Ferran Nadal-Bufi
@fnadalbufi
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Postdoctoral Research Fellow at @Dynafluors @EdinburghUni. PhD at @STHenriquesLab & @theCraikGroup. Dad.
Edinburgh, Scotland, UK
Joined March 2018
🚨Exciting news!🚨 Our latest work is out in @J_A_C_S! A Fluorogenic Platform for Real-Time Imaging of Subcellular Payload Release in Antibody-Drug Conjugates @dynafluors @EdinUni_IRR @abbvie 🧵👇.
pubs.acs.org
Antibody–drug conjugates (ADCs) represent promising therapeutic constructs to enhance the selective delivery of drugs to target cells; however, attaining precise control over the timing and location...
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RT @ACBCOM: ✍️ Jesús Ramírez, nuevo entrenador de @casademontBZ . El técnico firma para las próximas cuatro temporadas (dos temporadas ampl….
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RT @MathewHHorrocks: Check out our new single-molecule liposome assay for studying membrane disruption! Well done to all involved. @Edinbur….
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Grateful to be part of this amazing work! Big thanks to Omer and Muhammad for bringing me in on this cool project in protein design and total synthesis.
Thrilled to share our latest work: Abiotic Transcription Factors by Strategic Insertion of Non-Proteinogenic Amino Acids. Appeared today on @ChemRxiv.Exciting collaboration with @dynafluors & @Afek7Afek.Congrats to Omer, Ferran, and the rest of the team!
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RT @J_A_C_S: Fluorogenic Platform for Real-Time Imaging of Subcellular Payload Release in Antibody–Drug Conjugates | Journal of the America….
pubs.acs.org
Antibody–drug conjugates (ADCs) represent promising therapeutic constructs to enhance the selective delivery of drugs to target cells; however, attaining precise control over the timing and location...
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Finally, a huge thanks to our collaborators at @abbvie for sharing their invaluable expertise and vision in the field of ADCs and for making this research possible through this successful academic-industry partnership.
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This modular technology offers unprecedented insights into the mechanism of action of ADCs, and it has the potential to transform ADC design into a more rational strategy, paving the way for next-generation ADCs with improved efficacy and fewer side effects. 👇.
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1) Subcellular location: Detecting ADCs in acidic compartments of the endolysosomal pathway by sensing pH changes. 2) Linker cleavage: Signalling ADC payload release upon enzymatic cleavage by proteases (e.g., cathepsin B). 👇.
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We developed an imaging platform that provides real-time insights into how ADCs behave at the cellular level. To achieve this, we designed dual-activatable fluorophores that act as molecular sensors, switching fluorescence OFF to ON in response to two key events: 👇.
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ADCs are a transformative class of advanced therapies. By chemically linking drugs to antibodies, ADCs can selectively deliver treatment to target cells, but where and when ADCs release their drug payloads? 👇.
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RT @duemed: Great session on ADCs (anti-drug conjugates) for advanced/metastatic bladder cancer at #GU25 . Great panel with @DiMariaJiang (….
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Our paper highlighted in a First Reactions article: Wash-free Imaging in Live Cells | ACS Central Science
pubs.acs.org
Palladium-mediated arylation enables minimal labeling of peptides and proteins with small fluorogenic amino acids for wash-free imaging.
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RT @ACSCentSci: Late-stage labeling to prepare unprotected fluorogenic peptides/proteins via Cys arylation with minimal bioactivity perturb….
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RT @JbaraM90: Late-Stage Minimal Labeling of Peptides and Proteins for Real-Time Imaging of Cellular Trafficking | Published today in @ACSC….
pubs.acs.org
The cellular uptake routes of peptides and proteins are complex and diverse, often handicapping therapeutic success. Understanding their mechanisms of internalization requires chemical derivatization...
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Proud to share our new work in @ACSCentSci 🚨 @dynafluors we've developed a minimal-labeling strategy for imaging peptides & proteins in live cells, and study cellular uptake and trafficking. Big thanks to @v_nithun @JbaraM90 for a fantastic collaboration!
pubs.acs.org
The cellular uptake routes of peptides and proteins are complex and diverse, often handicapping therapeutic success. Understanding their mechanisms of internalization requires chemical derivatization...
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RT @dynafluors: 💥 PhD Opportunities 💥.👩🔬 Are you interested in….Synthesis of organic fluorophores.Peptide/protein chemistry.Computational….
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RT @dynafluors: Our latest review on smart #photosensitizers for PDT in @NatRevChem. Good account on chemical strategies, targets and trans….
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RT @dynafluors: Chemo-click: our latest strategy to image subsets of cells. Rapid and modular approach, in principle suitable for many #che….
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RT @Stanford_ChEMH: Final session on ‘Intracellular chemical biology’ presenting research from Michael Rape @RapeLab, Laura Dassama @lmkdas….
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