Ryan Gumpper
@rgumpper
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Assistant Professor at UNC Chapel Hill, GPCRs, Structural Biology, Musician
Chapel Hill, NC
Joined March 2010
UNC Neurobiology Students Explore CryoEM Technology in Hands-On Structural Biology Session https://t.co/FtKb6UeE6G
@JoshuaStrauss5 @anowlan @rgumpper @UNC_PHCO @unc_our
med.unc.edu
On October 13, 2025, over sixty undergraduate neurobiology students visited the cryoEM core as part of their NSCI 405: Advanced Molecular Neuropharmacology course. The visit was organized by Dr....
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I’m thrilled to share our latest work in Cell! We developed a GoA pathway–selective 5-HT1AR agonist that may achieve rapid antidepressant effects by bypassing DRN autoreceptor feedback. Huge thanks to my amazing team and collaborators!
cell.com
Structural and functional analyses of a brain-enriched serotonin receptor, 5-HT1AR, elucidate the molecular basis of Gi/o subtype selectivity, leading to the design of a GoA-preferential agonist that...
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Hooray!! The first major product from the lab is out today @Nature. Small molecules that bind the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design.💥 Check it out! 👉 https://t.co/oO21BkoxVQ 🧵👇
nature.com
Nature - Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching...
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AlphaFoldDB updated, now includes the MSAs 🥳
We’re renewing our collaboration with @GoogleDeepMind! We'll keep developing the AlphaFold Database to support protein science worldwide 🎉 To mark the moment we’ve synchronised the database with UniProtKB release 2025_03 https://t.co/VTzPuEUC1r
#AlphaFold
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BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2025 #NobelPrize in Chemistry to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.”
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BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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New preprint - basically we noticed that by applying ab initio (SDG) at high res in CS, using a very small step size, we could crack some small proteins we hadn't been able to solve before. Read the preprint or head over to bluesky for a longer thread! https://t.co/aTe4bNxmuf
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Delighted to share our latest study on a nanobody-based sensor of GPCR activation and signaling! A genetically encoded nanobody sensor reveals conformational diversity in β-arrestins orchestrated by distinct seven transmembrane receptors | PNAS
pnas.org
Agonist-induced interaction of G protein–coupled receptors (GPCRs) with β-arrestins (βarrs) is a critical mechanism that regulates the spatiotempor...
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A NOA from NIDA on a UG3 grant is here. Excited to work with Brian Kobilka and Jay Mclaughlin on NAMs for treating opioid overdose upto IND phase. Several postdoc positions in both chemistry/pharmacology available. @washumedicine @WashUClinPharm Please RT
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Hugely important work from @zenbrainest that opens new doors (and immensely complicates the picture!) The polypharmacology of psychedelics reveals multiple targets for potential therapeutics: Neuron
cell.com
Jain et al. profiled 41 classical psychedelics across 318 GPCRs, revealing activity at serotonin, dopamine, and adrenergic receptors. All compounds activated multiple 5-HT2AR signal transduction...
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It's finally out! Our "somewhat" thorough study on psychedelic polypharmacology. Congrats to @jainmk6 @zenbrainest and everyone else involved! https://t.co/9dIzRXs2ry
#psychedelics
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EVERYTHING YOU EVER WANTED TO KNOW ABOUT #PSYCHEDELICS AND THINGS YOU NEVER THOUGHT ABOUT! https://t.co/2RDpHGPxOe
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I am excited to share our latest work in @Neuron exploring the pharmacology of psychedelics. I am deeply grateful to my PI, Prof. Bryan Roth, @zenbrainest, for his exceptional guidance, and to all my co-authors for their valuable collaborations.
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Online now! Structures of USP7 in active and inactive states bound to DNMT1 revealed by cryo-EM
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New online! RNA polymerase II transcription compartments — from factories to condensates https://t.co/Vd03V74R2B
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a serotonin transporter that inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin
cell.com
Serotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell...
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“What are the potencies, efficacies and signaling properties I would like to optimize to create psychedelic-like drugs which are therapeutic and are not psychedelic?” #psychedelic
https://t.co/yhHMkefFR2
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Inspired by @mbeisen I've begun an experiment in open science. We are sharing our ongoing work on psychedelic signaling here: https://t.co/YQ16iIb2Vo I've decided to make this 'open' as the experiment are of immediate interest to the field and I'll write them up later.
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