Dennis Kappei
@denniskappei
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Assistant Professor @NUSMedicine & PI @csi_singapore | EMBO Global Investigator | Our research group works on telomeres, chromatin & proteomics 👨🔬🧪🧬
Singapore
Joined December 2015
Interested in Pursuing a PhD in Cancer Biology? Join us for an exclusive CSI Graduate Program Virtual Sharing Session! #CancerResearch #CancerBiology #CancerScience #PhDLife #PhDOpportunity #BiomedicalResearch #MolecularBiology #CellBiology #TranslationalResearch
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That’s a wrap on the Diana Koh Breakthroughs in Cancer Learning Series 2025! 🧬✨ Insightful talks by Prof. Goh Boon Cher & Dr. @denniskappei made cancer science accessible to all. Congrats to our Young Innovator Prize & Grant winners!
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So wonderful to see our recent work on the cover of @embojournal, beautifully illustrated by @DrawImpacts - not only visualising our scientific discovery but also celebrating our beautiful environment in #Singapore. 🤩 https://t.co/59Hro8WIPc
embopress.org
imageimageExpression of CIITA, the master regulator of MHC-II expression, is governed by three cell type-specific promoters. This study identifies ZBTB48 as a priming factor for CIITA promoter III...
Our final 2024 issue! Highlight: New players in lysosomal sorting via mannose-6-phosphate mRNA deadenylation & decay relations Plant ALBA proteins facilitate m6A reading and lots more! Cover: Grishma Rane @GrishTweets, Dennis Kappei @denniskappei et al https://t.co/DKsxYZQ852
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ZBTB48 is a priming factor regulating B-cell-specific CIITA expression @denniskappei and coworkers @NUSMedicine @csi_singapore
https://t.co/hLLik28KJF
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Now out in @embojournal, @GrishTweets's work describing ZBTB48 as a priming factor regulating B-cell-specific CIITA expression (our original preprint and details below). 🎉 https://t.co/59Hro8WIPc
@csi_singapore @N2CR_Singapore @NUSMedicine
embopress.org
imageimageExpression of CIITA, the master regulator of MHC-II expression, is governed by three cell type-specific promoters. This study identifies ZBTB48 as a priming factor for CIITA promoter III...
We are excited to share our latest @biorxivpreprint led by @GrishTweets in our team @csi_singapore/ @NUSMedicine/@N2CR_Singapore discovering ZBTB48 as a pioneer factor for B-cell-specific CIITA expression upstream of the MHC II adaptive immunity program.
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Interested in Pursuing a PhD in Cancer Biology? Join us for the CSI Graduate Program Virtual Sharing Session! Discover exciting opportunities offered & the scholarship available for successful applicants. Hear directly from current scholars as they share their experiences.
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The CSI Graduate Program offers PhD students premium scholarship, education allowances, hands-on training, and mentorship to become leaders in cancer research. With comprehensive support, you'll advance your career in cancer research. https://t.co/C4Aplix1Ih
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Glad our paper is finally out, highlighting a role for PRMT5 in replication stress-mediated transcriptional induction of ISGs and ERVs. A fun collaboration with my good friend and former colleague @adj_23. Kudos to Phuong, @denistorrre @denniskappei
science.org
PRMT5 promotes immune activation during replication stress.
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It's the last day of the EMBO Chromatin Biology in Cancer Workshop 2024! We thank all our speakers, organisers, delegates and editors who were in attendance at this workshop 😊
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The EMBO Global Investigator Network supports group leaders setting up their laboratories in #Chile #India #Singapore or #Taiwan. Apply by 1 June. #excellence in #lifesciences #funding
https://t.co/9aZwpztwP9
embo.org
Supporting young group leaders in Chile, India, Singapore and Taiwan
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Inviting outstanding researchers in the field of epigenetics/chromatin biology with a focus on cancer to the EMBO Chromatin Biology in Cancer Workshop 2024! Abstract Submission & Registration EXTENDED till 14 Feb 2024: https://t.co/kmQyOMbjNK
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Only 10 days left to register and submit your abstracts for the @EMBO workshop Telomere function in health and disease 2024. Don't miss the opportunity to participate in this fantastic meeting! Looking forward to see you in #Rome! https://t.co/3QXoiuM2RB
meetings.embo.org
Telomeres are specialized structures that protect the ends of linear chromosomes in eukaryotes. Research in this area has revealed that telomere maintenance is critical for stem cell function and nor…
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Please join us for this @EMBO workshop on chromatin biology in cancer with so many amazing speakers including several @EMBO_YIP and great networking opportunities in beautiful #Singapore. There will be plenty of talks selected from abstracts - register and submit until 1 Feb!
Inviting outstanding researchers in the field of epigenetics/chromatin biology with a focus on cancer to the EMBO Chromatin Biology in Cancer Workshop 2024! Abstract Submission & Registration OPEN till 1 Feb 2024: https://t.co/kmQyOMbjNK
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Especially as a European who has found a home away from home, I am thrilled to become a part of this impressive network. This really is a reflection of the amazing people in our research group and the nurturing support from @csi_singapore & @NUSMedicine. 💙🥳🎉
Ten life scientists are welcomed to the EMBO Global Investigator Network, which provides access to the EMBO networking and training activities https://t.co/pkfgnWxReU
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The lab is finishing the year strong with our paper describing ZNF524 as a direct telomere-binder now out @NatureComms. Congratulations to @HannaBraun519 and the entire team @csi_singapore, @N2CR_Singapore, @NUSMedicine, @imbmainz & @USTCGlobal! 🧬🎉🥳 https://t.co/l3dNvomFCq
We are excited to share @HannaBraun519's discovery of ZNF524 as a direct telomere-binder - online @biorxivpreprint. This is a close collaboration between the Butter lab @imbmainz, the Li lab @USTCGlobal and our group at @csi_singapore and @N2CR_Singapore.
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Congratulations to the 4 ladies for their excellent abstracts & poster presentations! The Top 2 have won themselves the AACR Travel Award to facilitate their attendance at AACR 2024. @NTU_LKCMedicine @AACR @dukenus @astar_gis @NUSMedicine
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We are very excited that our work on TERT promoter mutations is now out @genomeresearch. While scientific publishing is often challenging, here we are really grateful for a great experience with efficient editors and constructive reviewers! 🧬🥳🎉 https://t.co/0gBYYLEbYt
Our lab has been ringing in the new year with some fresh manuscripts on @biorxivpreprint. Boon Haow in our lab @csi_singapore has been studying transcription factors to regulate the (telomerase) TERT promoter in a mutation-specific manner.
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Super excited to be co-organising this @EMBO Workshop on "Chromatin Biology in Cancer" with @VallotCeline, @Pollych34650771, Giovanni Tonon & Pierre-Antoine Defossez. Please join us and an amazing line-up of speakers in April 2024 in Singapore!
The EMBO Workshop on Chromatin Biology will be happening on 23rd to 26th April 2024 at National University of Singapore. Register here: https://t.co/mrLncghIto
#EMBO2024 #cancerresearch #chromatinbiology
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This work started as a "side project" with two incredible interns, @Julia_Hansen13 and Ieva Norvaisaite, and then was grown into the above by @GrishTweets with help from a set of fantastic colleagues @csi_singapore, @NUSMedicine, @N2CR_Singapore and collaborators @USTCGlobal.
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Are there maybe other TFs that are on-off-switches for a handful of target genes each? Given the 4-digit number of human TFs and as illustrated by @matthewhirschey many human genes are poorly studied, one might wonder about an "expression circuit"... https://t.co/omenfPFtGl
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