Chander S Digwal
@digwal_chander
Followers
35
Following
197
Media
0
Statuses
155
Joined August 2021
📸OUT NOW in @JoVEJournal: Mapping Dysfunctional Protein-Protein Interactions in Disease. Our method article is available now with video component coming soon! https://t.co/9AZdrUPx3s
#PPI #networkbiology #cancerbiology #dfPPI #MassSpectrometry #Proteomics
0
9
10
Proteins rarely work alone. Their functions emerge from networks of interactions—dynamic connections that continuously reorganize to maintain cellular balance. What happens when this balance is lost? This blog dives into our @TrendsBiochem review article:
communities.springernature.com
Proteins rarely work alone. Their functions emerge from networks of interactions—dynamic connections that continuously reorganize to maintain cellular balance. But what happens when this balance is...
0
7
9
How can post-translational modifications rewrite cellular networks? Read https://t.co/wGytP54NTl
@SpringerNature @TrendsBiochem
#Epichaperome #PTMs #NetworkBiology #SystemsBiology #MolecularChaperones #CellBiology #Neurodegeneration #CancerResearch
0
10
11
@chiosislabmskcc @TrendsBiochem Dive deeper into the concept behind our @TrendsBiochem TIBS cover article! Read more on @SpringerNature Communities https://t.co/Aa8KLvUlx1
#Epichaperome #PTMs #NetworkBiology #SystemsBiology #TrendsBiochem #NatureCommunities
communities.springernature.com
0
8
7
🚨Publication alert! The final version of our article is OUT NOW in @TrendsBiochem. @ChiosisLabmskcc is honored to have been selected as the cover feature for this issue - cover art by a VI4 Artist in Residence. Check out the review article here: https://t.co/Yf9GzchU8P
⭐️Very excited to share that our article 'PTMs as Molecular Encoders: Reprogramming Chaperones into Epichaperomes for Network Control in Disease' is out online now in @TrendsBiochem
#PTMs #HSP90 #epichaperome #PPI #neuroscience
https://t.co/pszZWjRGLb
1
10
9
🍂Happy Autumn! It was a busy summer in @ChiosisLabMSKCC! We had 10 high school & undergraduate students join us for mentorship. We are so grateful for the opportunity to part of their research journeys & looking forward to hearing about all of their future achievements!😃🥼
0
5
5
Now accepting applications for our 2026 #Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose, & treat cancer. https://t.co/sVebvs82cO
1
3
9
🌞🥼Summer intern shoutout! Ishaan presented his work from the last few months under the mentorship of Dr. Sahil Sharma @SsGq2009 at the student symposium last week . Congratulations Ishaan!🥳 We cannot wait to see what your future holds 🤓
1
4
9
Online now - PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease
cell.com
Recent discoveries reveal that post-translational modifications (PTMs) do more than regulate protein activity – they encode conformational states that transform chaperones into epichaperomes:...
0
9
10
Fantastic review by @GabrielaChiosis and team connecting the epichaorome with the chaperone code
⭐️Very excited to share that our article 'PTMs as Molecular Encoders: Reprogramming Chaperones into Epichaperomes for Network Control in Disease' is out online now in @TrendsBiochem
#PTMs #HSP90 #epichaperome #PPI #neuroscience
https://t.co/pszZWjRGLb
0
9
19
⭐️Very excited to share that our article 'PTMs as Molecular Encoders: Reprogramming Chaperones into Epichaperomes for Network Control in Disease' is out online now in @TrendsBiochem
#PTMs #HSP90 #epichaperome #PPI #neuroscience
https://t.co/pszZWjRGLb
0
11
24
In memory of Len Neckers, whose pioneering work on #HSP90 and #PTMs laid the foundation for how we think about chaperone regulation. Our latest @TrendsBiochem review builds on this legacy to explore the formation and function of #epichaperomes. https://t.co/m0ZwHqoGDy
0
12
20
Don't miss him in the MEDI: General Poster Session Tuesday, August 19, 2025, 6:00 PM – 8:00 PM Hall C – Walter E. Washington Convention Center Poster Board #: 577! #ACSFall2025 #posterpresentation #GRP94 #epichaperomics #glycosylation #drugdevelopment #medicinalchemistry
0
4
2
Are you attending #ACSFall2025? Keep an eye out for @digwal_chander, he will be presenting Targeting Aberrantly Glycosylated GRP94: Conformational Dynamics and Implications for Drug Design early next week! #GRP94 #epichaperomics #glycosylation #proteinproteininteraction #PPI
1
3
4
Accepted manuscript alert! Our review "#Epichaperomes: Redefining #ChaperoneBiology and Therapeutic Strategies in Complex Diseases" is now out in @RSC_ChemBiol #DrugDiscovery #NetworkMedicine #SystemsBiology #PrecisionTherapeutics
pubs.rsc.org
The complexity of disease biology extends beyond mutations or overexpression, encompassing stress-induced mechanisms that reshape proteins into pathological assemblies. Epichaperomes, stable and...
0
4
5
Sahil presented earlier this month at #AAIC2025 in Toronto @alzassociation. This work was supported by @_BrightFocus & @NIHAging and aims to advance #precisionmedicine in #neurodegeneration through the development of small molecule probes for #epichaperome imaging in #Alzheimers.
0
6
10
Have you checked out our latest @NatureComms article? Learn about how #phosphorylation can impact the conformation of the ubiquitous protein #HSP90 thus opening therapeutic avenues & drugging the undruggable #epichaperome #CancerResearch #PrecisionMedicine
nature.com
Nature Communications - Epichaperomes are chaperone assemblies that reorganize protein networks under stress. Here, authors reveal how HSP90 phosphorylation drives epichaperome formation, linking...
0
7
13
🚨 Our review "#Epichaperomes: Redefining #ChaperoneBiology and Therapeutic Strategies in Complex Diseases" is now out in @RSC_ChemBiol as an Accepted Manuscript! #DrugDiscovery #NetworkMedicine #SystemsBiology #PrecisionTherapeutics
https://t.co/Hw87rM5gH4
0
8
12
Epichaperomes: Redefining Chaperone Biology and Therapeutic Strategies in Complex Diseases - now published in RSC Chemical Biology
pubs.rsc.org
The complexity of disease biology extends beyond mutations or overexpression, encompassing stress-induced mechanisms that reshape proteins into pathological assemblies. Epichaperomes, stable and...
0
2
4