Excited to see the MEGA gut paper, which I had the privilege to contribute to, now published in Nature! Congrats to the entire team on this amazing work! 🎉👏 Check out the quoted thread for our key findings. In this thread, I’ll highlight scAutoQC developed by Ni Huang. 🧵

🔗 Data to explore: [ https://t.co/sjYHGKevU6](https://t.co/sjYHGKevU6) 📖 Full article: [10.1038/s41586-024-07571-1]( https://t.co/wNgrOSoGhZ)

This was a fantastic collaboration! Huge thanks to @AmandaOPhD & @Teichlab for co-leading this work, & stellar collaborators @saezlab, @Muzz_Haniffa, @PKlenermanLab, @Zilbauer_M, @KSaebParsy, @frode_jahnsen, Salas lab, K.R. James, M. Høivik, C. Stewart, J. Berrington & all!

Gastric metaplasia isn’t just about healing! INFLAREs recruit immune cells (e.g., T cells, neutrophils) via chemokines like CXCL2 & CXCL5, and may interact with CD4+ T cells via MHC class II. They may amplify disease through these functions.

Where do INFLAREs come from? Trajectory analysis by Dinithi Sumanaweera, Lisa Marie Milchsack & team showed that INFLAREs originate from LGR5+ stem cells. Inflammation redirects stem cells toward this metaplastic lineage while preserving their stem-like properties.

What is metaplasia? It’s when one type of mature cell is replaced by another not typical for that tissue—often a response to chronic injury or inflammation. Protective at first, it can fuel disease by driving inflammation or cancer.

Mapping disease onto our healthy reference revealed gastric epithelial cells in the intestines of IBD patients—a rare process known as metaplasia. We call these cells inflammatory epithelial cells or INFLAREs 🔥.

To achieve fast, high-quality integration, we developed scAutoQC ( https://t.co/LfaBEk4fSr). Huge shoutout to Ni Huang, Krzysztof Polanski, Nick England, @slobentanzer and team for this brilliant tool! 🚀

I am beyond excited to see our MEGA gut paper published in @Nature! 🌟 Over 5 years, 20+ datasets profiled cells of the human gut. We created a mega dataset spanning health & disease (~1.6M cells) as a reference to study inflammation. 🧵Follow along for your daily gut wisdom.

Rasa Elmentaite from Teichmann lab at introduces the Human Cell Atlas @humancellatlas at the https://t.co/RzOnETukl8 meeting.

🎉Congratulations to the @_BSDB_ Beddington Medal winner Rasa Elmentaite @elmentaite!! #EDBC2023 We caught up with Rasa earlier to learn more about about her background, her PhD work on the Gut Cell Atlas @sangerinstitute, and her future plans: https://t.co/xUnnoBfL6U

I am thrilled to be awarded the BSDB Beddington medal for my PhD work on mapping the cells of the human gut. What a privilege!🏅 Special thank you to BSDB committee & my supervisor Sarah and @teichlab for your support throughout my PhD and beyond. ♥️

We're thrilled to announce that Rasa Elmentaite @elmentaite, a former TeichLab PhD student, phenomenal young scientist, has been awarded the prestigious Beddington Medal by @TheBSDB for her groundbreaking work in human gut development. 🧬🏅 Read more:

Together with my colleagues Commercial Attache & Economic Advisor spent a day at the Cambridge Genome Campus to learn about The Sanger Institute, The European Molecular Biology Laboratory & ELIXIR. Also presented an event "Life Science Baltic" event held in Vilnius in autumn.

Join us for #EISingleCell23 in May where we'll hear from @SueRhee2, @wormduty, @yang__wang, Charles ffrench-Constant (@UeaMed) and @elmentaite. 📍 Earlham Institute, Norwich, UK 🗓️ Register by 16 April 2023 ➡ https://t.co/4BUk7hsYir @biouea @Co_Biologists @NorwichResearch

Want to achieve real #equality? We need to start with this. Inspiration, motivation and goodwill won't get us far - we need robust childcare legislation #InternationalWomensDay https://t.co/mLkJQikWrX

Wonderful to see this Perspectives article in @NatureMedicine, showing the impact the HCA is already having on medicine. https://t.co/466RgtVeYH

We’ve had 2️⃣ very engaging sessions on our #EngineeringBiology track! ‘Predictive models to enable engineering biology’ and ‘Scaling engineering biology through industry 4.0’ #TechBioUK

Excited about the spatial transcriptomics session at the UK Conference of Bioinformatics and Computational Biology on 29 Sep. Sarah will chair the session and @CataVallejosM @Mohlotf @emmamarydann will present their recent awesome work on new methods for biological data analysis.