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Alpha Lee Profile
Alpha Lee

@iamalphalee

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257
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192

Drug discovery @PostEra_AI. Faculty member @Cambridge_Uni. Breaking viruses @asap_discovery. Views are my own.

Joined January 2020
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@iamalphalee
Alpha Lee
10 months
We have an internal pipeline on Women's Health and reproductive endocrinology, and multiple big pharma partnerships. As a young company these deals have driven $50M in revenue and today we're profitable as a result.
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@iamalphalee
Alpha Lee
10 months
This expanded collaboration spotlights the versatility and validation of Proton, our drug discovery platform. Personally, I'm excited by the growth of PostEra from pioneering AI research in medicinal chemistry to a TechBio...
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@iamalphalee
Alpha Lee
10 months
Delighted to share the double-expansion of our collaboration with @pfizer , expanding on AI-driven small molecule drug design as well as broadening into payload design for Antibody-Drug Conjugates (ADCs)... ➡ Endpoints News Story:
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endpoints.news
Pfizer has re-upped its drug discovery deal with AI startup PostEra to develop small molecule drugs and new warheads for antibody-drug conjugates, a major area of focus for the drugmaker ...
@PostEra_AI
PostEra
10 months
#NEWS: Today we're excited to announce a double-expansion of our collaboration with @pfizer. We'll be expanding our existing AI Lab partnership, while also launching a new partnership to develop novel payloads for Antibody-Drug-Conjugates (ADCs)...
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@garrytan
Garry Tan
2 years
Jesus said to her, "I am the resurrection and the life. The one who believes in me will live, even though they die; and whoever lives by believing in me will never die. Do you believe this?” John 11:25 He is risen
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@schwabpa
Patrick Schwab
2 years
I would not recommend to make the below your mantra for AI in drug discovery. - Metadata is key - no amount or mixture of data without enough information about the context in which the data were generated will give you generalizable insights, nor will you have any hope to
@maxjaderberg
Max Jaderberg
2 years
From everything I see day to day, deep learning for drug design has exactly the same characteristics as other DL-successful domains: - dataset design and mixture is key - scalable and stable architectures and losses trump all - end-to-end is better, just follow the gradient
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@KRHornberger
Keith Hornberger
2 years
If you need a reminder that static protein structures aren’t ground truth, here you go. Does a great job highlighting some challenges any AI/ML drug discovery approach is going to face. h/t @pwk2013 for sending my way https://t.co/N8PQwlVw68
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@KRHornberger
Keith Hornberger
2 years
Sweet baby Jesus. Several others have pointed this out now, but here’s an apparently peer-reviewed article full of AI-generated gibberish images. I can’t even find it in myself to laugh because this is a reprehensible breakdown at every possible level. 🤦‍♂️ https://t.co/v3LGgd97Kl
frontiersin.org
This manuscript comprehensively reviews the interrelationship between spermatogonial stem cells (SSCs) and the JAK/STAT signaling pathway. Spermatogonial ste...
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@garrytan
Garry Tan
2 years
Hope we all get rich together 恭喜发财 Gong xi fa cai 🧧 Happy New Year!
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@ShengwuLi
Shengwu Li
2 years
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@PostEra_AI
PostEra
2 years
📢Today marks a significant milestone as we announce our new #AI collaboration with Amgen! Alongside our existing collaborations with Pfizer and the NIH, this collaboration will go such a long way in helping us advance drug discovery and bring more cures to patients.
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@iamalphalee
Alpha Lee
2 years
Subsequent to the work described in the paper, we nominated a preclinical candidate, now undergoing IND-enabling studies by @DNDi. We also launched @asap_discovery to expand the vision, with funding from NIAID to work on picornavirus, flavivirus and broad spectrum CoV.
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@iamalphalee
Alpha Lee
2 years
Our journey towards a COVID antiviral - from crowdsourcing to delivering robust leads with machine learning-driven med chem - is published in @ScienceMagazine! An exhilarating global effort involving 200+ scientists: https://t.co/a53Io9M7La
@covid_moonshot
COVID Moonshot
2 years
The COVID Moonshot project has just been published in @ScienceMagazine! Take a read of our journey to develop patent free COVID antivirals. 🧵... Read the full article ➡️ https://t.co/WlDUHVg6r8 #AI #OpenScience #Covid
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@NAChristakis
Nicholas A. Christakis
2 years
Princeton undergrad says the quiet part out loud: we are not here to learn; we are focused on extracurriculars and activism; and we don’t want to spend time studying. Why go to *Princeton* then?! “Further, classes are known for assigning 200 or more pages of reading each week
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@jrib_
Janosh
2 years
Matbench Discovery just hit v1 on arXiv and PyPI! 🎉 1️⃣ TL;DR We built a way to test how well ML models can predict stable crystals to accelerate materials discovery. 🧪 ML has come a long way since @ChrisJBartel et al. 2020 https://t.co/SlLGUHTH5p
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@garrytan
Garry Tan
2 years
Startups are incredibly binary and compounding is powerful. Many successful leaders run out of juice after their first mega exit. It takes incredible amount of intrinsic motivation to keep stewarding new ventures well after it makes purely economic sense to do so.
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@CranfordMATTER
Steve Cranford
2 years
OK, can we PLEASE stop including these kind of figures in EVERY ML/AI materials paper... we don't need the "blocks with arrows" diagram anymore... unless there is something new/novel/innovative/critical in the figure, drop it.
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@garrytan
Garry Tan
2 years
Bring back standardized tests Merit is good
@LHSummers
Lawrence H. Summers
2 years
My alma mater, @MIT, which did the right thing years ago on legacy has been right also in reinstating standardized testing requirements.
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@AjitPai
Ajit Pai
2 years
#SCOTUS: @Harvard/@UNC admissions programs violate the Equal Protection Clause. Universities "have concluded, wrongly, that the touchstone of an individual’s identity is not challenges bested, skills built, or lessons learned but the color of their skin." https://t.co/2PZY8zn34V
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@garrytan
Garry Tan
2 years
Just overheard a college-age job candidate regurgitating de-growth points about how neoliberalism is ruining the Earth in a job interview YIKES If young people don't believe a better world is possible through innovation and business, society is screwed.
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