Daniel Starczynowski
@dstarczynowski
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Professor at Cincinnati Children’s Hospital. Cancer biologist focused on hematologic malignancies (#MDS and #AML). Views my own.
Joined December 2012
RT @pvyas_oxford: Detecting and quantifying clonal selection in somatic stem cells | Nature Genetics. So pleased to share this work. It is….
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RT @EricTopol: Clonal hematopoiesis (CH, blood stem cells with mutations) is considered a risk factor for cardiovascular disease and other….
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Congrats Courtnee!!.
Excited to share the first work from my post doc out today in @LeukemiaJnl!.
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Please reach out as the model is widely available. For more information, check out our blog:
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These findings highlight UBA6 as a druggable vulnerability in VEXAS. Targeting this pathway could offer a more precise, less toxic therapy. We’re just scratching the surface—but future studies may open new therapeutic doors for patients with VEXAS & UBA1-mutant MDS.
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Enter phytic acid (IP6) - a natural UBA6 inhibitor found in grains & legumes. In our studies, IP6 killed UBA1-mutant cells, spared normal cells, extended survival in mouse models, and was well tolerated.
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Therapeutically, directly inhibiting UBA1 is toxic to all cells. But inhibiting the other E1 enzyme—UBA6—selectively kills UBA1-mutant cells. A synthetic lethality approach.
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We developed a human cell line model expressing the patient-specific UBA1 mutation. These cells mimicked disease features—protein stress, vacuoles & inflammatory changes—giving us a powerful tool to study VEXAS.
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#VEXAS syndrome is caused by somatic mutations in UBA1, a gene encoding a ubiquitin-activating enzyme. Patients develop late-onset inflammation + hematologic features including vacuoles in marrow cells and cytopenias—often progressing to MDS. But mechanisms are poorly understood.
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Huge congratulations to first author Courtnee Clough, and deep thanks to co-authors and collaborators, including Claire Cunningham, Sophia Philbrook, and others at Cincinnati Children’s and UCCC (@uofcincycancer). Grateful to support from @CincyChildrens @ChildrensCBDI and @NIH.
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Excited to share our latest study published in Leukemia (@LeukemiaJnl): Characterization of E1 enzyme dependencies in mutant-UBA1 human cells reveals UBA6 as a novel therapeutic target in VEXAS syndrome
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A daring proposal to issue $750 billion in bonds for medical cures garners attention - The Cancer Letter
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Congrats Mark!!.
Incredibly humbled & grateful to @ASH_hematology for the honour of the William Dameshek Prize. A recognition that belongs to the awesome scientists I have the privilege of working with every day in @TheDawsonLab @PeterMacRes @GenCancerCentre.
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Congrats Anand!!.
Unbelievably honored to have received a career award from @BWFUND. Hard to express how meaningful this support is in times like today. Also hard to express enough gratitude to my family, to my mentors, and to the patients we do this for.
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Congrats @AAnandappa !!!.
Congrats @AAnandappa on such a well deserved award and amazing achievement! You're an allstar!.
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RT @_TanyaBondar_: GEN-PHEN-VEN: GENetic and PHENotypic features predict VEN therapy outcomes. Like light travelling through a crystal aug….
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Congrats to the entire team…fascinating and very interesting new biology on IDH mutant AML!.
Excited to share with all our latest work on the use of single cell tools in following IDH mutant AML patients during their treatment! Out today @CellStemCell !! An amazing collaboration with @AkEisfeld & @PapaemmanuilLab & @landau_lab !!! Driven by the impressive @MariaSirenko
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Congrats to all the UCCC Pilot Project Awardees! @uofcincycancer @ChildrensCBDI.
Congrats to our Spring 2025 Pilot Project Award recipients! These 10 researchers will receive funding to launch innovative cancer studies that lay the groundwork for larger grants and greater impact. #CancerResearch
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RT @uofcincycancer: Congrats to our Spring 2025 Pilot Project Award recipients! These 10 researchers will receive funding to launch innovat….
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Congrats Linde!!.
Thank you to @uofcincycancer for the support of our work and congrats to all of the awardees!.
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