DOM Research day with amazing science, trainees and energy! And to top it all, ROC! @PittVMI @PittDeptofMed @PittTweet.

So excited to present at the MGR today!! How can we understand biological aging? Looking forward to seeing you at LHAS at noon.

RT @PittDeptofMed: A reminder to join us at noon TODAY, 03.04.25, for the DOM Grand Rounds!. Today's MGR, "Can we measure and intervene wit….

@AgingPitt @PittVMI @PittGeriMed @PittDeptofMed.

Such a fun project and think outside the box collaboration with Drs. Steinhauser and Okawa!! Looking forward to digging deeper.

We propose that such large-cluster gene silencing may act as both, a candidate driver and marker of the senescence state.

We provide insight into how senescence-inducing stimuli affect the large-cluster gene expression landscape and offers a plausible rationale for both-molecular heterogeneity of senescence, as well as the challenge in defining universal senescence markers.

Using several senescence models, we observed a greater frequency of cells meeting this high threshold of geographically concentrated transcriptional repression relative to respective control cells.

Interestingly, performing single cell RNA seq analysis we observed a higher frequency of geographically clustered gene repression across somatic chromosomes in clusters that emerge after senescence stress stimulus.

Given the spatial dimensions of the observed DNA dense and transcriptionally silent globules we reasoned that associated transcriptional effects operate on a scale larger than any individual gene—that is, repression of chromosomal segments.

We applied multi-isotope imaging mass spectrometry (MIMS)-method of nanoscale quantitative imaging of stable isotope tracers, to quantitatively map newly synthesized RNA in senescent cells. We identified hypercondensed, transcriptionally silent DNA globules in senescence.

Check out our latest: Senescence is a cell fate decision and a hallmark of aging. Senotypes- broad range and heterogeneity of senescence phenotypes- requires the integration of multi-modality single cell analytic tools to better define senescence.

Looking forward to serve in this role and build our community. Thank you @PittDeptofMed @AgingPitt @PittGeriMed.

RT @PittDeptofMed: Congratulations to Aditi Gurkar, PhD, who has been appointed as the new Associate Vice Chair for Academic Advancement in….

Thank you @OptispanPodcast @optispan for having me on the podcast. Loved discussing all things senescence, DNA damage and aging. Such a great time to be in the field of aging biology. Join us! @AgingPitt @PittVMI @PittDeptofMed @PittGeriMed.

Let's talk about Healthy Aging. So much to do in this growing field. AGE has been on my mind lately, since we are almost at the end of my birthday month! @NIHAging @BuckInstitute @scifri @Radiolab.

So this is happening today! Very excited to be part of @scifri and talk about biological age! @AgingPitt @PittGeriMed @PittVMI @PittDeptofMed @americanaging @AFARorg @hevolution_f @OptispanPodcast.

Congratulations to Dr. Angeli! Join our community- interact with amazing mentors!.

Some of our recent work covered this weekend. Excited to continue on this journey to examine what drives biological age and can we fingerprint it. Thank you to all the collaborators; @shruthi262 who led this amazing project!

So excited to have Dr. Zoncu here at Pitt tomorrow telling us all about the lysosomes! Come down and see him in-person at Bridgeside!! @PittGeriMed @AgingPitt @UPMCHillmanCC @PittVMI.