Delgoffe Lab
@DelgoffeLab
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Cancer Immunometabolism - Professor - Director: Tumor Microenvironment Center - @PittTweet @UPMCHillmanCC - CoFounder:Novasenta - EiC:Immunology - views my own
Pittsburgh, PA
Joined June 2017
Thrilling first day at the @KeystoneSymp Immunometabolism conference. The future is bright! Thinking deeply about spatial metabolite distribution, acute vs chronic effects of diet, and incorporating new cell types/states into the immunometabolic lexicon.
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Drew in my lab created an immunology themed-board game! Pathogens and immune cells act against one another. And, in appropriate fashion, the currency is *drumroll* metabolites! Read a great write up from our department on this game and Drew’s research!
At @pitt_immunology, we don't just work hard—we play hard, too. Just ask postdoc Drew Wilfahrt, of the @DelgoffeLab, who created a board game about the immune system! Read about Immune Horizon and the research that inspired the game: https://t.co/tf0IJbQLPx
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I think this shot summarizes why @pitt_immunology @PittTweet @UPMCHillmanCC is such a great place to do cancer immunology. Mike Lotze (“Mr. IL-2”) introducing Olja Finn (cancer vaccine pioneer) to a packed house for our Pinnacles of Science seminar, celebrating an amazing career!
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Yes, I’ve seen long lists of China drug assets that are being shopped around prior to JPM. TL1A/IL23 bispecifics, CD19/BAFF TCEs, PD-1/VEGF, IL17A/F antibodies... It may come one day but the future of breakthrough medicines is not there yet. I’ll bet on US academic and biotech
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I was curious about the most cited (non-Covid) clinical trial from the last 10 years — it's this one: 11,288 citations Pembrolizumab beat chemotherapy in PDL1–positive non–small-cell lung cancer, dislodged it as the first-line treatment (and ended up doubling median survival)
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As 2025 is drawing to a close, @JExpMed would like to highlight all of the women who have contributed to the #WomenInSTEM #Viewpoint series over the last 3 years! Learn more about their scientific journeys on the path to independence here 👉 https://t.co/WZeOWtF5dQ
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Congratulations to our faculty @OveracreLab and Aravind Cherukuri for being selected to present their research for the @PittHealthSci 2026 Senior Vice Chancellor’s Research Seminar Series! https://t.co/Ph7LOH9qB9
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The Immunology Department has really upped it's communication game as of late. This newsletter does a great job of conveying our incredible community at Pitt. Plenty of @Pitt_PMI students featured here, as well as great science!
Introducing the Pitt Department of Immunology's new quarterly newsletter, ImmunoSurveillance! We're excited to share the incredible research happening in the department and our amazing immunology community that makes it all possible. https://t.co/WQ2eRRDcW1
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I couldn’t agree more!
From @DrSidMukherjee Metabolism is the next frontier in cancer treatment https://t.co/4RNodkeZiO “Now we must listen to the hungers and handicaps of malignant cells, and use them”
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New in @ImmunityCP: @Vignali_Lab and colleagues tell the #Treg story, tracing the history of these critical immune regulator cells and their path to earning the 2025 #NobelPrize. https://t.co/FndBdbozi0
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Last Friday we held our annual @Pitt_PMI retreat! Honored to Direct this graduate program led by such incredible trainee scientists!
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#News: KaliVir has entered a clinical trial collaboration with @Roche to evaluate VET3-TGI + atezolizumab (Tecentriq ®). Built on our VET™ platform, VET3-TGI drives selective tumor cell breakdown and immune activation. Read more: https://t.co/GKK7QP1yID
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Congrats to our 6 members who have been named to @Clarivate's #HighlyCited2025! ⭐️John Byrd ⭐️Greg Delgoffe @DelgoffeLab ⭐️Valerian Kagan ⭐️John Kirkwood @jmkirkwood ⭐️Dario Vignali @Vignali_Lab ⭐️Simon Watkins @simoncwatkins1
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On the latest Outperform Cancer podcast, @OveracreLab chats with @marybethgilliam about her new research showing that the artificial sweetener #sucralose weakens #immunotherapy effectiveness by disrupting the #microbiome
https://t.co/DJXHxd0BGM
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Congratulations to Dario Vignali, Greg Delgoffe, Sally Wenzel and Simon Watkins for making the #Clarivate #HighlyCited2025 list, recognizing their broad and significant influence in their fields!
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This has gone too far! Too far!
"Italy’s biggest pasta exporters say import and antidumping duties totaling 107% on their pasta brands will make doing business in America too costly and are preparing to pull out of U.S. stores as soon as January."
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Hot take: in 2018-2020 immuno-oncology was bubble-level big. Companies and highly clinical talks diluted out SITC's science. The future of cancer immunotherapy is bright, but the next wave of IO will originate (again) from discovery science and dedicated industry partners. 5/5
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Bispecifics are cool, yes; but PD-(L)1 x VEGF will not save IO. We need new targets, new approaches, and (frankly) new biology and understanding to move the needle beyond PD-1. 4/
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