Manish Jain
@jainmk6
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Biochemist, Pharmacologist, Structural biologist University of North Carolina at Chapel Hill
Chapel Hill, NC, USA
Joined August 2019
RT @zenbrainest: More Than Serotonin: How Psychedelics Engage the Whole Brain.#psychedelics.
neurosciencenews.com
Neuroscience News research articles cover neurology, psychology, AI, brain science, mental health, robotics and cognitive sciences in a free, open access magazine.
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More Than Serotonin: How Psychedelics Engage the Whole Brain - Neuroscience News
neurosciencenews.com
Neuroscience News research articles cover neurology, psychology, AI, brain science, mental health, robotics and cognitive sciences in a free, open access magazine.
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RT @johnthefryer: Hugely important work from @zenbrainest that opens new doors (and immensely complicates the picture!) The polypharmacol….
cell.com
Jain et al. profiled 41 classical psychedelics across 318 GPCRs, revealing activity at serotonin, dopamine, and adrenergic receptors. All compounds activated multiple 5-HT2AR signal transduction...
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RT @rgumpper: It's finally out! Our "somewhat" thorough study on psychedelic polypharmacology. Congrats to @jainmk6 @zenbrainest and everyo….
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RT @zenbrainest: EVERYTHING YOU EVER WANTED TO KNOW ABOUT #PSYCHEDELICS AND THINGS YOU NEVER THOUGHT ABOUT!.https:/….
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I am excited to share our latest work in @Neuron exploring the pharmacology of psychedelics. I am deeply grateful to my PI, Prof. Bryan Roth, @zenbrainest, for his exceptional guidance, and to all my co-authors for their valuable collaborations.
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RT @THebertMcGill: Molecular glues becoming a thing in the GPCR world!.
nature.com
Cell Research - Orchestrating NTSR1 signaling from the interface
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Happy to share another article on selective non-catechol agonists for D1R! Functionally Selective Dopamine D1 Receptor Endocytosis and Signaling by Catechol and Noncatechol Agonists | Biochemistry
pubs.acs.org
The dopamine D1 receptor (D1R) has fundamental roles in voluntary movement and memory and is a validated drug target for neurodegenerative and neuropsychiatric disorders. However, previously develo...
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#psychedelics! Excellent piece of work on psychedelics explaining their molecular details of binding to 5HT2A receptor. Also this is my first co-first author paper from the Roth lab. Congratulations @rgumpper @RothLabUNC!
nature.com
Nature Communications - The authors present 7 cryo-EM structures of hallucinogenic and non-hallucinogenic compounds across multiple chemotypes bound to the 5-HT2A receptor, shedding light onto...
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RT @rgumpper: Happy to share that this work on the structural biology of #psychedelics is finally out! Big shout out to all involved, espec….
nature.com
Nature Communications - The authors present 7 cryo-EM structures of hallucinogenic and non-hallucinogenic compounds across multiple chemotypes bound to the 5-HT2A receptor, shedding light onto...
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RT @CanCao_Natural: Super cool study on psychedelic's action on 5-HT2A. Congrats! @rgumpper @zenbrainest and @ Manish.
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RT @zenbrainest: Yuuge paper on #psychedelics The structural diversity of psychedelic drug actions revealed
nature.com
Nature Communications - The authors present 7 cryo-EM structures of hallucinogenic and non-hallucinogenic compounds across multiple chemotypes bound to the 5-HT2A receptor, shedding light onto...
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RT @rgumpper: Our perspective on this emerging outlook on GPCR allosteric modulators that facilitate protein-protein interactions is out no….
pubs.acs.org
G-protein-coupled receptors (GPCRs) transmit an extracellular chemical/biological signal across the cell membrane, stimulating an array of intracellular signaling cascades. Canonically, these...
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RT @HarvardCCB: Congratulations to @zenbrainest of @UNC_PHCO for delivering a great Frank H. Westheimer Prize Lecture this afternoon at @H….
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