Daniel Starczynowski
@dstarczynowski
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Professor at Cincinnati Children’s Hospital. Cancer biologist focused on hematologic malignancies ( #MDS and #AML ). Views my own.
Joined December 2012
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![Guillaume [Asenka] Dorison](https://pbs.twimg.com/profile_images/1588604744964128769/qz6AaT-z.jpg)
We are excited to share our new paper in
@ScienceTM
describing UBE2N as a novel therapeutic target in
#AML
.
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Thrilled to share our new story in
@CellStemCell
- a tour de force team effort spearheaded by
@tchlon
. He identified that DDX41 mutations contribute to MDS through discrete mechanisms in monoallelic and biallelic mutant clones.
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We are excited to share our new paper in
@haematologica
describing the complex relationship between
#inflammation
,
#p53
, and
#MDS
. Congrats to lead author Tomoya Muto for spearheading the project.
8
25
144
We are excited to share our new story
@NatImmunol
on how an adaptation of MDS HSPCs to inflammation contributes to a competitive advantage. Congrats to Tomoya Muto and the awesome team
@garciamanero
@MDAndersonNews
@UCSF
@CincyChildrens
@LLSResearch
.
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Very proud that our lab was awarded the highest level of certification by
@My_Green_Lab
- the 1st at
@CincyChildrens
and in
#Ohio
! The
#GreenLabCertification
is the gold standard in lab sustainability practices. Huge thanks to Lyndsey Bolanos and our “sustainability champions”!
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We are excited to share our latest paper in
@BloodJournal
describing new functions of the IRAK1 & IRAK4 complex in MDS/AML, which has broad therapeutic implications.
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Congrats to Tomoya and Maria (
@Maguillamot
) on their new story in
@CellStemCell
- a tour de force team effort between the Starczynowski and
@iannisaifantis1
labs on a new tumor suppressor role of TRAF6 in
#AML
by targeting MYC activity:
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Excited to share our
@JExpMed
perspective on the emerging role of innate immune signaling dysregulation in hematopoietic aging, clonal hematopoiesis, and MDS. Huge thanks to the
@TrowbridgeLab
and
@dstarczynowski
lab members!
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Join us for the rescheduled but equally exciting Virtual Keystone Symposia April 21-23 2021 on the latest research in normal and malignant hematopoiesis.
#VKSHemato21
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Congrats
@Maddie_Science
! It is a bitter sweet day as it is her last day in the lab after a widely successful PhD. She is embarking on her postdoc with John Crispino
@StJudeResearch
. Maddie is a science rockstar and an awesome colleague! We will all miss her
@CincyChildrens
.
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If you are interested in how inflammation can impact
#MDS
, check out our new pre-print in
@biorxivpreprint
: Chronic inflammation suppresses del(5q)-like MDS HSCs via p53
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Happy to see the final version of our paper in the latest edition of
@BloodJournal
. In this paper, we describe new functions of the IRAK1 & IRAK4 complex in myeloid malignancies, shedding light on its therapeutic implications.
We are excited to share our latest paper in
@BloodJournal
describing new functions of the IRAK1 & IRAK4 complex in MDS/AML, which has broad therapeutic implications.
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Join us for the Keystone Hematopoiesis eSymposia April 21-23 2021. Deadline for short talks is March 10. Priority will be given to trainees and junior faculty. Email or DM if you have questions.
#VKSHemato21
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If you want to learn more about the emerging role of inflammation and cell-intrinsic dysregulation of innate immune pathways in
#myelodysplasia
, see the list of recent reviews. Tag me if there are any I've missed.
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Congratulations to
@Goodell_Lab
and
@Nina_CabezasW
! It is a tremendous honor to be recognized by
@ISEHSociety
. Thank you to everyone for all your support!!
Congratulations to our ISEH 2023 Society Scientific Award Winners! This week on
#SimplyBlood
we celebrate the achievements of this year's awardees:
@Goodell_Lab
,
@dstarczynowski
, and
@Nina_CabezasW
👉
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The Hematologic Malignancies Program
@CincyChildrens
is recruiting tenure-track faculty to pursue research on normal and malignant hematopoiesis. Retweet and share with your colleagues.
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Happy to see the final version of our paper in the latest edition of
@Haematologica
. We show that innate immune pathways contribute to MDS and that chronic inflammation may create a selective pressure for expansion of p53 mutant clones in del(5q) MDS.
We are excited to share our new paper in
@haematologica
describing the complex relationship between
#inflammation
,
#p53
, and
#MDS
. Congrats to lead author Tomoya Muto for spearheading the project.
8
25
144
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Excited to share our new story in
@CellReports
- a tour de force by
@Maddie_Science
. She identified TIFAB as a critical node in hematopoietic cells under stressed and oncogenic cell states.
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If you are interested in learning about the role of IRAK1 and IRAK4 in hematologic malignancies and recent therapeutic advances in the dawning era of IRAK-targeted therapy, check out Josh Bennett's new review in Current Opinion in Hematology:
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Congrats to
@Maddie_Science
on her new pub in
@LeukemiaJnl
on how USP15 modulates cellular redox and is a therapeutic target in
#AML
. Thanks to the team from
@CincyChildrens
and
@FORMAInc
for all their help!
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Thank you
@LLSResearch
@TheMarkFdn
@AllenInstitute
! I’m very grateful and honored to be among the recipients of the inaugural Blood Cancer Discoveries Grant. Congrats to the other recipients!
Read more about our amazing
#LLSDiscovery
scientists:
@bradleybio
@fredhutch
, Dr. Levy,
@majetilab
@StanfordMed
, Dr. Muschen
@cityofhope
, Dr. Schwab
@nyulangone
, Dr. Shipp
@DanaFarber
,
@SignerLab
, Dr. Jamieson
@UCSanDiego
,
@dstarczynowski
@CincyChildrens
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In a team effort with Thomas’ lab
@ncats_nih_gov
, we find that IRAK1/4 contributes to adaptive resistance to FLT3 inhibitors in FLT3+AML. Thanks to
@rosslevinemd
@JPCincyOnc
@LLSResearch
among many collaborators at
@CincyChildrens
@CHM_MSKCC
@uofcincy
:
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In a team effort with Verma & Boultwood labs, we show U2AF1 mutations induce oncogenic IRAK4 isoforms in MDS/AML
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Congratulations to Maddie for successfully defending her PhD thesis! She totally knocked it out of the park. This is no surprise as she is a science rock star!
@uc_ccb
@CincyChildrens
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Tomorrow is the official kickoff to the
#Keystone
#eSymposia
on Hematopoiesis! Looking forward to amazing science and connecting with colleagues. See you all soon!
Join us in next week for the
@KeystoneSymp
virtual
#eSymposia
,
#Hematopoiesis
, to explore emerging
#hematology
research and technology, with interactive discussions and networking opportunities! Register today at
#VKSHemato21
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Welcome all out of town guests to Cincy for
#MyeloidMeeting22
! Looking forward to seeing everyone and the science! If you arrived early, check out entertainment/dining options at The Banks (riverfront), OTR, and Central Business District. LMK if you want recommendations.
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Thanks
@AbdelWahablab
and Tanya for an amazing
#FASEBHM2019
. Outstanding science, great colleagues, and lots of tennis with
@rosslevinemd
@TheDoctorIsVin
@MNiederkornUC
@shengfcai
@tchlon
made for a memorable week
#Snowmass
#networking
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Yesterday was our annual UC Cancer Center Retreat - an exciting day of cancer research talks, vibrant discussions, and new collaborations! Lot’s of energy and amazing cancer research happening at
@UCincyMedicine
and
@CincyChildrens
!
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Congrats to
@Amitvermamds
, Jackie Boultwood, and the entire team! Excited to be part of this study on the role of
#IRAK4
in
#MDS
with SF3B1 mutations.
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Join us in next week for the
@KeystoneSymp
virtual
#eSymposia
,
#Hematopoiesis
, to explore emerging
#hematology
research and technology, with interactive discussions and networking opportunities! Register today at
#VKSHemato21
0
9
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Yesterday was our inaugural UC Cancer Center Retreat - an exciting day of research talks, vibrant discussions, and new collaborations!
@UCincyMedicine
@uc_health
@CincyChildrens
@SyedAAhmad5
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Huge congrats to
@CincyChildrens
for achieving
#1
US News ranking! Immense gratitude to our exceptional teams, whose unwavering dedication, innovation, and compassion deliver world-class care and impact. I’m proud to be part of this amazing team!
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Excited to share our new study in
@ScienceTM
by
@Kate_Mel_
on a novel therapeutic strategy for overcoming adaptive resistance to therapy in AML by targeting immune response pathways. Check out the link
@AAAS
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Exciting paper in
@CD_AACR
from Yoshihiro Hayashi and team at Tokyo University (
@toyaku_univ_pr
). They show mitochondrial fragmentation triggers ineffective hematopoiesis in
#MDS
in part via ROS production and inflammatory signaling. Congrats to the team!
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Mark your calendars for this amazing meeting!
Save the Date!
#ISEH2024
🎡 will be hosted in Chicago, USA from 29 August - 01 September 2024. Details on the scientific program, networking opportunities, and registration to come in early 2024 - but add us to your calendars now!
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Join us for an exciting
@KeystoneSymp
April 3-7 2020 on the latest research in normal and malignant hematopoiesis. Check out the speaker lineup, meeting info, and presentation opportunities.
#KShemato
.
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Join me for Day 2 of the
@KeystoneSymp
virtual eSymposia on Hematopoiesis! Another day of exciting talks!
#VKSHemato21
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One of my favorite events…our annual
@ChildrensCBDI
research retreat bringing together our oncologists, hematologists, scientists, and trainees. Awesome presentations and spirited discussions!
@CincyChildrens
#1
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Check out the new
#ASH23
scientific workshop on THERAPY RESISTANCE MECHANISMS IN BLOOD MALIGNANCIES
It covers epigenetic (
@MAF_Dawson
,
@jdlicht
,
@ManelEsteller
), posttranscriptional (
@ewang2323
,
@TzelepisLab
,
@coraline_mly
, Jason Cheng) posttranslational (
@dstarczynowski
,
@PapapetrouMDPhD
, Li Du) and metabolic (
@glytsou
,
@majetilab
, Courtney Jones) aspects of therapy resistance
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New study from the team at
@MoffittNews
implicating immune signaling in
#MDS
: Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS-STING-NLRP3 axis in
#MDS
@JCI_insight
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Today is the last day of the
@KeystoneSymp
eSymposia
#Hematopoiesis
! See you all soon for one more day of awesome science talks.
#VKSHemato21
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Congrats to the 2021 ASH Scholar Award recipients!
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Congrats to LaQuita Jones for her paper
@jclinicalinvest
on targeting AML-associated FLT3 mutations. With Craig Thomas’ team
@ncats_nih_gov
, we describe a novel IRAK1/4-FLT3 inhibitor that targets clinically-relevant FLT3 mutations:
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New Leader for Immunobiology!
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Exciting news!
@FortuneMagazine
has once again recognized
@CincyChildrens
as the nation's most innovative children's hospital! Huge shoutout to the incredible faculty and staff pushing the boundaries of child healthcare innovation.
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Kurome Therapeutics Announces FDA Clearance of Investigational New Drug (IND) Application for KME-0584 for the Treatment of Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndromes (MDS)
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There is only 1 week left to submit an abstract for the
@KeystoneSymp
April 3-7 2020 on the latest research in normal and malignant hematopoiesis. Check out the updated meeting info ().
#KShemato
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If you want to learn more about the role of FHA-domain proteins in inflammation, hematopoiesis, and disease see our recent review
@ISEHSociety
. Kudos to
@Maddie_Science
and
@Puneet1080
for an awesome job!
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One of my favorite events…our annual
@ChildrensCBDI
research retreat bringing together our oncologists, hematologists, scientists, and trainees. Awesome presentations and spirited discussions!
@CincyChildrens
#1
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CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia
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@CincyChildrens
Ranked Best Children's Hospital in the Nation by US News! Also,
#1
in Cancer, Neonatology, Urology, and Endocrinology!
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Postdocs under pressure: ‘Can I even do this any more?’
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Thanks
@garciamanero
and for everyone in
@LeukemiaMDA
for tuning in! I appreciate the great feedback and incredibly helpful discussion.
Dr Starczynowski speaking at mdacc today.
@LeukemiaMDA
@dstarczynowski
Fantastic talk and topic from a leader in field of innate immune alterations in cancer.
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Important study from Dan Link’s team in
@BloodJournal
: Increased dendritic cell TLR1/2 signaling may contribute to altered HSPC function in
#MDS
by increasing local IL-1b expression.
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5
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New
@ASH_hematology
Scientific Workshop: Therapy resistance mechanisms in blood malignancies. See info 👇
Interested in mechanisms of therapy resistance in blood cancers? Attend the first ASH Workshop on this topic co-organized by Dan Starczynowski
@dstarczynowski
, Christina Glytsou
@glytsou
, and myself during
#ASH23
: 1/
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NCI is increasing the R01 payline to the 12th percentile in fiscal year 2023, up from the 11th percentile in FY22—bringing the institute’s payline to a level not seen since 2010.
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Congrats Tim! Way to go!
Congratulations to Tim Chlon, PhD (
@tchlon
), on being selected along with 32 other recipients for the 2023
@ASH_hematology
Scholar Award. Read the full announcement:
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Thank you for highlighting our review on the IRAK1 & IRAK4 kinase complex and its potential as a therapeutic target in inflammatory conditions and oncology!
🚨 Sharing our top read papers of 2023! 🚨
The review of therapeutic advances in the dawning era of IRAK-targeted therapy, from Joshua Bennett & Daniel Starczynowski
@dstarczynowski
from
@CincyChildrens
is our top read review of 2023!
🔗
Read more ⬇️
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Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated
#MDS
@ScienceTM
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Scholarship applications for free registration due TOMORROW for
#Hematopoiesis
#eSymposia
.
Scholarship apps. for free registration to LMIC & early career scientists due TOMORROW for
#Hematopoiesis
#eSymposia
. Organizers
@dstarczynowski
@rosslevinemd
@MikkolaLab
have assembled an amazing program covering
#HSCs
#LeukemiaResearch
#AML
& more.
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New MDS funding opportunity: The new Taub Foundation Pilot award will provide seed money for transformative ideas in MDS. The award supports proof-of-concept studies addressing critical roadblocks to understanding MDS and its treatment.
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There is only one week left to apply for
@KeystoneSymp
Hematopoiesis Meeting Scholarships (deadline Dec. 5): .
Not only are KS Scholarships prestigious, but they also provide invaluable networking and career-development opportunities.
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MDS Workshop starting today. Experts will discuss the critical steps & approaches required to advance the field of
#MDS
and its treatment paradigm. Virtual option available.
@Dr_AmerZeidan
@garciamanero
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Join us in April 2021 for the
@KeystoneSymp
virtual
#eSymposia
,
#Hematopoiesis
, to explore emerging
#hematology
research and technology, with interactive discussions and networking opportunities! Register today at
#VKSHemato21
1
5
19
The new University of Cincinnati Cancer Center (partnership between
@uc_health
and
@CincyChildrens
) named in National Top 60 Cancer Programs
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The German company BioNTech, founded by 2 scientists - husband/wife team - has teamed up with Pfizer on leading their RNA-based vaccine for Covid-19. Their inspirational story
@nytimes
.
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Yes, I’ve heard many mispronunciations of my name. Here is an easy way to pronounce it and only 4 syllables: “Star•chin•off•ski”
@tmprowell
I usually get "Steinman" or "Stensman". I've heard Raf Bejar introduced as "Bee-jar" like a Mason jar full of honeybees (he's Uruguayan descent, so the j is like an h), and some moderators don't even know where to start with Dan Starczynowski
@dstarczynowski
or Ari Giagounidis.
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The 2023 Dresner Foundation MDS Research Fund is open for applications! Deadline = March 17. Please share with your colleagues.
@aamdsif
@MDSFoundation
@MDSAlliance
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There is only a few days left to submit an abstract for the
@KeystoneSymp
April 3-7 2020 on the latest research in normal and malignant hematopoiesis! Abstract are due Jan 9th, 2020. Check out the latest meeting info ().
#KShemato
.
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ASH Myeloid Workshop is accepting abstract submissions - junior PIs only! Great opportunity to showcase your research. Spread the word!
@tchlon
@SignerLab
@MarieDo95228975
@BeaudinLab
@SaraMeyerLab
@KharasLab
ASH myeloid workshop: All talks from junior PIs only (<5 years since starting your independent lab) - an exciting, unprecedented opportunity to get yourself and your science out there! Spread the word!
@TheKingLab
@Goodell_Lab
@Doulatov_lab
@dstarczynowski
@bloodandtime1
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Devastating news and huge loss for
@CincyChildrens
. Hector was an amazing leader and colleague, and a world-class physician-scientist. He was instrumental to advancing our clinical, research and education missions. Our heartfelt condolences to his family. He will be deeply missed
It is with deep sadness that we mourn the loss of Hector Wong, MD, vice chair of the Department of Pediatrics at Cincinnati Children’s and a leader in critical care medicine research, who passed away unexpectedly over the weekend. He was 58.
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The Vera and Joseph Dresner Foundation’s is accepting Letters of Inquiry for its
#MDS
Research Fund. Early Career and Established Investigators are invited to apply. Deadline = March 15, 2024
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Congrats Daniel and the entire team! Another remarkable discovery!
I am really pleased to share our latest manuscript, just published
@Nature
! You can access the manuscript (open access) here:
Special thanks to Maria Carolina Florian for the great commentary:
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@CincyChildrens
named one of nation’s most innovative companies by
@FortuneMagazine
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Thanks
@theclotthickens
!
@tchlon
from my group will present his exciting findings on the inherited
#MDS
gene DDX41!
After
@anandi_krishnan
, be sure to stay signed in for THURSDAY TRAINEE HOUR 🥳from 2-3pm EDT. Today we will be treated to talks from
@LMHaynesPhD
,
@tchlon
, and Massiel Stolla.
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Congrats to Tomoya Muto for the Outstanding Abstract Achievement Award at
#ASH19
! He’ll be presenting Monday (Session 603 - abstract 727) on a novel mechanism of MYC activation in AML/MPN.
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One of my favorite events…our annual
@ChildrensCBDI
research retreat bringing together our oncologists, hematologists, scientists, and trainees. Awesome presentations and spirited discussions!
@CincyChildrens
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NIH advisory group recommends $14,000 boost in postdoc pay
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Ride Cincinnati Kickoff Event…raising money for cancer research in Cincinnati (UC+CCHMC)!
@CincyChildrens
@uofcincycancer
@ChildrensCBDI
@UCincyMedicine
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Congratulations to all of the recipients of this year’s ISEH awards!
ISEH is proud to announce the winners of our 2024 Society Awards!
Scientific Award Winners: Emmanuelle Passegué, Ravindra 'Ravi' Majeti and Robert Signer
Leadership Award Winners: Ross Levine and Katherine King
Read more about this year's winners here 👉
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Congratulations
@Maddie_Science
! Obviously you will be terribly missed by all of us in the lab, but I am very excited to see you continue on your amazing scientific journey with John Crispino
@StJudeResearch
!
You know that excitement of college signing day, when athletes put on the hat for their new team?
Ok so I’m definitely not a college athlete but I feel that sense of excitement to share that for my postdoc, I’ll be joining John Crispino’s lab
@StJudeResearch
in January. 😀🩸🔬
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Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells
@CellRepMed
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@LLSResearch
@majetilab
@Akihide_Yoshimi
@DrMattWit
Congratulations to
@majetilab
@Akihide_Yoshimi
@DrMattWit
for being selected for the
@LLSCDP
Achievement Award! I am honored and humbled to be among this amazing group of recipients! Grateful to my collaborators and lab members and for the support of
@LLSResearch
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Great thread on
#Cincinnati
! A hidden gem!
Wondering about
#Cincinnati
because...
@Bengals
?
Some things to know. 🧵
Cincinnati was a boomtown in the 1800s—one of the 10 largest cities in USA for most of the 19th century. So..
Our
#architecture
is a stunner—it looks like lower Manhattan b/c it was built at the same time.
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Congrats to the amazing team at
@Cancerfreekids
! Supporting transformative research ideas will accelerate the discovery of novel treatments for pediatric cancers!
@ChildrensCBDI
@nationwidekids
@CincyChildrens
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Welcoming news from FDU (my alma mater) for many still struggling financially during the pandemic. Hope other institutions follow and reduce tuition during these times so all students can continue their studies!
#myfdu
Fairleigh Dickinson University reduces undergraduate tuition for all new full-time students beginning in fall of 2021 via
@News12NJ
:
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@CincyKidsOAACD
@CincyChildrens
I’m very grateful for the unwavering support of
@CincyChildrens
. Thank you for the gracious recognition!
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Annual Scientific Conference — RUNX1 Research Program (
@RUNX1Research
). Exciting speaker line up…hot research topics!
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Looking forward to it!
Not one but TWO talks for me at
#ASH21
. I will present my lab’s most recent findings on DDX41 mutations in MDS at the Scientific Workshop on Bone Marrow Failure on Friday and on Saturday 12-1:30pm in session 636 MDS: Basic and Translational
@ASH_hematology
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