Jason Zhaoxing Zhang
@jasonzxzhang
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Molecular tool designer for intracellular signaling at @UWproteindesign | PhD @jinzhanglab @UCSanDiego l BS @UCBerkeley. 🏳️🌈🇺🇸 BlueSky: @jasonzxzhang
Seattle, WA
Joined July 2020
I am transitioning my social media presence from here to Bluesky. For me, Twitter is no longer a reliable source of information and I vehemently despise Elon. If you want to be up to date with what I do, then feel free to add me on Bluesky:
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RT @CellPressNews: Online now! De novo designed Hsp70 activator dissolves intracellular condensates. Check out the study by chemistry laure….
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Excited to share my recent work on designing new Hsp70 activators to regulate condensates, and thus reveal their functions: @UWproteindesign.
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Just started my BlueSky account: Feel free to add me there as well! Will see how this goes 🤔.
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This is an honor well deserved! I am always amazed by the sheer ingenuity David and our lab always produces. Congratulations to David! @UWproteindesign.
BREAKING NEWS.The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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RT @sigalalab: Fantastic first day of science with our Postdoc Rising Stars and amazing keynote by @TheVillaLab on jumbo phages!@UofUBioche….
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Excited to visit @UUtah! I really appreciate the opportunity to share my recent work @sigalalab @Myers_lab 🙏🏼!.
We're excited to announce the upcoming Postdoctoral Rising Stars Symposium @UofUHealth with 20 outstanding scientists from broad backgrounds and keynote by @TheVillaLab, with generous support by @BWFUND. Hosts @UofUBiochem @uofunuip @UUNeurobiology @uofupharmacy @huntsmancancer
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Thrilled to share progress on Ras isoform binders! Using AI-driven protein design, I’ve targeted the challenging, highly charged and disordered C-terminus of Ras. These de novo binders exceed antibody specificity and effectively disrupt Ras signaling.
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Recently out at Nat Chem Bio! I used my Ras biosensors (Zhang et al Nat Biotech 2024) to profile the activity and environment of Ras at the single-cell level, which unveiled the signaling mechanisms underlying RasG12C inhibitor resistance. @UWproteindesign.
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Excited to share that my K99 at NCI is awarded! I will continue to build new protein tools to understand the signaling programs enabling Ras drug resistance. And with that, a shameless plug that I’m on the faculty market this Fall 2024 👀.
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The future faculty page of Baker lab postdocs is now online! Please check out the cool things my colleagues and I are doing and plan to do!.
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RT @GoogleDeepMind: Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molec….
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NCI blog post about my de novo designed Ras biosensors:
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Happy to share that the Ras sensors (Ras-LOCKR-S and Ras-LOCKR-PL) are now on Addgene!
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