So proud of this paper! It has been a privilege to develop this project with my first PhD student Neha Cheemalavagu, together with @DoctorF

I hate downloading new apps, but this was a good call. I hope you post your science, good news, and memes on Bluesky soon. Byeeeeee.

Vote before you go to lab

How good is our understanding of signaling pathways? In this study together w/ @savitski_lab @EMBL, we combine multiple state-of-the-art resources to evaluate signaling pathway inference using phosphoproteomics and kinase-substrate networks https://t.co/T2iIKGYuiZ

What a week with two publications from our lab! Spatial microniches of IL-2 drive lung migratory Th2 cells to allergens in NI & a review on Systems Immunology Approaches to studying T cells in npj Systems Biology.

While the Fth1-mScarlet will not enable quantification of macrophage inflammatory program as intended, this is a great tool if you are interested in monocyte activation and differentiation into macrophages. Also really nicely marks several tissue macrophage populations.

Check out our new paper and let me know if you are interested in using the Fth1-mScarlet mice. https://t.co/Ys1izp5aTx

Double champion! Congratulations Sonia. So proud!

In 2014 I joined the fledgling Tumor Microenvironment Center @UPMCHillmanCC w @RobertFerrisMD and @VignaliLab, taking a holistic view of cancer by unifying faculty interested in a ‘piece’ of its environment (now 7 investigators!). Today, I announce that we are GROWING! 1/

Check all the reviews in the special Innate Immunity issue, led by @jkagan1

Linking signal input, cell state, and spatial context to inflammatory responses. This was fun to write!

Hello folks! With exciting new grants and new projects in our lab, ✨we are hiring!✨ Please share with prospective Ph.D. students and/or postdocs interested in evolution, genetics, and microbes!

Excited to share our study of T cell signaling, where we directed high-content, single-cell genetic screening to uncover how a single adapter protein orchestrates a complex cellular process essential for health. (1/14) https://t.co/MmGF01YVLn

A new publication from our lab: How aberrant mitochondrial DNA synthesis in macrophages affects inflammation and atherosclerosis. https://t.co/JgMV4ifojR by @Niranjana89 Jonathan Florentin, and many collaborators- @jishnu1729 @SrutiShiva @KrithikaSRao Yingze Zhang, Sina Tavakoli

Excited to share our paper out today in @CellCellPress with @BcellBruno @Vignali_Lab! Part of a trio of papers, we show in #Melanoma, anti-PD1+anti-LAG3 therapy modifies CD8 differentiation to promote enhanced effector function

Please retweet and share with Pittsburgh undergraduates interested in immunology and microbiology!

Check out the N&V in @NatImmunol by Inaki Sanz about @elsner_rebecca @ShlomchikLab's recent paper on how B cell intrinsic IL-12 promotes EF and suppresses GC responses via an autocrine positive feedback loop with IFNg.

THANK YOU!!!! to the AMAZING cell signaling community for a fantastic inaugural Dynamics and Encoding in Cell Signaling FASEB meeting. We look forward to getting together in 2026!

Why are there so few drugs that target innate immune signaling pathways? Maybe bc we know so little about the natural protein interactions (and dynamics) that mediate innate immunity. A bottleneck for drug discovery may be understanding endogenous innate immune cell biology.

Our paper on plasma membrane abundance and phagocytosis is out in Science Immunology! Congratulations to ace myeloid mechanobiologist Ben Winer (@BenjaminYWiner) and also to our collaborators Orion Weiner (@OWeinerLab) and Jason Cyster. https://t.co/LbeQRTkXi7

A whole lot is going on in the nucleus of TLR4 stimulated macrophages. Distinct chromatin remodeling factors act at distinct loci to mediate inflammation. Kudos to Hargreaves and colleagues on this important study. @HargreavesLab @salkinstitute https://t.co/T34Svz60nl