution yet, but we’re getting there. 2. Benchmarking gene-enrichments across the organism using spatial array-based datasets. 3. Further development of GSE for embedding 10^7 points/UMIs with research-grade compute.

The paper builds on our earlier preprint: https://t.co/sugUDyoqHa What’s new (highlights):

Postdoc opportunity on 3D spatial proteomics! Tay Lab and Josh Weinstein lab are looking for a joint postdoc to develop this amazing new technology. Position is generously supported by CZ Biohub Chicago, with exceptional pay and benefits: https://t.co/7HNi7bYvUC

Happy to contribute this news & views to @NatComputSci on Kloosterman et al's contribution to a nascent but crucial family of technologies https://t.co/iBH1OZoFvB

@qiannianchao We view this as a fundamental technical and conceptual advance for the DNA microscopy paradigm that, we believe, can powerfully complement other imaging modalities and better probe the spatial-genetic complexity of living systems.

@qiannianchao We deploy a massive intercommunicating network of DNA molecules in a stand-alone chemical reaction to image intact zebrafish embryos (ie "volumetric" DNA microscopy, following on our 2D work https://t.co/DrIBNemmMb).

A new preprint from my lab at UChicago (joint work with @qiannianchao) images 3D specimens from the "inside-out", complete with nucleotide-level genomic detail. https://t.co/dfBwpbXIsK

Very honored to be part of the Moore Inventor Fellow 2020 cohort. Thank you to the Moore Foundation for its strong support of small labs working on big ideas. @MooreFound @UChicagoMed @UChicagoPME

Exploiting the pandemic to wall off the U.S. and dismantle one of our greatest strengths—our ability to attract and retain the brightest minds from around the world—may ultimately cause even more long-term, self-inflicted damage to our country than #COVID19. Abhorrent.

Excited to announce HowWeFeel, an open platform for helping us fight the pandemic. Grateful for collaboration w/ @8en @XihongLin @kinggary @ophirshalem @GreeneScientist @bitdrift @rpjb and many other great colleagues. Visit https://t.co/zgRcHE6D2B. #COVID19Pandemic #coronavirus

This fall, The Weinstein Lab ( https://t.co/3YM2B46jEx) will open at @UChicagoMed and @UChicagoPME. Funded postdoc positions, spirited intellectually-driven research ... all that good stuff. Please spread the word (and shoot me a message if you're interested).

HHMI News: "DNA microscopy" offers an entirely new way to image cells.

Joshua Weinstein @jaweinst explains the magic of DNA microscopy: optics-free spatio-genetic imaging by a stand-alone chemical reaction. It's just math folks! Today's cover @CellPressNews: https://t.co/jGFYRNkQtv https://t.co/ZQAVHUk3ZJ MIA @broadinstitute https://t.co/jWcakJ5b3I

DNA microscopy works a bit like your cellphone service, using triangulation to map the exact location of molecules within a cell

DNA microscopy (imaging from the cell’s view of the world). Delighted to have the first paper published in Cell. https://t.co/d8f5L3Npaa

DNA microscopy: Optics-free spatio-genetic imaging by a stand-alone chemical reaction https://t.co/T0WlXUPRrN #bioRxiv