Delighted to share our new paper on 3D imaging of an intact organism via a distributed molecular network, now out in Nature Biotechnology:.

RT @NikoMcCarty: A 3D map of mRNA transcripts in a zebrafish embryo. This video was not made using a microscope. Researchers tag nucleoti….

What do you want to know?.

1. Finer detail – not quite at organism-wide cellular resolution yet, but we’re getting there. 2. Benchmarking gene-enrichments across the organism using spatial array-based datasets. 3. Further development of GSE for embedding 10^7 points/UMIs with research-grade compute.

The paper builds on our earlier preprint: What’s new (highlights):

RT @SavasTay_UChi: Postdoc opportunity on 3D spatial proteomics! Tay Lab and Josh Weinstein lab are looking for a joint postdoc to develop….

Happy to contribute this news & views to @NatComputSci on Kloosterman et al's contribution to a nascent but crucial family of technologies.

@qiannianchao We view this as a fundamental technical and conceptual advance for the DNA microscopy paradigm that, we believe, can powerfully complement other imaging modalities and better probe the spatial-genetic complexity of living systems.

@qiannianchao We deploy a massive intercommunicating network of DNA molecules in a stand-alone chemical reaction to image intact zebrafish embryos (ie "volumetric" DNA microscopy, following on our 2D work .

A new preprint from my lab at UChicago (joint work with @qiannianchao) images 3D specimens from the "inside-out", complete with nucleotide-level genomic detail.

Very honored to be part of the Moore Inventor Fellow 2020 cohort. Thank you to the Moore Foundation for its strong support of small labs working on big ideas. @MooreFound @UChicagoMed @UChicagoPME.

RT @davidrliu: Exploiting the pandemic to wall off the U.S. and dismantle one of our greatest strengths—our ability to attract and retain t….

RT @zhangf: Excited to announce HowWeFeel, an open platform for helping us fight the pandemic. Grateful for collaboration w/ @8en @XihongLi….

This fall, The Weinstein Lab ( will open at @UChicagoMed and @UChicagoPME. Funded postdoc positions, spirited intellectually-driven research . all that good stuff. Please spread the word (and shoot me a message if you're interested).

RT @HHMINEWS: HHMI News: "DNA microscopy" offers an entirely new way to image cells.

RT @jbloom22: Joshua Weinstein @jaweinst explains the magic of DNA microscopy: optics-free spatio-genetic imaging by a stand-alone chemical….

RT @NYTScience: DNA microscopy works a bit like your cellphone service, using triangulation to map the exact location of molecules within a….

DNA microscopy (imaging from the cell’s view of the world). Delighted to have the first paper published in Cell.

RT @biorxivpreprint: DNA microscopy: Optics-free spatio-genetic imaging by a stand-alone chemical reaction #bioRxiv.