
Fred Howard
@fredhow
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Breast Medical Oncologist @UCCancerCenter | Former chief resident @YaleIMed | Using big data and AI to answer clinical questions in breast cancer care
Chicago, IL
Joined March 2009
🚨 New article alert!! 🚨 A great new piece in @Annals_Oncology about the benefits of anthracyclines in certain types of #BreastCancer: https://t.co/WoRTiXXEW1 from Drs. @fredhow, @MsNanchen, & others! @UCCancerCenter // @UChicagoMed
annalsofoncology.org
The benefit of anthracyclines for patients with high 21-gene recurrence score (RS) is unclear, despite the widespread use of RS to guide adjuvant chemotherapy treatment for hormone receptor (HR)-po...
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In a new commentary Freeman et al. points out that patients with ER-low tumors may not benefit from estrogen therapy in adjuvant setting, suggesting re-evaluation of systemic treatment strategies. @UChicagoHemOnc @RitaNandaMD @fredhow @uchicago_obgyn
https://t.co/jfuTlNWnhn
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🔥Hot off the press: In a new study, @UChicagoMed’s researchers found that triple-negative breast cancer patients with lower socioeconomic status have less access to life-saving treatments. @JAMANetworkOpen @fredhow @spshubeck @UChicagoHemOnc @UChicagoPHS
https://t.co/ouRhacK4CL
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2 important articles in the @JCO_ASCO Top Articles of 2024: https://t.co/fSyqJr5LKI in @JCOCCI_ASCO by Dr. @fredhow, Dr. Pearson, Anran Li, & colleagues and https://t.co/xphpHSwuDQ in JCO Oncology Advances by Drs. Huo, @RitaNandaMD, @MsNanchen, @fredhow from Hem/Onc & colleagues!
ascopubs.org
PURPOSEHuman epidermal growth factor receptor 2 (HER2)–targeted therapy improves outcomes in HER2+ breast cancer, but efficacy in cases with discordant immunohistochemistry (IHC) and in situ hybrid...
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Jazzed to see our work describing *potential LLM use trends in @ASCO abstracts* as one of the @JCO_ASCO family top articles of 2024. Check out all the top articles here: https://t.co/ug48QHEHte.
@fredhow @LGM_Biostats @JCOCCI_ASCO @UCCancerCenter @UChicagoBSD
ascopubs.org
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Congratulations to @NUCATSInstitute member @CatGaoHow, who has been named Associate Director of @IAIM_NU 's Center for Collaborative AI in Healthcare. A physician-scientist, Gao’s research focuses on leveraging machine learning to enhance ICU patient care https://t.co/WStoB4jobA
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So honored and grateful for this! Thanks to all the mentors and team members who have supported me. 💖 Looking forward to exciting new work together with @IAIM_NU @IPHAM_CHIP @NM_Lung @NUFeinbergMed and many others!
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Exciting work in @Nature_NPJ from @UChiPritzker's Asim Dhungana - predicting recurrence from quantitative IHC using #machinelearning, prognostic in Oncotype high/low risk cases, calculator at https://t.co/NjrzUCM7e7
@UCCancerCenter @UChicagoBreast #bcsm
nature.com
npj Breast Cancer - Development and validation of a clinical breast cancer tool for accurate prediction of recurrence
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‼️ #ASCO24 simultaneous publication by @lab_pearson et al: Characterizing the Increase in Artificial Intelligence Content Detection in Oncology Scientific Abstracts from 2021 to 2023: ➡️ https://t.co/xSOZoZ0Sup
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@fredhow presents an excellent poster at #ASCO24 showing increased use of ChatGPT in generating scientific abstracts directed towards need to bring new policies. @Lab_Pearson @UCCancerCenter @UChicagoHemOnc
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@UChiPritzker @fredhow @ASCO @LGM_Biostats @OpenAI @jcocci_asco will publish @fredhow @LGM_Biostats work "Characterizing the Increase in Artificial Intelligence Content Detection in Oncology Scientific Abstracts from 2021 to 2023" and #JCOCCI EIC Dr. Jeremy Warner to discuss live. 📍June 2, 10:00AM S403B. (Journals Lounge) (4/n)
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Excited to share our study of RSClin in 280k pts https://t.co/BnLgQDafkK In the lowest risk pts per RSClin-no chemo benefit even if Oncotype high. For high risk-question of OFS vs chemo remains (I vote OFS) Congrats Augustin! @GenomicHealth @folopade @RitaNandaMD @UChicagoBreast
acsjournals.onlinelibrary.wiley.com
Although developed to predict distant recurrence rates, RSClin predictions correlate well with overall survival for patients receiving endocrine therapy with or without chemotherapy. RSClin may...
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Absolutely outstanding discussion of AI based predictors specifically around lobular breast cancer by @fredhow @UChicagoMed following amazing work by @FresiaPareja in the Reis Filho lab
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Augustin Vannier discusses the data in today’s poster session at #ASCO23. He explains the utilization of genomic data to identify the patients that benefit from chemotherapy treatment. @fredhow @UCCancerCenter @UChicagoMed @UChicagoHemOnc
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Our latest paper, "Deep learning generates synthetic cancer histology for explainability and education", is out! https://t.co/MYM446Ml4Z. We use #digitalpathology AI for 🧪 scientific discovery & 🏫 education by enabling deep neural networks to "teach back" what they learn. (1/5)
nature.com
npj Precision Oncology - Deep learning generates synthetic cancer histology for explainability and education
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Overjoyed to see CarpeDiem out in @jclinicalinvest! We used #machinelearning to examine unresolving pneumonia here: https://t.co/TVuMBxd0VM
@NM_Lung @NUFeinbergMed @NIAIDNews @nsmarkov @macwalterMD @RoganAGrant @lrasmus
@yuanhypnosluo @ScottBudinger @Misharin_lab @bsinger007
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Validating a low-cost, open-source, locally manufactured workstation and computational pipeline for automated histopathology evaluation using deep learning https://t.co/T1Av5OJdaI
#bioRxiv
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Topical content... Blinded human reviewers only detected 68% of #ChatGPT generated scientific abstracts, despite incorrectly identifying 14% of real abstracts as being generated. https://t.co/mKWr977aeT
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In an analysis of over one million pts with #breastcancer, HER2-low status had minimal impact on breast cancer survival & chemotherapy response when compared to HER2-0 disease in an analysis prior to introduction of potent antibody-drug conjugates. https://t.co/Z4T9r6MzBU
#BCSM
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Now out in @npjDigitalMed! We found that #ChatGPT could generate scientific abstracts that were often difficult to distinguish from real abstracts. Hallucinates though, so needs careful review! Cheers & thanks: @fredhow @nsmarkov @EmmaChancellor Sid @yuanhypnosluo @lab_pearson
New article! Read Comparing scientific abstracts generated by ChatGPT to real abstracts with detectors and blinded human reviewers https://t.co/X5DiiuODE3 in npj Digital Med
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