Seb
@ibdseb
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IBD clinician& researcher @IBDHull. Governing Board :ECCO own views, RT🚫endorse.⚽️@LFC fan.
England
Joined August 2010
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Preclinical #IBD can be detected, and has stages. FCP >225 in a first degree relative appears to be a later stage. Stage 3-4 preclinical Type 1 DM can be treated with teplizumab resulting in significant delay (4y+) or prevention of insulin dependence. https://t.co/7HGjj58hA9
pubmed.ncbi.nlm.nih.gov
Approximately one in five asymptomatic FDRs had persistently elevated calprotectin, which was able to differentiate those with presymptomatic CD. The findings highlight calprotectin's utility in...
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Very happy with our new publication! Thank you to all brazilian and international contributors @PortalSBCP @SBCProcto @nlavellaneda @jcpatron @DrMelissavega @SurgJournal @SWexner
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"Imagine you are hiking around in the Swedish mountains. You are in a valley and you want to come out of this valley. You cannot tunnel through it; you have to hike above the peak. In the world of superconducting microscopic phenomena, this is not quite the case, and the
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"In many countries, health is no longer seen as a social good, but more as a profit-driven industry." Read part 2 of Richard Horton's Offline 'Watching the watchers':
thelancet.com
The chief threat to health systems, according to Global Health Watch 7 (GHW7), comes from privatisation, financialisation, and corporatisation, trends that have only accelerated in recent decades,...
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First contact with the UEG Council 2026 today! So proud to be part of @my_ueg, expecting to learn and work a lot in the following years #WeAreUEG @Iagorlago
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🌍Welcome to our webinar on the Best of UEGW 2025 in IBD !!! Tuesday 16. December 4 pm 🇳🇴 🇪🇸 Speakers: @dr_luisa_bertin 🇮🇹🇧🇷y @Efuentesval 🇪🇸🇨🇱 Join us!!! @YOGI_IBD
@geteccu @ACTECCU @gadeccu @GECCOL1 @sepdigestiva
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@ibdseb @jalpa_devi @NMH_SHanauerMD @AIBDNetwork @DCharabaty @DrCoreySiegel @clivejmiranda @UNMC_GIHEP @MLongMD @MRegueiroMD @KrugCleveland @MayoClinicGIHep @IBD_Houston @P_DeepakIBDMD @IBD_Afzali @MondayNightIBD @ibdtweets @Bealoquebea I understand—the “low hanging fruit” is the patient who feels well but has endoscopic inflammation—easier to justify intensification in these. But the evidence for histologic healing is accumulating…
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This 👇 💯 Need selfless leadership from consultants and professional bodies to ensure this 🤔
Rather than a binary choice between @NHSuk consultants doing everything and replacing doctors with other healthcare professionals, we should reimagine the firm for the 21st century. That means team based hospital medicine with clear medical leadership and continuity
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@NMH_SHanauerMD @AIBDNetwork @DCharabaty @DrCoreySiegel @clivejmiranda @UNMC_GIHEP @MLongMD @MRegueiroMD Smoldering UC by @EdwardLoftus2 @AIBDNetwork #AIBD2025 ☣️ careful use of steroids 💱 Discrepancy 💩 vs 🔦 🔬 Histological remission matters! 🎬BOTTOM LINE: Treat Smoldering inflammation!!
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@NMH_SHanauerMD @AIBDNetwork @DCharabaty @DrCoreySiegel @clivejmiranda @UNMC_GIHEP @MLongMD @MRegueiroMD @EdwardLoftus2 @KrugCleveland @MayoClinicGIHep @IBD_Houston @P_DeepakIBDMD @IBD_Afzali @MondayNightIBD @ibdtweets @ibdseb @Bealoquebea 🔎Surveillance for the Longstanding UC Patient! @NayantaraCoelho hd-WLE=hd-Dye CE= Virtual CE
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💡Have you heard about @YOGI_IBD ? 🌍 We are the first global network for young GIs interested in IBD from all over the world In this video my co-founder @DCharabaty and myself share an update for 2025/2026 Join us! https://t.co/qY0yNOqWGI Thanks!!!
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Prime Editing for p47phox-Deficient Chronic Granulomatous Disease | New England Journal of Medicine
nejm.org
Chronic granulomatous disease (CGD) is a severe monogenic immunodeficiency caused by damaging variants in genes required for microbicidal NADPH oxidase activity. Autosomal recessive p47phox-deficie...
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Was great speaking at IBD Summit Madrid on techniques & pathways conventional med can learn from 'complementary med', and also at @naturcyte symposium on the fascinating AhR pathway: linking diet, microbiome and IBD (and also the target of #CurQD). But still much to learn
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Thank you 🙏🏼 Amelia - really useful . Like the visual atlas
Very excited to share our visual atlas for Monitoring Postoperative Crohn’s Disease with IUS- incredible work led by @DrPhil_Gu and @iUSCAN research committee!
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Great paper 👏👏and again highlights the need to ensure good disease control to reduce CRC risk . Apart from 5ASAs I feel agents don’t matter but disease control is what is important Also wonder whether the MH means stop or reduce frequency further for surveillance 🤔
📣chemoprevention in inflammatory bowel disease. In the absence of RCT data➡️50 observational studies: 1.4 million patients: Anti-TNFs⬇️colorectal cancer (CRC) risk in ulcerative colitis (UC) & 5-ASAs⬇️CRC risk in UC and Crohn’s disease 👇🏽@ahkefayat @EdinUni_IGC 🙏🏽to all authors
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📣chemoprevention in inflammatory bowel disease. In the absence of RCT data➡️50 observational studies: 1.4 million patients: Anti-TNFs⬇️colorectal cancer (CRC) risk in ulcerative colitis (UC) & 5-ASAs⬇️CRC risk in UC and Crohn’s disease 👇🏽@ahkefayat @EdinUni_IGC 🙏🏽to all authors
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Those who are interested in neutrophil biology 🧪 in disease including #IBD this 👇 is a nice resource
nature.com
Nature - Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state...
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💯 Relevant in all health care systems
PSA to primary care providers: People do NOT need to have screening colonoscopy just because they have a colon. Consider: ☑️Age ☑️Life expectancy ☑️Overall health ☑️ Ability to take a prep There are nuances and then there is the completely obvious...
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PSA to primary care providers: People do NOT need to have screening colonoscopy just because they have a colon. Consider: ☑️Age ☑️Life expectancy ☑️Overall health ☑️ Ability to take a prep There are nuances and then there is the completely obvious...
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Extremely happy to share that I was awarded "Best DM thesis award" at #ISGCON2025 Amritsar. Sincere thanks to my guide Prof. Ebby Simon at @OffCMCVellore for supporting me through out this journey. Icing on the cake is receiving @IJG_Journal Reviewer Appreciation Award
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