Jason Zhaoxing Zhang
@jasonzxzhang
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Molecular tool designer for signaling | Assistant Professor at @UCLA | 🏳️🌈🇺🇸 not on Twitter, on BlueSky: https://t.co/eaiMcFDhE1
Seattle, WA
Joined July 2020
I am transitioning my social media presence from here to Bluesky. For me, Twitter is no longer a reliable source of information and I vehemently despise Elon. If you want to be up to date with what I do, then feel free to add me on Bluesky:
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Online now! De novo designed Hsp70 activator dissolves intracellular condensates. Check out the study by chemistry laureate @Uwproteindesign David Baker, @jasonzxzhang & others in @CellChemBiol #bps2025
cell.com
Zhang et al. describe computationally designed proteins that modulate Hsp70 ATPase activity. One of these designs refolds proteins, dissolves intracellular condensates, and uncovers their cellular...
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Excited to share my recent work on designing new Hsp70 activators to regulate condensates, and thus reveal their functions: https://t.co/kkg6Ww1KvC
@UWproteindesign
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Just started my BlueSky account: https://t.co/mPjwgDOO3M Feel free to add me there as well! Will see how this goes 🤔
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This is an honor well deserved! I am always amazed by the sheer ingenuity David and our lab always produces. Congratulations to David! @UWproteindesign
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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Fantastic first day of science with our Postdoc Rising Stars and amazing keynote by @TheVillaLab on jumbo phages!@UofUBiochem @uofunuip @huntsmancancer @uofupharmacy @BWFUND
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Excited to visit @UUtah! I really appreciate the opportunity to share my recent work @sigalalab @Myers_lab 🙏🏼!
We're excited to announce the upcoming Postdoctoral Rising Stars Symposium @UofUHealth with 20 outstanding scientists from broad backgrounds and keynote by @TheVillaLab, with generous support by @BWFUND. Hosts @UofUBiochem @uofunuip @UUNeurobiology @uofupharmacy @huntsmancancer
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Thrilled to share progress on Ras isoform binders! Using AI-driven protein design, I’ve targeted the challenging, highly charged and disordered C-terminus of Ras. These de novo binders exceed antibody specificity and effectively disrupt Ras signaling. https://t.co/uezpEHhm5b
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Recently out at Nat Chem Bio! I used my Ras biosensors (Zhang et al Nat Biotech 2024) to profile the activity and environment of Ras at the single-cell level, which unveiled the signaling mechanisms underlying RasG12C inhibitor resistance. https://t.co/jWRLxFM4xm
@UWproteindesign
nature.com
Nature Chemical Biology - Profiling endogenous Ras (rat sarcoma virus) activity during Ras-G12C inhibition at the single-cell level revealed signaling and metabolic changes driven by wild-type Ras...
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Excited to share that my K99 at NCI is awarded! I will continue to build new protein tools to understand the signaling programs enabling Ras drug resistance. And with that, a shameless plug that I’m on the faculty market this Fall 2024 👀.
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The future faculty page of Baker lab postdocs is now online! https://t.co/kzgGAyN1Yg Please check out the cool things my colleagues and I are doing and plan to do!
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Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules. 🧬 Here’s how we built it with @IsomorphicLabs and what it means for biology. 🧵 https://t.co/K7uxMxdNr8
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Happy to share that the Ras sensors (Ras-LOCKR-S and Ras-LOCKR-PL) are now on Addgene!
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Protein structure design is here! Hope our recent work ( https://t.co/r7n2oG622T) on de novo design of protein sensors will be interesting and relevant to others curious in functional protein design.
nature.com
Nature Biotechnology - Computationally designed sensors map the activity and signaling environment of Ras.
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