Graham Erwin
@grahamserwin
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Asst. Professor @bcmhouston. Previously Stanford and UW–Madison. We use molecules and genomes to understand repetitive DNA sequences. #FirstGenAcademic
Houston, TX
Joined September 2014
I am delighted to announce that I recently joined the Department of Molecular and Human Genetics at Baylor College of Medicine. We investigate the functional role of repetitive DNA with a focus on translating discoveries to improve human health. Interested in joining and can't
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Come check out Cera’s poster (4106) today at 2:30pm! Pre-print:
medrxiv.org
Long-read sequencing provides a more complete view of the genome than short-read sequencing, with advantages in the detection of structural variants, tandem repeats, and small variants (single...
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ASHG25 Poster 4106 Today at 2:30pm! Whole-genome long-read sequencing from just j10 NANOGRAMS! ULI-HiFi delivers: ✅ 99.82% F1 for SNVs ✅ 98.9% TR accuracy ✅ Discovered LIMD1 TR expansion progressively increasing from normal→polyp→adenocarcinoma
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Google invented the Transformer and employed every AI pioneer that matters. They even had ChatGPT-level tech ready in 2021. Yet OpenAI's launch caught them "completely flat-footed." How the greatest business in history wound up playing catch-up 👇 @AcquiredFM
Live!
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@grahamserwin lab, Dr. Brendan Lee and Dr. Christine Eng at the @bcmgenetics @BaylorGenetics #ASHG25 Kick off party.
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At ASHG25 RIGHT NOW! Deep-coverage PacBio HiFi sequencing reveals hotspots of tandem repeat variation in the male germline. 12 men, paired blood/sperm, 1.7M repeats analyzed. What we found about mutational bias will surprise you! Lucas Finot's Poster 6044W, 2:30-4:30pm today.
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Proud to announce that we received the NIH Director's New Innovator Award to develop a new class of genome editing tools!
Dr. @grahamserwin receives NIH New Innovator Award! https://t.co/SMTmjK47IP
@bcmhouston @bcmgenetics @BCMCancerCenter
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Dr. @grahamserwin receives NIH New Innovator Award! https://t.co/SMTmjK47IP
@bcmhouston @bcmgenetics @BCMCancerCenter
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I started using Kudos in 2023, and it keeps getting better.
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Interested in modern grant writing in the age of AI? Join us this summer through Stanford Continuing Studies!
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I had such a powerful experience at BCM SKY Retreat this weekend led by @grahamserwin and met so many amazing people! It was a thought-provoking and reflective weekend with lessons that I will carry with me! What a privilege to partake in such a transformative experience! 🥰
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AI for grant writing: The SBIR grant deadline to apply for grants is June 5th, so we have organized a webinar by Nextthought on Monday, May 19th from 5-6pm PT. Join to learn how to get your grant written fast. https://t.co/E9cQaxSPQ7
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Due to NIH cuts I’m on the job market. Computational biologist, data scientist, human geneticist targeting industry in Seattle or remote. Python, R, SQL, Linux cluster computing, command line, data viz plus deep genetics and bio expertise. PhD from Columbia University. Please RT!
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Already 30+ registered for our 7th Structural Variants, Graph genomes #bioinformatics #hackathon: https://t.co/QDdqGvHRYY… Registration closes 10th of Aug! Groups will work on interesting topics that will be published in F1000. @BCM_HGSC @BCMFromtheLabs @RiceCompSci
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Genetics Society of America Early Career Medal recipient Dr. Shinya Yamamoto shares how his veterinary training helped shape his approach to model organism research. https://t.co/iQAju0Z6tr
#BCMFaculty
genestogenomes.org
Genetics Society of America Early Career Medal recipient Shinya Yamamoto credits his broad veterinary training with shaping his open-minded approach to model organisms, collaborative research, and...
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Our paper that started commercial wearables for health monitoring and disease detection just hit 500 citations:
journals.plos.org
Author Summary A new wave of wearable sensors allows frequent and continuous measurements of body functions (physiology), including heart rate, skin temperature, blood oxygen levels, and physical...
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We've designed an RNA-targeted small molecule that reduces toxic 4R tau protein linked to FTDP-17. This orally bioavailable and brain-penetrant compound shows promise in mitigating cellular pathologies and behavioral phenotypes in mouse models. Link here https://t.co/wpDqFLyNiI
biorxiv.org
Frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) is caused by the aberrant alternative pre-mRNA splicing of microtubule-associated protein tau ( MAPT ) exon 10, the...
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Noah built a platform to discover covalent small molecules that react with RNA. Many protein-reactive warheads also react with RNA. We then Converted a DNA binder into a rna covalent compound. Preprint: https://t.co/JguMSDjKgk
#RNA #CovalentDrugs #ChemicalBiology #DrugDiscovery
biorxiv.org
RNA is a key drug target that can be modulated by small molecules, however covalent binders of RNA remain largely unexplored. Using a high-throughput mass spectrometry screen of 2,000 electrophilic...
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