https://t.co/Z9RWhgreFy

@lemire I think we should have a new runtime option where stack, heap, bss, and tls are all in zones where it is guaranteed that any load of any legally addressable byte is guaranteed not to be <64 bytes from a page boundary or anything that will cause a disaster if loaded. ...

Contemplating a type system where the bit sizes required are 1, 2, 4, 8, 9, 16, 17, 32, 33, 64, 65, 128, 256, 512. Disgusting stuff, I should be ashamed of myself.

Having to pattern match Optional::None and Optional::Some(Optional::None) separately is exactly like that joke about Sartre ordering a coffee with no cream, only to be told “I���m sorry monsieur, we don’t have any cream, would you like it with no milk instead?”

@sumedha2199 It takes some mental rigour to clarify thoughts via text. Too many people are weak in thinking so they’d rather have you on a call where they can ramble off and force you to interpret their gibberish. Also, most calls are not recorded, so if you mess up, the blame is on you

I abhor that computer programmers still use the term “word”. > Size=2 means a word (2 bytes) Just say it’s 2-bytes. Word and Dword and Qword are stupid terms that should never be used by anyone in 2025. Just say how many bytes and be done with it!

I made https://t.co/0Iv89N1bku I did this because the r/bioinformatics channel doesn't like talking about tools, especially if you wrote it yourself. If you build bioinformatic tools or want to learn more about it, join the subreddit and start posting :)

Barbell is out now: a new demultiplexer with much higher accuracy than eg Dorado. See the bsky threads for more: https://t.co/UlBy6U80Ei

And still probably 95% of programmers are like "don't worry about the low level details, the compiler will take care of it"

How can you gain a 40x increase in throughput over the #Rustlang standard library implementation? In 15 minutes, @curious_coding will show how to exploit what modern CPUs offer so you can achieve faster binary search. Join here > https://t.co/8jEbY0b0RC #ScyllaDB #P99CONF

@ChShersh i want knowledge to be passed by reference not by value

After years of research and continuous refinement, we’re thrilled to share that our paper on the MetaGraph framework — enabling Petabase-scale search across sequencing data — has been published today in Nature ( https://t.co/WQgDjIYDZL).

How can you achieve 40x faster binary search? @curious_coding's #P99CONF talk will dive into everything that modern CPUs have to offer in order to gain 40x increased throughput over the Rust standard library implementation. Save your spot here > https://t.co/uCyw7JIIXu #ScyllaDB

I'm having a talk on "40x faster binary search" at #p99conf next Wednesday, Oct 22! Register now :) https://t.co/OmrE1iNcfK

It’s a bit easier to just explain how we got here. In the old days, memory and CPU ran at the same speed. The laws of physics make it incredibly hard to ramp up the MHz of the CPU while keeping physically separated memory chips in sync. The distance is just too far for the

Asymptotically, O(n^(1/3)) isn't quite achievable in this universe for a variety of reasons, and you have to be pretty clever to even get O(n^(1/2)). If you fill space with memory cells that don't collapse into a black hole then memory access actually takes O(n) time!

Memory access is O(N^[1/3]) https://t.co/4VRZLFhUwm

I am calling for a moratorium on new tote bags. We all have more than enough tote bags already. Stop giving me tote bags at conferences. I do not want or need any more tote bags. See also: water bottles

So tired of this.

No longer interested in a H1-B visa? You can work for @PacBio as a Bioinformatics Software Engineer even from Europe. Apply today!

It seems a common experience in the lives of people with high agency is that they, at some point, metaphorically, lean against a wall and discover that there is a hidden door.