Daniel Starczynowski
@dstarczynowski
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Professor at Cincinnati Children’s Hospital. Cancer biologist focused on hematologic malignancies (#MDS and #AML). Views my own.
Joined December 2012
The NIH has additional opportunities available for exceptional senior-level candidates to lead Institutes and the Intramural Research Program within the NIH. These leadership roles provide overall executive direction and scientific leadership for the Institutes mission and
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Congratulations to Emma Uible (Vontz) (@emmavontz) on successfully defending her PhD thesis! Your dedication and perseverance have truly paid off — wishing you continued success and many exciting opportunities ahead!
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Predicting protein-protein interactions in the human proteome Predicting which human proteins shake hands—and how—is a longstanding bottleneck. Proteins rarely act alone; they assemble into complexes that drive immunity, metabolism, signaling, and disease. But testing hundreds
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Exciting new review from Eric Vick! Explore the emerging role of IRAK1/4 as therapeutic targets in cancer and recent advances shaping the next era of IRAK-directed therapies. @tandfonline @CincyChildren @ChildrensCBDI @UofCincyCancer
tandfonline.com
All human cells have the capacity to respond to damage or danger through conserved signaling pathways that converge on interleukin-1 receptor-associated kinases (IRAKs). IRAKs are a family of kinas...
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Congrats Ross!!
Dr. Ross Levine (@rosslevinemd), Senior Vice President of Translational Research at MSK, has been named MSK's new Chief Scientific Officer (CSO). Dr. Levine will be responsible for setting and leading strategy for basic and translational research, including programs, centers,
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What got us here isn’t a scorecard. It’s culture and how our team shows up. Expertise + heart at the bedside, relentless science & innovation, team-of-teams execution. Kinder cures and better lives for children & AYAs—here and everywhere we serve. #ChildhoodCancer #AYACancer
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The 1st Annual Cincinnati Leukemia Research Retreat is off to a great start! We just finished Session 1 on Genetics, Gene Expressions and Functional Genomics.
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David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87 https://t.co/3dMJ3lfOWE via @NYTimes
nytimes.com
He was only 37 when he made a discovery that challenged the existing tenets of biology and led to an understanding of retroviruses and viruses, including H.I.V.
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🚨📢❗So proud and excited to share our latest work, "Clonal Hematopoiesis Dynamics and Evolutionary Fitness During Cancer Treatment Impact Clinical Outcomes", now available: https://t.co/EQu4Ilx2Hf🧵
medrxiv.org
Clonal hematopoiesis (CH) is the age-related expansion of mutated hematopoietic stem cells without other hematologic abnormalities. In patients with solid tumors, CH is associated with higher...
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Congrats to Eric Vick, MD, PhD, Ken Greis, PhD, and Daniel Starczynowski, PhD, on their new Leukemia publication advancing combination strategies for IRAK4-targeted therapy in acute myeloid leukemia. Learn more: https://t.co/CAid18vRXx
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Speaker opportunity at #ASH25! Join this Scientific Workshop: Therapy Resistance Mechanisms in Blood Malignancies w/ organizers @dstarczynowski @glytsou @PanosNtz! View all 10 Scientific Workshops with more speaker opportunities: https://t.co/yRGQ3C9PSr
#Hematology
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Got new insights into therapy resistance mechanisms in heme malignancies? We'd love to hear from you - please reach out to @PanosNtz, @dstarczynowski, or me to share your findings at the @ASH_hematology Scientific Workshop #ASH25
The workshop takes place Friday, Dec 5, 2025, during #ASH25 @ASH_hematology Speaker slots still available! Contact us if you’re interested—especially junior clinicians and basic/translational scientists.
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The workshop takes place Friday, Dec 5, 2025, during #ASH25 @ASH_hematology Speaker slots still available! Contact us if you’re interested—especially junior clinicians and basic/translational scientists.
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We'll cover 4 key areas: • Epigenetic & chromatin mechanisms • Post-transcriptional regulation • Translational/post-translational control • Metabolism & mitochondrial biology
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Integration of phospho-signaling and transcriptomics in single cells reveals distinct Th17 cell fates -> excellent work from @sfortma2, @ChadhaAwal and team! https://t.co/XXXp9onKWc…
@CellReports
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ASH Seeks Fundamental Discovery Science Abstracts for #ASH25 IF the quality is there, the fundamental basic science poster and presentations will E X P A N D at ASH25. Its an experiment! Submit your cool basic science before August 5, 2025, at 11:59 p.m.
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Grateful to the editors and reviewers for the valuable guidance. Special thanks to our fantastic team in the Starczynowski Lab, the Advanced Leukemia Therapies and Research Center, @uofcincycancer, @CincyChildrens, @ChildrensCBDI, and @NIH.
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This study uncovers a novel synthetic lethal strategy in AML by co-targeting IRAK4 and GSPT1, converging on c-Myc destabilization—a key oncogenic driver.
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The top hit? CC-885, a CELMoD that degrades GSPT1: 1. CC-885 preferentially kills IRAK4-deficient/inhibited AML cells. 2. Combination of IRAK4 inhibition + GSPT1 degradation leads to rapid c-Myc protein loss. 3. This synergy is selective for AML and spares normal blood cells.
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