Woop! Woop! A neat new preprint with @AKShcherbakova and Daniel Buchan, using variational autoencoders to generate minimal E. coli genomes:.@ucl @uclcdb @uclcs.

RT @ProfTomEllis: Online now @ Cell is the yeast multicellular engineering paper from @DrFankangMeng - the fruits of his productive PhD. H….

RT @GaryMirams: We're hosting a symposium "Asymptotics, PDEs, Industrial Mathematics and Systems Biology" to celebrate John King's Fellows….

RT @MarcoMauri81: 🚨 Next Friday 13/06 at 15:30 EU time, Katja Taute (Uni Leipzig) will present the talk . Bacterial navigation in complex e….

RT @pdhsu: What if we could universally recombine, insert, delete, or invert any two pieces of DNA?. In back-to-back @Nature papers, we rep….

RT @lubingxin: Just one week left to apply for this postdoc position! A great opportunity to contribute to impactful research on cancer evo….

RT @Leftfield: We’re playing the @Fac51hacienda open-air show @Walton_Gardens, Cheshire w/ our friends, the awesome @orbital . What a DJ li….

RT @DrLeoRios: I’m currently looking for a short-term candidate for a #Research #Associate #Postdoc position in my group @LeoRiosLab @UCLBi….

RT @UCL_IPLS: 📢Registration is open for our IPLS Annual Symposium, 11th June 2025!.We will showcase exciting #interdisciplinary #research p….

Our model provides quantitative insights into the relationships among breakage-fusion-bridge cycles, chromothripsis, seismic amplification, and extrachromosomal circular DNA. We also used the model for Bayesian inference in whole-genome sequencing data to infer key parameters.

Despite numerous studies on detecting various SV patterns, general quantitative models of SV generation have been lacking.​ In this study, we developed a computational cell-cycle model including double-strand break formation, followed by end-joining repair and replication.

Chromosomal instability (CIN) is a hallmark of many human tumours, often leading to structural or numerical chromosomal aberrations. While somatic structural variants (SVs) and copy number alterations are intimately related, they are frequently studied independently.

I'm excited to share our latest research published in Nature Communications: "Cell-cycle dependent DNA repair and replication unifies patterns of chromosome instability." . @lubingxin @wchcross.

RT @lubingxin: Are you interested in cancer genomics and cancer evolution? A 3-year postdoc position available.to join my MRC-funded projec….

RT @BobbyBentham: 🚀 Our paper introducing ImmuneLENS, a new tool that measures T and B cell fractions from WGS data. This builds on our pre….

RT @BrianHie: Paper: Blog:

RT @VShahrezaei: I have a postdoc position in my group @imperialcollege @ImperialMaths through a joint @LeverhulmeTrust grant with @swainqb….

RT @BiologyAIDaily: Generator: A Long-Context Generative Genomic Foundation Model. 1/ The "Generator" is introduced as a long-context gener….

Come and join our lab on a funded undergrad summer project courtesy of @UCL_IPLS !.

RT @BrandesNadav: New preprint claims that most existing DNA language models perform just as well with random weights, suggesting that pret….

RT @AngelGMoreno: Massive upgrade to our preprint "Reprogramming genetic circuits using space": mathematical modeling, time-based experimen….