Ph.Gabriel Steg
@gabrielsteg
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Abelacimab appears to be safe in AF patients receiving oral antiplatelet therapy, particularly in those with high bleeding risk. However, efficacy and dosing need to be determined in future trials of factor XI antagonists. @gabrielsteg
ahajournals.org
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After ACS on high-intensity statins, LDL-C, hs-CRP & Lp(a) independently predict future CV events. For Lp(a) & hs-CRP, risk starts at low levels. @VeraBittner2 @DLBhattMD @W66588221White @HeartBobH @gabrielsteg
https://t.co/lshJwXcD4u
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#ODYSSEY: LDL-C, Lp(a), and hs-CRP provide prediction of MACE risk after ACS. For hs-CRP and lipoprotein(a), risk starts at low levels. LDL-C and hs-CRP are predictors of death, Lp(a) not. @gabrielsteg @SABOURETCardio @DLBHATTMD @cpgale3 @mmamas1973 @pash22 @CircAHA #CardioX
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Therapeutic anticoagulation prevents and treats thromboembolism but increases the risk of bleeding. Factor XI, crucial for thrombus expansion but less so for haemostasis, is a promising target. Our Review discusses the rationale, pharmacology, evidence and future directions of
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What is the interaction of red blood cell transfusion and revascularization in acute MI? Analysis of the MINT Trial. Presented at @ACCinTouch #ACC25 and published simultaneously #cardiotwitter #AHAJournals @gabrielsteg @brianjpotter11 @herbaronowMD
https://t.co/tvsySOSDsy
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Thanks so much @JACCJournals for showcasing our study led by 🌟@SinaRsh w support from🗺️experts: OAC monotherapy is✅for most pts w AF + stable CAD. Awaiting data from #AQUATIC. Do the results apply to other indications such as mechanical valves or VTE + stable ASCVD?🤔
In patients with #AFib and stable #cvCAD, OAC monotherapy, compared with OAC plus SAPT, was not associated with a statistically significant increased risk of ischemic events but resulted in a significantly reduced risk of bleeding. https://t.co/vOen1sLSZX
#JACC #cvCoag @bbikdeli
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Credibility assessment of a mechanistic model of atherosclerosis to predict cardiovascular outcomes under lipid-low…
pubmed.ncbi.nlm.nih.gov
Demonstrating cardiovascular (CV) benefits with lipid-lowering therapy (LLT) requires long-term randomized clinical trials (RCTs) with thousands of patients. Innovative approaches such as in silico...
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Anticoagulation and Antiplatelet Therapy for Atrial Fibrillation and Stable Coronary Disease: Meta-Analysis of Rand…
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What is the evidence behind new categories of elevated blood pressure in the ESC Hypertension Guidelines? @EmmaVP5 @gabrielsteg @hopitalbichat
https://t.co/23d66zCGdA
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86% of subjects are not abnormal ! New Definition of Elevated Blood Pressure in the 2024 ESC Guidelines: Increased Prevalence, Uncertain Evidence our piece published today in Circulation https://t.co/yIrFhwXjwu
#hypertension #prevention @EmmaVP5
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Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low‐Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE‐IT Randomized Trial | Journal of the American Heart Association https://t.co/rNfPKMVhw2
@DLBHATTMD #EPA #prevention
ahajournals.org
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AMI-Sleep: protocol for a prospective study of sleep-disordered breathing/sleep apnoea syndrome and incident cardio…
pubmed.ncbi.nlm.nih.gov
ClinicalTrials.gov, NCT04064593.
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Carson et al. report results of an individual patient data meta-analysis of 4 RCTs that tackle this question. 🩸💓 Read the full results: https://t.co/4CaC577hB6
@SVRaoMD @gabrielsteg @JDawnAbbott1
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Patient-level meta-analysis of RBC transfusion trials in MI and anemia by Jeff Carson @gabrielsteg and colleagues. @AGoldsweig's poll indicated most would maintain Hgb 8 g/dl in this situation, but 10 g/dl might be better for long-term survival.
Carson et al. report results of an individual patient data meta-analysis of 4 RCTs that tackle this question. 🩸💓 Read the full results: https://t.co/4CaC577hB6
@SVRaoMD @gabrielsteg @JDawnAbbott1
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Interesting poll. We have evidence now but it's not so straightforward. Some newer data from the @nih_nhlbi funded MINT trial forthcoming. @gabrielsteg @CMichaelGibson @SripalBangalore @mmamas1973
A 75yo woman with CKD is admitted w/ type I NSTEMI. Hgb is 7.7 g/dL. Should you TRANSFUSE? To what target??? Look for new data from the MINT trial next week! @SVRaoMD @gabrielsteg @ShaunGoodman @SimonTabassome @brianpotter11 @JDawnAbbott1 @ACCinTouch @SCAI @American_Heart
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A 75yo woman with CKD is admitted w/ type I NSTEMI. Hgb is 7.7 g/dL. Should you TRANSFUSE? To what target??? Look for new data from the MINT trial next week! @SVRaoMD @gabrielsteg @ShaunGoodman @SimonTabassome @brianpotter11 @JDawnAbbott1 @ACCinTouch @SCAI @American_Heart
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Important evidence coming out next monday regarding transfusion strategies in MI... Stay tuned ! @SVRaoMD @SimonTabassome @andrewgoldsweig @jeffCarson @ShaunGoodman @deanfergusson @marniebertolet @mariabrooks #Transfusion
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